α-1-adrenergic receptor agonist activity of clinical α-adrenergic receptor agonists interferes with α-2-mediated analgesia

Anesthesiology

Volumn 110, Issue 2, 2009, Pages 401-407

  Gil, Daniel W ^a   Cheevers, Cynthia V ^a   Kedzie, Karen M ^a   Manlapaz, Cynthia A ^a   Rao, Sandhya ^a   Tang, Elaine ^a   Donello, John E ^a  

^a ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLURAPIDIL; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BRIMONIDINE; CLONIDINE; N METHYL DEXTRO ASPARTIC ACID; PRAZOSIN; SULPROSTONE; TIZANIDINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; CALCIUM; DRUG DERIVATIVE; N METHYLASPARTIC ACID; PROSTAGLANDIN E2; QUINOXALINE DERIVATIVE;

ALLODYNIA; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; FLUOROMETRY; HYPERSENSITIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEDATION; STIMULUS RESPONSE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG INTERACTION; DRUG POTENTIATION; EXPLORATORY BEHAVIOR; GENETICS; HYPERALGESIA; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; MOUSE MUTANT; PAIN ASSESSMENT; PHYSIOLOGY;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS; ANIMALS; CALCIUM; CLONIDINE; DINOPROSTONE; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; EXPLORATORY BEHAVIOR; HYPERALGESIA; INJECTIONS, SPINAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-METHYLASPARTATE; PAIN MEASUREMENT; PRAZOSIN; QUINOXALINES; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 61549128656     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181943226     Document Type: Article

References (25)

1. Eisenach JC, DuPen S, Dubois M, Miguel R, Allin D: Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. Pain 1995; 61:391-9
2. Eisenach JC, Rauck RL, Buzzanell C, Lysak SZ: Epidural clonidine analgesia for intractable cancer pain: phase I. ANESTHESIOLOGY 1989; 71:647-52
3. Eisenach JC, Lysak SZ, Viscomi CM: Epidural clonidine analgesia following surgery: phase I. ANESTHESIOLOGY 1989; 71:640-6
4. Filos KS, Goudas LC, Patroni O, Polyzou V: Intrathecal clonidine as a sole analgesic for pain relief after cesarean section. ANESTHESIOLOGY 1992; 77:267-74
5. Davis KD, Treede RD, Raja SN, Meyer RA, Campbell JN: Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain. Pain 1991; 47:309-17
6. Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR Jr, Trendelenburg U: International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 1994; 46:121-36
7. Hunter JC, Fontana DJ, Hedley LR, Jasper JR, Lewis R, Link RE, Secchi R, Sutton J, Eglen RM: Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997; 122:1339-44
8. Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL: The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 1997; 17: 7157-65
9. Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE: Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci USA 1997; 94:9950-5
10. Fairbanks CA, Stone LS, Kitto KF, Nguyen HO, Posthumus IJ, Wilcox GL: alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol Exp Ther 2002; 300:282-90
11. Hylden JL, Wilcox GL: Intrathecal morphine in mice: a new technique. Eur J Pharmacol 1980; 67:313-6
12. Gil DW, Cheevers CV, Donello JE: Transient allodynia pain models in mice for early assessment of analgesic activity. Br J Pharmacol 2008; 153:769-74
13. Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR: Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature 1993; 363:274-6
14. Kingery WS, Guo TZ, Davies MF, Limbird L, Maze M: The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain 2000; 85:345-58
15. Sato J, Perl ER: Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 1991; 251:1608-10
16. Birder LA, Perl ER: Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation. J Physiol 1999; 515(Pt 2):533-42
17. Schwinn DA, Johnston GI, Page SO, Mosley MJ, Wilson KH, Worman NP, Campbell S, Fidock MD, Furness LM, Parry-Smith DJ: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther 1995; 272:134-42
18. Bylund DB, Blaxall HS, Iversen LJ, Caron MG, Lefkowitz RJ, Lomasney JW: Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol Pharmacol 1992; 42:1-5
19. Millan MJ: Descending control of pain. Prog Neurobiol 2002; 66:355-474
20. Ozdogan UK, Lahdesmaki J, Hakala K, Scheinin M: The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol 2004; 497:161-71
21. Hein L, Kobilka BK: Adrenergic receptor signal transduction and regulation. Neuropharmacology 1995; 34:357-66
22. Hieble JP, Bylund DB, Clarke DE, Eikenburg DC, Langer SZ, Lefkowitz RJ, Minneman KP, Ruffolo RR Jr: International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev 1995;47:267-70
23. Reader TA, Briere R, Grondin L: Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: competition studies with [3H]prazosin and [3H]idazoxan. J Neural Transm 1987; 68:79-95
24. Starke K: Alpha-adrenoceptor subclassification. Rev Physiol Biochem Pharmacol 1981; 88:199-236
25. Virtanen R, Savola JM, Saano V, Nyman L: Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol 1988; 150:9-14