메뉴 건너뛰기




Volumn 1, Issue 3, 2008, Pages 201-207

Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIREGULIN; TUMOR MARKER;

EID: 61449229208     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-08-0014     Document Type: Article
Times cited : (60)

References (31)
  • 1
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med2004;350: 2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 2
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 3
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" andare associatedwith sensitivity of tumors to gefitinib anderlotinib
    • Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" andare associatedwith sensitivity of tumors to gefitinib anderlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 4
    • 33744788136 scopus 로고    scopus 로고
    • The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targetedtherapies
    • Ji H, Li D, Chen L, et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR- targetedtherapies. Cancer Cell 2006;9:485-95.
    • (2006) Cancer Cell , vol.9 , pp. 485-495
    • Ji, H.1    Li, D.2    Chen, L.3
  • 5
    • 33744814638 scopus 로고    scopus 로고
    • Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor or to down-regulation of the receptors
    • Politi K, Zakowski MF, Fan PD, SchonfeldEA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev 2006; 20:1496-510.
    • (2006) Genes Dev , vol.20 , pp. 1496-1510
    • Politi, K.1    Zakowski, M.F.2    Fan, P.D.3    Schonfeld, E.A.4    Pao, W.5    Varmus, H.E.6
  • 6
    • 33644507072 scopus 로고    scopus 로고
    • Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    • Sato M, Vaughan MB, GirardL, et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 2006;66:2116-28.
    • (2006) Cancer Res , vol.66 , pp. 2116-2128
    • Sato, M.1    Vaughan, M.B.2    Girard, L.3
  • 7
    • 19944427851 scopus 로고    scopus 로고
    • Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer
    • Amann J, Kalyankrishna S, Massion PP, et al. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res 2005;65:226-35.
    • (2005) Cancer Res , vol.65 , pp. 226-235
    • Amann, J.1    Kalyankrishna, S.2    Massion, P.P.3
  • 8
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib- sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib- sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004;305: 1163-7.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 9
    • 14844366111 scopus 로고    scopus 로고
    • ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib- sensitive non-small cell lung cancer cell lines
    • Engelman JA, Janne PA, Mermel C, et al. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib- sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A 2005;102:3788-93.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3788-3793
    • Engelman, J.A.1    Janne, P.A.2    Mermel, C.3
  • 10
    • 33749435816 scopus 로고    scopus 로고
    • Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
    • Engelman JA, Mukohara T, Zejnullahu K, et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J Clin Invest 2006;116:2695-706.
    • (2006) J Clin Invest , vol.116 , pp. 2695-2706
    • Engelman, J.A.1    Mukohara, T.2    Zejnullahu, K.3
  • 11
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 2006;66:5542-8.
    • (2006) Cancer Res , vol.66 , pp. 5542-5548
    • Song, L.1    Morris, M.2    Bagui, T.3    Lee, F.Y.4    Jove, R.5    Haura, E.B.6
  • 12
    • 33847009160 scopus 로고    scopus 로고
    • SRCfamily kinases are activatedin non-small cell lung cancer andpro mote the survival of epidermal growth factor receptor-dependent cell lines
    • Zhang J, Kalyankrishna S, Wislez M, et al. SRCfamily kinases are activatedin non-small cell lung cancer andpro mote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol 2007;170:366-76.
    • (2007) Am J Pathol , vol.170 , pp. 366-376
    • Zhang, J.1    Kalyankrishna, S.2    Wislez, M.3
  • 13
    • 35648965243 scopus 로고    scopus 로고
    • Induction of BIM is essential for apoptosis triggeredby EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
    • Gong Y, Somwar R, Politi K, et al. Induction of BIM is essential for apoptosis triggeredby EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 2007;4:e294.
    • (2007) PLoS Med , vol.4
    • Gong, Y.1    Somwar, R.2    Politi, K.3
  • 14
    • 35648949422 scopus 로고    scopus 로고
    • BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
    • Costa DB, Halmos B, Kumar A, et al. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med2007;4:1669-79.
    • (2007) PLoS Med , vol.4 , pp. 1669-1679
    • Costa, D.B.1    Halmos, B.2    Kumar, A.3
  • 15
    • 35648953299 scopus 로고    scopus 로고
    • Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhancedby BH3 mimetics
    • Cragg MS, Kuroda J, Puthalakath H, Huang DC, Strasser A. Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhancedby BH3 mimetics. PLoS Med 2007;4:1681-9.
    • (2007) PLoS Med , vol.4 , pp. 1681-1689
    • Cragg, M.S.1    Kuroda, J.2    Puthalakath, H.3    Huang, D.C.4    Strasser, A.5
  • 16
    • 37549001026 scopus 로고    scopus 로고
    • Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion
    • Deng J, Shimamura T, Perera S, et al. Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion. Cancer Res 2007;67:11867-75.
    • (2007) Cancer Res , vol.67 , pp. 11867-11875
    • Deng, J.1    Shimamura, T.2    Perera, S.3
  • 17
    • 43249083693 scopus 로고    scopus 로고
    • Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations
    • Choi K, Creighton CJ, Stivers D, Fujimoto N, Kurie JM. Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations. PLoS ONE 2007;2:e1226.
    • (2007) PLoS ONE , vol.2
    • Choi, K.1    Creighton, C.J.2    Stivers, D.3    Fujimoto, N.4    Kurie, J.M.5
  • 18
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005;436:518-24.
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3
  • 19
    • 29244450494 scopus 로고    scopus 로고
    • High expression of ErbB family members andtheir ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor
    • Fujimoto N, Wislez M, Zhang J, et al. High expression of ErbB family members andtheir ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res 2005;65:11478-85.
    • (2005) Cancer Res , vol.65 , pp. 11478-11485
    • Fujimoto, N.1    Wislez, M.2    Zhang, J.3
  • 20
    • 0034671497 scopus 로고    scopus 로고
    • Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated K i-Ras signaling pathway in human colon cancer cells
    • Baba I, Shirasawa S, Iwamoto R, et al. Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activatedK i-Ras signaling pathway in human colon cancer cells. Cancer Res 2000;60:6886-9.
    • (2000) Cancer Res , vol.60 , pp. 6886-6889
    • Baba, I.1    Shirasawa, S.2    Iwamoto, R.3
  • 21
    • 33745791118 scopus 로고    scopus 로고
    • Targeting ADAM-mediated ligand cleavage to inhibit HER3 andEGFR pathways in non-small cell lung cancer
    • Zhou BB, Peyton M, He B, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 andEGFR pathways in non-small cell lung cancer. Cancer Cell 2006;10:39-50.
    • (2006) Cancer Cell , vol.10 , pp. 39-50
    • Zhou, B.B.1    Peyton, M.2    He, B.3
  • 22
    • 0033009389 scopus 로고    scopus 로고
    • Binding specificities andaffinities of egf domains for ErbB receptors
    • Jones JT, Akita RW, Sliwkowski MX. Binding specificities andaffinities of egf domains for ErbB receptors. FEBS Lett 1999;447:227-31.
    • (1999) FEBS Lett , vol.447 , pp. 227-231
    • Jones, J.T.1    Akita, R.W.2    Sliwkowski, M.X.3
  • 23
    • 0032562561 scopus 로고    scopus 로고
    • Epiregulin is a potent pan-ErbB ligandthat preferentially activates heterodimeric receptor complexes
    • Shelly M, Pinkas-Kramarski R, Guarino BC, et al. Epiregulin is a potent pan-ErbB ligandthat preferentially activates heterodimeric receptor complexes. J Biol Chem 1998;273:10496-505.
    • (1998) J Biol Chem , vol.273 , pp. 10496-10505
    • Shelly, M.1    Pinkas-Kramarski, R.2    Guarino, B.C.3
  • 24
    • 0032515186 scopus 로고    scopus 로고
    • A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase- 2 mRNA
    • Ridley SH, Dean JL, Sarsfield SJ, Brook M, Clark AR, Saklatvala J. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase- 2 mRNA. FEBS Lett 1998;439:75-80.
    • (1998) FEBS Lett , vol.439 , pp. 75-80
    • Ridley, S.H.1    Dean, J.L.2    Sarsfield, S.J.3    Brook, M.4    Clark, A.R.5    Saklatvala, J.6
  • 25
    • 0037011121 scopus 로고    scopus 로고
    • Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 andits interaction with cytokine mRNAs
    • Rousseau S, Morrice N, Peggie M, Campbell DG, Gaestel M, Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 andits interaction with cytokine mRNAs. EMBO J 2002;21:6505-14.
    • (2002) EMBO J , vol.21 , pp. 6505-6514
    • Rousseau, S.1    Morrice, N.2    Peggie, M.3    Campbell, D.G.4    Gaestel, M.5    Cohen, P.6
  • 26
    • 0033568608 scopus 로고    scopus 로고
    • The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activatedp rotein kinase 2 andan AU-rich region-targetedmechanism
    • Winzen R, Kracht M, Ritter B, et al. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activatedp rotein kinase 2 andan AU-rich region-targetedmechanism. EMBO J 1999;18:4969-80.
    • (1999) EMBO J , vol.18 , pp. 4969-4980
    • Winzen, R.1    Kracht, M.2    Ritter, B.3
  • 27
    • 18244371651 scopus 로고    scopus 로고
    • Acquiredresistance of lung adenocarcinomas to gefitinib or erlotinib is associatedwi th a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al. Acquiredresistance of lung adenocarcinomas to gefitinib or erlotinib is associatedwi th a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 28
    • 23344440655 scopus 로고    scopus 로고
    • Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
    • Carter TA, Wodicka LM, Shah NP, et al. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A 2005;102: 11011-6.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11011-11016
    • Carter, T.A.1    Wodicka, L.M.2    Shah, N.P.3
  • 29
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation andresistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation andresistance of non-small-cell lung cancer to gefitinib. N Engl J Med2005;352:786-92.
    • N Engl J Med2005 , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 30
    • 19044380618 scopus 로고    scopus 로고
    • Targeting ligand- activated ErbB2 signaling inhibits breast andpr ostate tumor growth
    • Agus DB, Akita RW, Fox WD, et al. Targeting ligand- activated ErbB2 signaling inhibits breast andpr ostate tumor growth. Cancer Cell 2002;2: 127-37.
    • (2002) Cancer Cell , vol.2 , pp. 127-137
    • Agus, D.B.1    Akita, R.W.2    Fox, W.D.3
  • 31


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.