A novel conjugate of low-molecular-weight heparin and Cu,Zn-superoxide dismutase: Study on its mechanism in preventing brain reperfusion injury after ischemia in gerbils

Brain Research

Volumn 1260, Issue , 2009, Pages 76-83

  Qi, Jingzong ^a   Li, Yizhao ^b   Zhang, Hongwei ^a   Cheng, Yanna ^a   Sun, Yongfu ^a   Cao, Jichao ^a   Zhao, Ying ^a   Wang, Fengshan ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Cerebral ischemia; Conjugate; Gerbils; Global; Low molecular weight heparin; Superoxide dismutase

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DNA NUCLEOTIDYLEXOTRANSFERASE; INTERCELLULAR ADHESION MOLECULE 1; LOW MOLECULAR WEIGHT HEPARIN; MALONALDEHYDE; SUPEROXIDE DISMUTASE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN INJURY; BRAIN ISCHEMIA; CAROTID ARTERY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; GERBIL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NERVE CELL; NEUROPROTECTION; NICK END LABELING; NISSL STAINING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; REPERFUSION INJURY; UPREGULATION; ANIMAL; BLOOD; BRAIN; DISEASE MODEL; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION;

ANIMALIA; GERBILLINAE;

ADMINISTRATION, INTRAVENOUS; ANIMALS; APOPTOSIS; BRAIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; GERBILLINAE; HEPARIN, LOW-MOLECULAR-WEIGHT; INTERCELLULAR ADHESION MOLECULE-1; MALONDIALDEHYDE; NEURONS; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 61349148606     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.12.079     Document Type: Article

References (27)

1. Chan P.H. Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21 (2001) 2-14
2. Chan P.H., Kinouchi H., Epstein C.J., Carlson E., Chen S.F., Imaizumi S., and Yang G.Y. Role of superoxide-dismutase in ischemic brain injury-reduction of edema and infarction in transgenic mice following focal cerebral-ischemia. Prog. Brain Res. 96 (1993) 97-104
3. Cui H.F., and Zhang T.M. Study on oral preparation of low-molecular-weight heparin from low anticoagulant activity heparin. Chin. J. Biochem. Pharm. 66 (1993) 10-15
4. Danton G.H., and Dietrich W.D. Inflammatory mechanisms after ischemia and stroke. J. Neuropathol. Exp. Neurol. 62 (2003) 127-136
5. Francis J.W., Ren J.M., Warren L., Brown R.H., and Finklestein S.P. Postischemic infusion of Cu/Zn superoxide dismutase or SOD:Tet451 reduces cerebral infarction following focal ischemia/reperfusion in rats. Exp. Neurol. 146 (1997) 435-443
6. Hermes De Santis E.R., Laumeister B.S., Bansal V., Kataria V., Loomba P., and Sparkman E. Low-molecular-weight heparin in the prevention and treatment of thromboembolic disorders. Dis. Manag. Clin. Outcomes 1 (1998) 166-174
7. Hess D.C., Zhao W., Carroll J., McEachin M., and Buchanan K. Increased expression of ICAM-1 during reoxygenation in brain endothelial-cells. Stroke 25 (1994) 1463-1467
8. Huang J., Upadhyay U.A., and Tamargo R.J. Inflammation in stroke and focal cerebral ischemia. Surg. Neurol. 66 (2006) 232-245
9. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239 (1982) 57-69
10. Maier C.M., Hsieh L., Crandall T., Narasinnhan P., and Chan P.H. A new approach for the investigation of reperfusion-related brain injury. Biochem. Soc. Trans. 34 (2006) 1366-1369
11. Mugge A., Elwell J.H., Peterson T.E., Hofmeyer T.G., Heistad D.D., and Harrison D.G. Chronic treatment with polyethylene-glycolated superoxide-dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ. Res. 69 (1991) 1293-1300
12. Nakane H., Chu Y., Faraci F.M., Oberley L.W., and Heistad D.D. Gene transfer of extracellular superoxide dismutase increases superoxide dismutase activity in cerebrospinal fluid. Stroke 32 (2001) 184-189
13. Noshita N., Sugawara T., Lewen A., Hayashi T., and Chan P.H. Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. Stroke 34 (2003) 1513-1518
14. Oyanagui Y. Evaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal. Biochem. 142 (1984) 290-296
15. Patel M., Day B.J., Crapo J.D., Fridovich I., and McNamara J.O. Requirement for superoxide in excitotoxic cell death. Neuron 16 (1996) 345-355
16. Pulsinelli W.A., Brierley J.B., and Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11 (1982) 491-498
17. Saito A., Hayashi T., Okuno S., Ferrand-Drake M., and Chan P.H. Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the bad cell death signaling pathway. J. Neurosci. 23 (2003) 1710-1718
18. Salas A., Sans M., Soriano A., Reverter J.C., Anderson D.C., Pique J.M., and Panes J. Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism. Gut 47 (2000) 88-96
19. Sugawara T., and Chan P.H. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid. Redox Signal. 5 (2003) 597-607
20. Tsubokawa T., Jadhav V., Solaroglu I., Shiokawa Y., Konishi Y., and Zhang J.H. Lecithinized superoxide dismutase improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Stroke 38 (2007) 1057-1062
21. Turrens J.F., Crapo J.D., and Freeman B.A. Protection against oxygen-toxicity by intravenous-injection of liposome-entrapped catalase and superoxide-dismutase. J. Clin. Invest. 73 (1984) 87-95
22. Wang X., Siren A.L., Liu Y., Yue T.L., Barone F.C., and Feuerstein G.Z. Upregulation of intercellular adhesion molecule 1 (ICAM-1) on brain microvascular endothelial cells in rat ischemic cortex. Brain Res. Mol. Brain Res. 26 (1994) 61-68
23. Wang Q., Tompkins K.D., Simonyi A., Korthuis R.J., Sun A.Y., and Sun G.Y. Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res. 1090 (2006) 182-189
24. Wang Q., Tang X.N., and Yenari M.A. The inflammatory response in stroke. J. Neuroimmunol. 184 (2007) 53-68
25. Warner D.S., Sheng H.X., and Batinic-Haberle I. Oxidants, antioxidants and the ischemic brain. J. Exp. Biol. 207 (2004) 3221-3231
26. 2 radicals in arachidonate-induced increased blood-brain-barrier permeability to proteins. Am. J. Physiol. 251 (1986) H693-H699
27. Zhang H.W., Wang F.S., Shao W., Zheng X.L., Qi J.Z., Cao J.C., and Zhang T.M. Characterization and stability investigation of Cu,Zn superoxide dismutase covalently modified by low molecular weight heparin. Biochemistry (Mosc) 71 (2006) S96-S100