Effect of chronic renal failure on the purinergic responses of corpus cavernosal smooth muscle in rabbits

BJU International

Volumn 90, Issue 6, 2002, Pages 596-600

  Kilicarslan, H ^a   Yildirim, S ^a   Bagcivan, I ^a   Ayan, S ^a   Sarac, B ^a   Sarioglu, Y ^a  

^a CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

Corpus cavernosum; CRF; Impotence; Purinergic relaxation; Rabbit

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; PAPAVERINE; PHENYLEPHRINE; PURINE RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHRONIC KIDNEY FAILURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR DENSITY; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; UREMIA;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; IMPOTENCE; KIDNEY FAILURE, CHRONIC; MALE; MUSCLE, SMOOTH; RABBITS; RECEPTORS, PURINERGIC;

EID: 0036379694     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.2002.02979.x     Document Type: Article

References (29)

1. Lue TF, Tanagho EA. Physiology of erection and pharmacological management of impotence. J Urol 1987; 137: 829-36
2. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 1995; 75: 191-236
3. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. New Engl J Med 1992; 326: 90-2
4. Bush PA, Aronson WJ, Buga GM, Rajfer J, Ignarro LJ. Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J Urol 1992; 147: 1650-5
5. Lincoln TM. Cyclic GMP and mechanisms of vasodilatation. Pharmacol Ther 1989; 41: 479-502
6. Sparwasser C, Drescher P, Will JA, Madsen PO. Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP and cyclic GMP dependent mechanisms. J Urol 1994; 152: 2159-63
7. Synder SH. Adenosine as a neuromodulator. Ann Rev Neurosci 1985; 8: 103-24
8. Mey GD, Vanhoutte PM. Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol 1991; 316: 347-55
9. Busse R, Trogisch G, Bassenge E. The role of endothelium in the control of vascular tone. Basic Res Cardiol 1985; 80: 475-90
10. Dinh Xuan AT, Higenbottam TW, Clelland C, Pepke-Zaba J, Wells FC, Wallwork J. Acetylcholine and adenosine diphosphate cause endothelium-dependent relaxation of isolated human pulmonary arteries. Eur Respir J 1990; 3: 633-8
11. Dalziel HH, Westfall DP. Receptors for adenine nucleotides and nucleosides: subclassification, distribution, and molecular characterization. Pharmacol Rev 1994; 46: 449-66
12. Mantelli L, Amerini S, Ledda F, Forti G, Maggi M. The potent relaxant effect of adenosine in rabbit corpora cavernosa is nitric oxide independent and mediated by A2 receptors. J Androl 1995; 16: 312-7
13. Tong YC, Broderick G, Hypolite J, Levin RM. Correlations of purinergic, cholinergic and adrenergic functions in rabbit corporal cavernosal tissue. Pharmacology 1992; 45: 241-9
14. Katz AM. Endothelium-derived relaxing factor. J Am Coll Cardiol 1988; 12: 797
15. Palmer BF. Sexual dysfunction in uremia. J Am Soc Nephrol 1999; 10: 1381
16. Karacan I, Dervent A, Cunningham G et al. Assessment of nocturnal penile tumescence as an objective method for evaluating sexual functioning in ESRD patients. Dial Transpl 1978; 7: 872
17. Campese VM, Liu CL. Sexual dysfunction in uremia. Endocrine and neurological alterations. Contrib Nephrol 1990; 77: 1
18. Glass CA, Fielding DM, Evans C et al. Factors related to sexual functioning in male patients undergoing hemodialysis and with kidney transplants. Arch Sex Behav 1987; 16: 189
19. Jünemann KP, Persson-Jünemann C, Alken P. Pathophysiology of erectile dysfunction. Sem Urol 1990; 8: 80
20. Gotloib L, Crassweller P, Rodella H et al. Experimental model for studies of continuous peritoneal dialysis in uremic rabbits. Nephron 1982; 31: 254-9
21. Oreopoulos KA, Balaskas VE, Rodela H et al. An animal model for the study of amino acid metabolism in uremia and during peritoneal dialysis. Peritoneal Dial Int 1992; 13: 499-507
22. Braunstein GD. Endocrine causes of impotence. Optimistic outlook for restoration of potency. Postgrad Med 1983; 74: 207
23. Yildirim S, Utkan T, Yildirim K, Sarioglu Y. Effects of exogenous testosterone on isolated rabbit corpus cavernosum penis. Acta Pharmacol Sin 2000; 21: 139-44
24. Yildirim MK, Yildirim S, Utkan T, Sarioglu Y, Yalman Y. Effects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit. Br J Urol 1997; 79: 964-70
25. Wu HY, Broderick GA, Suh JK, Hypolite JA, Levin RM. Effects of purines on rabbit corpus cavernosum contractile activity. Int J Impot Res 1993; 5: 161-7
26. Takahashi Y, Ishii N, Lue TF, Tanagho EA. Effects of adenosine on canine penile erection. J Urol 1992; 148: 1323-5
27. Takahashi Y, Ishii N, Lue TF, Tanagho EA. Pharmacological effects of adenosine on canine penile erection. Tohoku J Exp Med 1991; 165: 49-58
28. Filippi S, Amerini S, Maggi M, Natali A, Ledda F. Studies on the mechanisms involved in the ATP-induced relaxation in human and rabbit corpus cavernosum. J Urol 1999; 161: 326-31
29. Staerman F, Shalev M, Legrand A, Lobel B, Saiag B. P2y and P2x purinoceptors are respectively implicated in endothelium-dependent relaxation and endothelium independent contraction in human corpus cavernosum. Adv Exp Med Biol 2000; 486: 189-95