GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells

Molecular Immunology

Volumn 46, Issue 6, 2009, Pages 1031-1041

  Igarashi, Hideya ^a,b   Kuwahara, Kazuhiko ^a,b   Yoshida, Mikoto ^a,b   Xing, Yan ^a,b   Maeda, Kazuhiko ^a,b   Nakajima, Koichi ^c   Sakaguchi, Nobuo ^a,b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Allergy; Arginine methylation; GC B cells; IgE; IL 4; JAK STAT

Indexed keywords

GERMINAL CENTER ASSOCIATED NUCLEAR PROTEIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; JANUS KINASE 1; JANUS KINASE 3; LIPOPOLYSACCHARIDE; MESSENGER RNA; METHYLTRANSFERASE; NUCLEAR PROTEIN; PHOSPHOPROTEIN; PROTEIN ARGININE METHYLTRANSFERASE 5; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; GERMINAL CENTER; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; JANUS KINASE 1; JANUS KINASE 3; METHYLATION; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN METHYLTRANSFERASES; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; UP-REGULATION;

MUS; MUS MUSCULUS;

EID: 61449207854     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.08.272     Document Type: Article

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