Desipramine-induced Ca2+-independent apoptosis in MG63 human osteosarcoma cells: Dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3

Clinical and Experimental Pharmacology and Physiology

Volumn 36, Issue 3, 2009, Pages 297-303

  Lu, Ti ^a   Huang, Chorng Chih ^b   Lu, Yih Chau ^a   Lin, Ko Long ^a   Liu, Shiuh In ^a   Wang, Being Whey ^a   Chang, Po Min ^a   Chen, I Shu ^a   Chen, Sheng Shih ^a   Tsai, Jeng Yu ^a   Chou, Chiang Ting ^a   Jan, Chung Ren ^a  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b TZU HUI INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

Apoptosis; Desipramine; MG63 human osteosacroma cells; Mitogen activated protein kinase; Osteosarcoma; P38

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALCIUM ION; CASPASE 3; DESIPRAMINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OSTEOSARCOMA CELL;

ANTIDEPRESSIVE AGENTS, TRICYCLIC; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CASPASE 3; CELL LINE, TUMOR; CHELATING AGENTS; DESIPRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOSARCOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; TIME FACTORS;

EID: 61349197519     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05065.x     Document Type: Article

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