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Volumn 387, Issue 1, 2009, Pages 92-103

A Self-Scaffolding Model for G Protein Signaling

Author keywords

cell signaling; fluorescence spectroscopy; G protein effectors; G proteins; protein complexes

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA GAMMA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; PHOSPHOLIPASE C BETA1; PHOSPHOLIPASE C BETA2; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

EID: 61349153531     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.01.051     Document Type: Article
Times cited : (4)

References (51)
  • 2
    • 0031026288 scopus 로고    scopus 로고
    • Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases
    • Exton J.H. Cell signalling through guanine-nucleotide-binding regulatory proteins (G proteins) and phospholipases. Eur. J. Biochem. 243 (1997) 10-20
    • (1997) Eur. J. Biochem. , vol.243 , pp. 10-20
    • Exton, J.H.1
  • 3
    • 33947407279 scopus 로고    scopus 로고
    • Expansion of signal transduction by G proteins: the second 15 years or so: from 3 to 16 [alpha] subunits plus [beta][gamma] dimers
    • Birnbaumer L. Expansion of signal transduction by G proteins: the second 15 years or so: from 3 to 16 [alpha] subunits plus [beta][gamma] dimers. Biochim. Biophys. Acta 1768 (2007) 772-793
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 772-793
    • Birnbaumer, L.1
  • 5
    • 0028860268 scopus 로고
    • Heterotrimeric G proteins: organizers of transmembrane signals
    • Neer E.J. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80 (1995) 249-257
    • (1995) Cell , vol.80 , pp. 249-257
    • Neer, E.J.1
  • 6
    • 0030771361 scopus 로고    scopus 로고
    • Role of subunit diversity in signaling by heterotrimeric G proteins
    • Hildebrandt J.D. Role of subunit diversity in signaling by heterotrimeric G proteins. Biochem. Pharmacol. 54 (1997) 325-329
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 325-329
    • Hildebrandt, J.D.1
  • 7
    • 0028860268 scopus 로고
    • Heterotrimeric G proteins: organizers of transmembrane signals
    • Neer E. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80 (1995) 249-257
    • (1995) Cell , vol.80 , pp. 249-257
    • Neer, E.1
  • 8
    • 34249317263 scopus 로고    scopus 로고
    • Stimulation of phospholipase C[beta] by membrane interactions, interdomain movement, and G protein binding-how many ways can you activate an enzyme?
    • Drin G., and Scarlata S. Stimulation of phospholipase C[beta] by membrane interactions, interdomain movement, and G protein binding-how many ways can you activate an enzyme?. Cell. Signalling 19 (2007) 1383-1392
    • (2007) Cell. Signalling , vol.19 , pp. 1383-1392
    • Drin, G.1    Scarlata, S.2
  • 9
    • 46249091922 scopus 로고    scopus 로고
    • Multiple roles of phosphoinositide-specific phospholipase C isozymes
    • Suh P., Park J., Manzoli L., Cocco L., Peak J., Katan M., et al. Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 41 (2008) 415-434
    • (2008) BMB Rep. , vol.41 , pp. 415-434
    • Suh, P.1    Park, J.2    Manzoli, L.3    Cocco, L.4    Peak, J.5    Katan, M.6
  • 10
    • 0033779101 scopus 로고    scopus 로고
    • Structure, function and control of phosphoinositide-specific phospholipase C
    • Rebecchi M., and Pentylana S. Structure, function and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80 (2000) 1291-1335
    • (2000) Physiol. Rev. , vol.80 , pp. 1291-1335
    • Rebecchi, M.1    Pentylana, S.2
  • 11
    • 0029835971 scopus 로고    scopus 로고
    • Phospholipases: structural and functional motifs for working at an interface
    • Roberts M.F. Phospholipases: structural and functional motifs for working at an interface. FASEB J. 10 (1996) 1159-1172
    • (1996) FASEB J. , vol.10 , pp. 1159-1172
    • Roberts, M.F.1
  • 12
    • 0027420246 scopus 로고
    • Role of G proteins in activation of phosphoinositide phospholipase C
    • Exton J.H. Role of G proteins in activation of phosphoinositide phospholipase C. Adv. Second Messenger Phosphoprotein Res. 28 (1993) 65-72
    • (1993) Adv. Second Messenger Phosphoprotein Res. , vol.28 , pp. 65-72
    • Exton, J.H.1
  • 13
    • 0028208759 scopus 로고
    • Phosphoinositide phospholipases and G proteins in hormone action
    • Exton J.H. Phosphoinositide phospholipases and G proteins in hormone action. Annu. Rev. Physiol. 56 (1994) 349-369
    • (1994) Annu. Rev. Physiol. , vol.56 , pp. 349-369
    • Exton, J.H.1
  • 14
    • 0026497385 scopus 로고
    • Regulation of phospholipase C by G proteins
    • Sternweis P.C., and Smrcka A.V. Regulation of phospholipase C by G proteins. Trends Biochem. Sci. 17 (1992) 502-506
    • (1992) Trends Biochem. Sci. , vol.17 , pp. 502-506
    • Sternweis, P.C.1    Smrcka, A.V.2
  • 15
    • 0033514304 scopus 로고    scopus 로고
    • Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-beta effectors
    • Runnels L.W., and Scarlata S.F. Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-beta effectors. Biochemistry 38 (1999) 1488-1496
    • (1999) Biochemistry , vol.38 , pp. 1488-1496
    • Runnels, L.W.1    Scarlata, S.F.2
  • 17
    • 29444446964 scopus 로고    scopus 로고
    • Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
    • Nobles M., Benians A., and Tinker A. Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proc. Natl Acad. Sci. USA 102 (2005) 18706-18711
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 18706-18711
    • Nobles, M.1    Benians, A.2    Tinker, A.3
  • 18
    • 34547124343 scopus 로고    scopus 로고
    • Signaling through a G protein coupled receptor and its corresponding G protein follows a stoichiometrically limited model
    • Philip F., Sengupta P., and Scarlata S. Signaling through a G protein coupled receptor and its corresponding G protein follows a stoichiometrically limited model. J. Biol. Chem. 282 (2007) 19203-19216
    • (2007) J. Biol. Chem. , vol.282 , pp. 19203-19216
    • Philip, F.1    Sengupta, P.2    Scarlata, S.3
  • 19
    • 33747668837 scopus 로고    scopus 로고
    • Stable association between G alpha(q) and phospholipase C beta 1 in living cells
    • Dowal L., Provitera P., and Scarlata S. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. J. Biol. Chem. 281 (2006) 23999-24014
    • (2006) J. Biol. Chem. , vol.281 , pp. 23999-24014
    • Dowal, L.1    Provitera, P.2    Scarlata, S.3
  • 20
    • 0347364629 scopus 로고    scopus 로고
    • Gi protein activation in intact cells involves subunit rearrangement rather than dissociation
    • Bunemann M., Frank M., and Lohse M.J. Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc. Natl Acad. Sci. USA 100 (2003) 16077-16082
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 16077-16082
    • Bunemann, M.1    Frank, M.2    Lohse, M.J.3
  • 22
    • 0035830890 scopus 로고    scopus 로고
    • Visualization of a functional Gαq-green fluorescent protein fusion in living cells
    • Hughes T.E., Zhang H., Logothetis D., and Berlot C.H. Visualization of a functional Gαq-green fluorescent protein fusion in living cells. J. Biol. Chem. 276 (2001) 4227-4235
    • (2001) J. Biol. Chem. , vol.276 , pp. 4227-4235
    • Hughes, T.E.1    Zhang, H.2    Logothetis, D.3    Berlot, C.H.4
  • 24
    • 0035937571 scopus 로고    scopus 로고
    • Receptor-mediated activation of heterotrimeric G-proteins in living cells
    • Janetopoulos C., Jin T., and Devreotes P. Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science 291 (2001) 2408-2411
    • (2001) Science , vol.291 , pp. 2408-2411
    • Janetopoulos, C.1    Jin, T.2    Devreotes, P.3
  • 25
    • 33845219419 scopus 로고    scopus 로고
    • Some G protein heterotrimers physically dissociate in living cells
    • Digby G.J., Lober R.M., Sethi P.R., and Lambert N.A. Some G protein heterotrimers physically dissociate in living cells. Proc. Natl Acad. Sci. USA 103 (2006) 17789-17794
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 17789-17794
    • Digby, G.J.1    Lober, R.M.2    Sethi, P.R.3    Lambert, N.A.4
  • 26
    • 46649102474 scopus 로고    scopus 로고
    • 2+ signal duration through specific interaction with the G{alpha}q family of G proteins
    • 2+ signal duration through specific interaction with the G{alpha}q family of G proteins. J. Cell Sci. 121 (2008) 1363-1372
    • (2008) J. Cell Sci. , vol.121 , pp. 1363-1372
    • Sengupta, P.1    Philip, F.2    Scarlata, S.3
  • 27
    • 0035895355 scopus 로고    scopus 로고
    • Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1
    • Dowal L., Elliott J., Popov S., Wilkie T.M., and Scarlata S. Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1. Biochemistry 40 (2001) 414-421
    • (2001) Biochemistry , vol.40 , pp. 414-421
    • Dowal, L.1    Elliott, J.2    Popov, S.3    Wilkie, T.M.4    Scarlata, S.5
  • 29
    • 51649122031 scopus 로고    scopus 로고
    • G{alpha}q binds two effectors separately in cells: evidence for predetermined signaling pathways
    • Golebiewska U., and Scarlata S. G{alpha}q binds two effectors separately in cells: evidence for predetermined signaling pathways. Biophys. J. 95 (2008) 2575-2582
    • (2008) Biophys. J. , vol.95 , pp. 2575-2582
    • Golebiewska, U.1    Scarlata, S.2
  • 30
    • 61349128706 scopus 로고    scopus 로고
    • Cellular localization of GFP-tagged α subunits. In G Protein Signaling, Methods and Protocols
    • Smrcka A. (Ed), Humana Press, Totowa, NJ
    • Hynes T.R., Hughes T.E., and Berlot C.H. Cellular localization of GFP-tagged α subunits. In G Protein Signaling, Methods and Protocols. In: Smrcka A. (Ed). Methods in Molecular Biology (2004), Humana Press, Totowa, NJ
    • (2004) Methods in Molecular Biology
    • Hynes, T.R.1    Hughes, T.E.2    Berlot, C.H.3
  • 31
    • 0037424517 scopus 로고    scopus 로고
    • Rac2 regulation of phospholipase Cβ2 activity and mode of membrane interactions in intact cells
    • Illenberger D., Walliser C., Strobel J., Gutman O., Niv H., Gaidzik V., et al. Rac2 regulation of phospholipase Cβ2 activity and mode of membrane interactions in intact cells. J. Biol. Chem. 278 (2003) 8645-8652
    • (2003) J. Biol. Chem. , vol.278 , pp. 8645-8652
    • Illenberger, D.1    Walliser, C.2    Strobel, J.3    Gutman, O.4    Niv, H.5    Gaidzik, V.6
  • 32
    • 2642689663 scopus 로고    scopus 로고
    • Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα-GTPγS
    • Tesmer J.J.G., Sunahara R., Gilman A.G., and Sprang S.R. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα-GTPγS. Science 278 (1997) 1907-1916
    • (1997) Science , vol.278 , pp. 1907-1916
    • Tesmer, J.J.G.1    Sunahara, R.2    Gilman, A.G.3    Sprang, S.R.4
  • 33
    • 0037031315 scopus 로고    scopus 로고
    • Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation
    • Medkova M., Preininger A.M., Yu N.J., Hubbell W.L., and Hamm H.E. Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation. Biochemistry 41 (2002) 9962-9972
    • (2002) Biochemistry , vol.41 , pp. 9962-9972
    • Medkova, M.1    Preininger, A.M.2    Yu, N.J.3    Hubbell, W.L.4    Hamm, H.E.5
  • 34
    • 0037159186 scopus 로고    scopus 로고
    • Fluorescence analysis of receptor-G protein interactions in cell membranes
    • Sarvazyan N.A., Lim W.K., and Neubig R.R. Fluorescence analysis of receptor-G protein interactions in cell membranes. Biochemistry 41 (2002) 12858-12867
    • (2002) Biochemistry , vol.41 , pp. 12858-12867
    • Sarvazyan, N.A.1    Lim, W.K.2    Neubig, R.R.3
  • 36
    • 0030982264 scopus 로고    scopus 로고
    • Structure of RGS4 bound to aluminum fluoride-activated G(ialpha1): stabilization of the transition state of GTP hydrolysis
    • Tesmer J., Berman D., Gilman A., and Sprang S. Structure of RGS4 bound to aluminum fluoride-activated G(ialpha1): stabilization of the transition state of GTP hydrolysis. Cell 89 (1997) 251-261
    • (1997) Cell , vol.89 , pp. 251-261
    • Tesmer, J.1    Berman, D.2    Gilman, A.3    Sprang, S.4
  • 37
    • 0032480792 scopus 로고    scopus 로고
    • Regulation of the rate and extent of phospholipase C beta 2 effector activation by the beta gamma subunits of heterotrimeric G proteins
    • Runnels L.W., and Scarlata S.F. Regulation of the rate and extent of phospholipase C beta 2 effector activation by the beta gamma subunits of heterotrimeric G proteins. Biochemistry 37 (1998) 15563-15574
    • (1998) Biochemistry , vol.37 , pp. 15563-15574
    • Runnels, L.W.1    Scarlata, S.F.2
  • 38
    • 0033514304 scopus 로고    scopus 로고
    • Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-β effectors
    • Runnels L.W., and Scarlata S. Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-β effectors. Biochemistry 38 (1999) 1488-1496
    • (1999) Biochemistry , vol.38 , pp. 1488-1496
    • Runnels, L.W.1    Scarlata, S.2
  • 39
    • 0029961069 scopus 로고    scopus 로고
    • q and m1 muscarinic cholinergic receptor: steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation
    • q and m1 muscarinic cholinergic receptor: steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation. J. Biol. Chem. 271 (1996) 7999-8007
    • (1996) J. Biol. Chem. , vol.271 , pp. 7999-8007
    • Biddlecome, G.H.1    Berstein, G.2    Ross, E.M.3
  • 40
    • 0034730628 scopus 로고    scopus 로고
    • Heterologous desensitization mediated by G protein-specific binding to caveolin
    • Murthy K.S., and Makhlouf G.M. Heterologous desensitization mediated by G protein-specific binding to caveolin. J. Biol. Chem. 39 (2000) 30211-30219
    • (2000) J. Biol. Chem. , vol.39 , pp. 30211-30219
    • Murthy, K.S.1    Makhlouf, G.M.2
  • 42
    • 0028963339 scopus 로고
    • Lipid modifications of trimeric G proteins
    • Wedegaertner P., Wilson P., and Bourne H. Lipid modifications of trimeric G proteins. J. Biol. Chem. 270 (1995) 503-506
    • (1995) J. Biol. Chem. , vol.270 , pp. 503-506
    • Wedegaertner, P.1    Wilson, P.2    Bourne, H.3
  • 43
    • 0033587727 scopus 로고    scopus 로고
    • A systematic study of low-resolution recognition in protein-protein complexes
    • Vakser I., Matar O., and Lam C. A systematic study of low-resolution recognition in protein-protein complexes. Proc. Natl Acad. Sci. USA 96 (1999) 8477-8482
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 8477-8482
    • Vakser, I.1    Matar, O.2    Lam, C.3
  • 44
    • 0035977019 scopus 로고    scopus 로고
    • The role of electrostatic interactions in the regulation of the membrane association of G protein βγ heterodimers
    • Murray D., McLaughlin S., and Honig B. The role of electrostatic interactions in the regulation of the membrane association of G protein βγ heterodimers. J. Biol. Chem. 276 (2001) 45153-45159
    • (2001) J. Biol. Chem. , vol.276 , pp. 45153-45159
    • Murray, D.1    McLaughlin, S.2    Honig, B.3
  • 45
    • 0033783132 scopus 로고    scopus 로고
    • GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins
    • Ross E.M., and Wilke T.M. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem. 69 (2000) 1-33
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 1-33
    • Ross, E.M.1    Wilke, T.M.2
  • 46
    • 0030043598 scopus 로고    scopus 로고
    • Mapping of effector binding sites of transducin alpha-subunit using Galpha(t)/Galpha[IMAGE] chimeras
    • Skiba N.P., Bae H., and Hamm H.E. Mapping of effector binding sites of transducin alpha-subunit using Galpha(t)/Galpha[IMAGE] chimeras. J. Biol. Chem. 271 (1996) 413-424
    • (1996) J. Biol. Chem. , vol.271 , pp. 413-424
    • Skiba, N.P.1    Bae, H.2    Hamm, H.E.3
  • 47
    • 0033168166 scopus 로고    scopus 로고
    • Kinetic control of guanine nucleotide binding to soluble Gαq
    • Chiadac P., Mavkin V.S., and Ross E.M. Kinetic control of guanine nucleotide binding to soluble Gαq. Biochem. Pharmacol. 58 (1999) 39-48
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 39-48
    • Chiadac, P.1    Mavkin, V.S.2    Ross, E.M.3
  • 48
    • 4644257143 scopus 로고    scopus 로고
    • Influence of membrane components in the binding of G proteins to membrane surfaces
    • Philip F., and Scarlata S. Influence of membrane components in the binding of G proteins to membrane surfaces. Biochemistry 43 (2004) 11691-11700
    • (2004) Biochemistry , vol.43 , pp. 11691-11700
    • Philip, F.1    Scarlata, S.2
  • 49
    • 0033529292 scopus 로고    scopus 로고
    • Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules
    • Wang T., Pentyala S., Elliott J.T., Dowal L., Gupta E., Rebecchi M.J., and Scarlata S. Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules. Proc. Natl Acad. Sci. USA 96 (1999) 7843-7846
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7843-7846
    • Wang, T.1    Pentyala, S.2    Elliott, J.T.3    Dowal, L.4    Gupta, E.5    Rebecchi, M.J.6    Scarlata, S.7
  • 50
    • 0033514366 scopus 로고    scopus 로고
    • Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins
    • Wang T., Pentyala S., Rebecchi M.J., and Scarlata S. Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins. Biochemistry 38 (1999) 1517-1524
    • (1999) Biochemistry , vol.38 , pp. 1517-1524
    • Wang, T.1    Pentyala, S.2    Rebecchi, M.J.3    Scarlata, S.4
  • 51
    • 77956994950 scopus 로고
    • Determination of the tryptophan content of proteins with N-bromosuccinimide
    • Spade T., and Witkop B. Determination of the tryptophan content of proteins with N-bromosuccinimide. Methods Enzymol. 11 (1967) 498-506
    • (1967) Methods Enzymol. , vol.11 , pp. 498-506
    • Spade, T.1    Witkop, B.2


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