The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 5, 2009, Pages 881-887

  Innocenti, Federico ^a   Mirkov, Snezana ^a   Nagasubramanian, Ramamoorthy ^a   Ramírez, Jacqueline ^a   Liu, Wanqing ^a   Bleibel, Wasim K ^a   Shukla, Sunita J ^a   Hennessy, Kathleen ^b   Rosner, Gary L ^c   Cook Jr , Edwin ^b   Eileen Dolan, M ^a   Ratain, Mark J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cytotoxicity; Pharmacogenetics; Polymorphism; Topoisomerase inhibitors; Werner's syndrome

Indexed keywords

CAMPTOTHECIN; CARBOPLATIN; CISPLATIN; DAUNORUBICIN; DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; MESSENGER RNA; PLATINUM COMPLEX; WERNER SYNDROME PROTEIN;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EXPOSURE; DRUG SENSITIVITY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; LYMPHOBLASTOID CELL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WERNER SYNDROME;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; B-LYMPHOCYTES; CAMPTOTHECIN; CARBOPLATIN; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CISPLATIN; DAUNORUBICIN; DNA TOPOISOMERASES; ENZYME INHIBITORS; ETOPOSIDE; EXODEOXYRIBONUCLEASES; GENOTYPE; HUMANS; PLATINUM COMPOUNDS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECQ HELICASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; WERNER SYNDROME;

EID: 61449231700     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0793-8     Document Type: Article

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