Functional characterization of nonadrenergic noncholinergic neurotransmitter release via endocannabinoids: An in vitro study in rabbit corpus cavernosum

Journal of Sexual Medicine

Volumn 6, Issue 3, 2009, Pages 717-729

  Vural, Ismail M ^a   Ozturk, Gokce S ^a   Sarioglu, Yusuf ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Corpus cavernosum; Endocannabinoids; Nitric oxide; Nonadrenergic noncholinergic Neurotransmission; Rabbit

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ANANDAMIDE; ATROPINE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CAPSAZEPINE; ENDOCANNABINOID; GUANETHIDINE; N(G) NITROARGININE METHYL ESTER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; ELECTROSTIMULATION; MALE; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE RELAXATION;

EID: 61549106635     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.01003.x     Document Type: Article

References (48)

1. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 1995;75:191-236.
2. Saenz de Tejada I. Molecular mechanisms for the regulation of penile smooth muscle contractility. Int J Impot Res 2002;14:S6-10.
3. Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990;170:843-50.
4. Cellek S, Moncada S. Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit. Br J Pharmacol 1998;125:1627-9.
5. Li CG, Rand MJ. Evidence for a role of nitric oxide in the neurotransmitter system mediating relaxation of the rat anococcygeus muscle. Clin Exp Pharmacol Physiol 1989;16:933-8.
6. Ziessen T, Moncada S, Cellek S. Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall. Br J Pharmacol 2002;135:546-54.
7. Ziessen T, Cellek S. Purines and pyrimidines are not involved in NANC relaxant responses in the rabbit vaginal wall. Br J Pharmacol 2002;137:513-21.
8. Werkstrom V, Persson K, Ny L, Bridgewater M, Brading AF, Andersson KE. Factors involved in the relaxation of female pig urethra evoked by electrical field stimulation. Br J Pharmacol 1995;116:1599-604.
9. Simonsen U, Prieto D, Saenz de Tejada I, Garcia-Sacristan A. Involvement of nitric oxide in the non-adrenergic non-cholinergic neurotransmission of horse deep penile arteries: Role of charybdotoxin-sensitive K(+)-channels. Br J Pharmacol 1995;116:2582-90.
10. Kim YC, Davies MG, Hagen PO, Carson CC 3rd. Experimental evidence for endothelium dependent relaxation and neuronal nitric oxide in corpus cavernosum. Yonsei Med J 1994;35:308-13.
11. Okamura T, Ayajiki K, Toda N. Monkey corpus cavernosum relaxation mediated by NO and other relaxing factor derived from nerves. Am J Physiol 1998;274:H1075-81.
12. Yildirim MK, Yildirim S, Utkan T, Sarioglu Y, Yalman Y. Effects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit. Br J Urol 1997;79:964-70.
13. Yildirim S, Ayan S, Sarioglu Y, Gultekin Y, Butuner C. The effects of long-term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes. BJU Int 1999;83:679-85.
14. Bozkurt NB, Vural IM, Sarioglu Y, Pekiner C. Nicotine potentiates the nitrergic relaxation responses of rabbit corpus cavernosum tissue via nicotinic acetylcholine receptors. Eur J Pharmacol 2007;558:172-8.
15. Degroot A, Nomikos GG. In vivo neurochemical effects induced by changes in endocannabinoid neurotransmission. Curr Opin Pharmacol 2007;7:62-8.
16. Harkany T, Guzman M, Galve-Roperh I, Berghuis P, Devi LA, Mackie K. The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol Sci 2007;28:83-92.
17. Barun S, Vural IM, Dilekoz E, Ercan ZS, Sarioglu Y. Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips. Clin Exp Pharmacol Physiol 2005;32:702-7.
18. Schlicker E, Kathmann M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci 2001;22:565-72.
19. da Silva GE, Fernandes MS, Takahashi RN. Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats. Neurosci Lett 2003;349:49-52.
20. Melis MR, Succu S, Mascia MS, Argiolas A. Antagonism of cannabinoid CB1 receptors in the paraventricular nucleus of male rats induces penile erection. Neurosci Lett 2004;359:17-20.
21. Ghasemi M, Sadeghipour H, Mani AR, Tavakoli S, Hajrasouliha AR, Ebrahimi F, Dehpour AR. Effect of anandamide on nonadrenergic noncholinergic-mediated relaxation of rat corpus cavernosum. Eur J Pharmacol 2006;544:138-45.
22. Okamura T, Ayajiki K, Fujioka H, Toda M, Fujimiya M, Toda N. Effects of endothelial impairment by saponin on the responses to vasodilators and nitrergic nerve stimulation in isolated canine corpus cavernosum. Br J Pharmacol 1999;127:802-8.
23. Samata K, Kimura T, Satoh S, Watanabe H. Chemical removal of the endothelium by saponin in the isolated dog femoral artery. Eur J Pharmacol 1986;128:85-91.
24. Srilatha B, Adaikan PG, Li L, Moore PK. Hydrogen sulphide: A novel endogenous gasotransmitter facilitates erectile function. J Sex Med 2007;4:1304-11.
25. Kaya T, Sarioglu Y, Goksu OC, Yildirim S, Yildirim K. Effect of additional testosterone on purinergic responses in isolated rabbit corpus cavernosum strips. Pharmacol Res 1998;37:227-32.
26. Kilicarslan H, Yildirim S, Bagcivan I, Ayan S, Sarac B, Sarioglu Y. Effect of chronic renal failure on the purinergic responses of corpus cavernosal smooth muscle in rabbits. BJU Int 2002;90:596-600.
27. Griffin G, Fernando SR, Ross RA, McKay NG, Ashford ML, Shire D, Huffman JW, Yu S, Lainton JA, Pertwee RG. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. Eur J Pharmacol 1997;339:53-61.
28. Yoshihara S, Morimoto H, Yamada Y, Abe T, Arisaka O. Cannabinoid receptor agonists inhibit sensory nerve activation in guinea pig airways. Am J Respir Crit Care Med 2004;170:941-6.
29. Izzo AA, Mascolo N, Borelli F, Capasso F. Excitatory transmission on the circular muscle of the guinea-pig ileum: Evidence for the involvement of cannabinoid CB1 receptors. Br J Pharmacol 1998;124:1363-8.
30. Pertwee RG, Fernando SR. Evidence for the presence of CB1 receptors in mouse urinary bladder. Br J Pharmacol 1996;118:2053-8.
31. Cristopoulos A, Coles P, Lay L, Lew MJ, Angus JA. Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens. Br J Pharmacol 2001;132:1281-91.
32. Storr M, Gaffal E, Saur D, Schusdziarra V, Allescher HD. Effect of cannabinoids on neuronal transmission in rat gastric fundus. Can J Physiol Pharmacol 2002;80:67-76.
33. Zygmunt PM, Högestätt ED, Waldeck K, Edwards G, Kirkup AJ, Weston AH. Studies on the effects of anandamide in rat hepatic artery. Br J Pharmacol 1997;122:1679-86.
34. Mukhopadhyay S, Chapnick BM, Howlett A. Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and dependent. Am J Physiol Heart Circ Physiol 2002;282:H2046-54.
35. Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgård M, Di Marzo V, Julius D, Högestätt ED. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 1999; 400: 452-7.
36. Ralevic V, Kendall DA, Randall MD, Zygmunt PM, Movahed P, Högestätt ED. Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methananandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries. Br J Pharmacol 2000;130:1483-8.
37. Yan JY, Sun RQ, Hughes MG, McAdoo DJ, Willis WD. Intradermal injection of capsaicin induces acute substance P release from ratspinal cord dorsal horn. Neurosci Lett 2006;410:183-6.
38. Dalsgaard CJ, Vincent SR, Schultzberg M, Hokfelt T, Elfvin LG, Terenius L, Dockray GJ. Capsaicin-induced depletion of substance P-like immunoreactivity in guinea pig sympathetic ganglia. J Auton Nerv Syst 1983;9:595-606.
39. Mc Collum L, Howlett AC, Mukhopadhyay S. Anandamide-mediated CB1/CB2 receptor-independent NO production in rabbit aortic endothelial cells. J Pharmacol Exp Ther 2007;321:930-7.
40. Deutsch DG, Goligorsky MS, Schmid PC, Krebsbach RJ, Schmid HH, Das SK, Dey SK, Arreaza G, Thorup C, Stefano G, Moore LC. Production and physiological actions of anandamide in the vasculature of the rat kidney. J Clin Invest 1997;100:1538-46.
41. Pu XY, Wang XH, Gao WC, Yang ZH, Li SL, Wang HP, Wu YL. Insulin-like growth factor-1 restores erectile function in aged rats: Modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monophosphate signaling activity. J Sex Med 2008;5:1345-54.
42. Tokanovic S, Malone DT, Ventura S. Stimulation of epithelial CB 1 receptors inhibits contractions of the rat prostate gland. Br J Pharmacol 2007;150:227-34.
43. Randall MD, Alexander SP, Bennett T, Boyd EA, Fry JR, Gardiner SM, Kemp PA, Mc Culloch AI, Kendall DA. An endogenous cannabinoid as an endothelium-derived vasorelaxant. Biochem Biophys Res Commun 1996;229:114-20.
44. Kun A, Kiraly I, Pataricza J, Marton Z, Krassoi I, Varro A, Simonsen U, Papp JG, Pajor L. C-type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries. J Sex Med 2008;5:1114-25.
45. Chu LL, Adaikan PG. Role of chloride channels in the regulation of corpus cavernosum tone: A potential therapeutic target for erectile dysfunction. J Sex Med 2008;5:813-21.
46. Moezi L, Gaskari SA, Liu H, Baik S, Dehpour AR, Lee SS. Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB1 and VR1 receptors. Br J Pharmacol 2006;149:898-908.
47. Onaivi ES, Ishiguro H, Sejal P, Meozzi PA, Myers L, Tagliaferro P, Hope B, Leonard CM, Uhl GR, Brusco A, Gardner E. Methods to study the behavioral effects and expression of CB2 cannabinoid receptor and its gene transcripts in the chronic mild stress model of depression. Methods Mol Med 2006;123:291-8.
48. Carlisle SJ, Marciano-Cabral F, Staab A, Ludwick C, Cabral GA. Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. Int Immunopharmacol 2002;2:69-82.