The Asp298 allele of endothelial nitric oxide synthase is a risk factor for myocardial infarction among patients with type 2 diabetes mellitus

BMC Cardiovascular Disorders

Volumn 8, Issue , 2008, Pages

  Odeberg, Jacob ^a,b   Larsson, Charlotte A ^c   Råstam, Lennart ^c   Lindblad, Ulf ^c,d,e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e Skaraborgs Institutet   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ACUTE HEART INFARCTION; AGED; ALLELE; ARTICLE; ATTRIBUTABLE RISK; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; HEART INFARCTION; INFORMATION PROCESSING; MIDDLE AGED; PATHOLOGY; RISK FACTOR;

ALLELES; ASPARTIC ACID; DATA COLLECTION; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NITRIC OXIDE SYNTHASE TYPE III; RISK FACTORS;

EID: 61349128480     PISSN: None     EISSN: 14712261     Source Type: Journal    
DOI: 10.1186/1471-2261-8-36     Document Type: Article

References (42)

1. Creager MA Luscher TF Cosentino F Beckman JA Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part I Circulation 2003, 108(12):1527-1532 10.1161/ 01.CIR.0000091257.27563.32 14504252
2. Forstermann U Janus-faced role of endothelial NO synthase in vascular disease: Uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal Biol Chem 2006, 387(12):1521-1533 10.1515/ BC.2006.190 17132097
3. Cooke GE Doshi A Binkley PF Endothelial nitric oxide synthase gene: prospects for treatment of heart disease Pharmacogenomics 2007, 8(12):1723-1734 10.2217/14622416.8.12.1723 18086002
4. Radomski MW Palmer RM Moncada S Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium Lancet 1987, 2(8567):1057-1058 10.1016/S0140-6736(87)91481-4 2889967
5. Tai SC Robb GB Marsden PA Endothelial nitric oxide synthase: A new paradigm for gene regulation in the injured blood vessel Arterioscler Thromb Vasc Biol 2004, 24(3):405-412 10.1161/01.ATV.0000109171.50229.33 14656742
6. Leighton F Miranda-Rottmann S Urquiaga I A central role of eNOS in the protective effect of wine against metabolic syndrome Cell Biochem Funct 2005
7. Gewaltig MT Kojda G Vasoprotection by nitric oxide: Mechanisms and therapeutic potential Cardiovasc Res 2002, 55(2):250-260 10.1016/ S0008-6363(02)00327-9 12123764
8. Herman AG Moncada S Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis Eur Heart J 2005, 26(19):1945-1955 10.1093/eurheartj/ehi333 15911567
9. Shimasaki Y Yasue H Yoshimura M Nakayama M Kugiyama K Ogawa H Harada E Masuda T Koyama W Saito Y et al Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction J Am Coll Cardiol 1998, 31(7):1506-1510 10.1016/ S0735-1097(98)00167-3 9626827
10. Casas JP Bautista LE Humphries SE Hingorani AD Endothelial nitric oxide synthase genotype and ischemic heart disease: Meta-analysis of 26 studies involving 23028 subjects Circulation 2004, 109(11):1359-1365 10.1161/01.CIR.0000121357.76910.A3 15007011
11. Veldman BA Spiering W Doevendans PA Vervoort G Kroon AA de Leeuw PW Smits P The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide J Hypertens 2002, 20(10):2023-2027 10.1097/00004872-200210000-00022 12359981
12. Vignini A Nanetti L Moroni C Testa R Sirolla C Marra M Cenerelli S Gregori A Fumelli D Olivieri F et al Platelet nitric oxide production and IR: Relation with obesity and hypertriglyceridemia Nutr Metab Cardiovasc Dis 2007
13. Rastam L Berglund G Isacsson SO Ryden L The Skaraborg hypertension project. II. Feasibility of a medical care program for hypertension Acta Med Scand 1986, 219(3):249-260 3706000
14. Bog-Hansen E Lindblad U Bengtsson K Ranstam J Melander A Rastam L Risk factor clustering in patients with hypertension and non-insulin-dependent diabetes mellitus. The Skaraborg Hypertension Project J Intern Med 1998, 243(3):223-232 9627160
15. Ostgren CJ Lindblad U Bog-Hansen E Ranstam J Melander A Rastam L Differences in treatment and metabolic abnormalities between normo- and hypertensive patients with type 2 diabetes: The Skaraborg Hypertension and Diabetes Project Diabetes Obes Metab 1999, 1(2):105-112 10.1046/ j.1463-1326.1999.00018.x 11220508
16. Ostgren CJ Lindblad U Ranstam J Melander A Rastam L Associations between smoking and beta-cell function in a non-hypertensive and non-diabetic population. Skaraborg Hypertension and Diabetes Project Diabet Med 2000, 17(6):445-450 10.1046/j.1464-5491.2000.00294.x 10975213
17. Larsson CA Gullberg B Merlo J Rastam L Lindblad U Female advantage in AMI mortality is reversed in patients with type 2 diabetes in the Skaraborg Project Diabetes Care 2005, 28(9):2246-2248 10.2337/ diacare.28.9.2246 16123500
18. Junga K Merlo J Gullberg B Bog-Hansen E Rastam L Lindblad U Residual risk for acute stroke in patients with type 2 diabetes and hypertension in primary care: Skaraborg Hypertension and Diabetes Project Diabetes Obes Metab 2006, 8(5):492-500 10.1111/j.1463-1326.2005.00534.x 16918583
19. National Board of Health and Welfare DIC Treatment of mild hypertension National Board of Health and Welfare DIC, Stockholm, Sweden: National Board of Health and Welfare 1987:1
20. Committee WHOE Diabetes Mellitus Technical report Geneva: World Health Organisation 1985
21. Lindblad U Rastam L Ranstam J Peterson M Validity of register data on acute myocardial infarction and acute stroke: The Skaraborg Hypertension Project Scand J Soc Med 1993, 21(1):3-9 8469941
22. Merlo J Lindblad U Pessah-Rasmussen H Hedblad B Rastam J Isacsson SO Janzon L Rastam L Comparison of different procedures to identify probable cases of myocardial infarction and stroke in two Swedish prospective cohort studies using local and national routine registers Eur J Epidemiol 2000, 16(3):235-243 10.1023/A:1007634722658 10870938
23. Vandenplas S Wiid I Grobler-Rabie A Brebner K Ricketts M Wallis G Bester A Boyd C Mathew C Blot hybridisation analysis of genomic DNA J Med Genet 1984, 21(3):164-172 1049258 6086927 10.1136/jmg.21.3.164
24. Holmberg K Persson ML Uhlen M Odeberg J Pyrosequencing analysis of thrombosis-associated risk markers Clin Chem 2005, 51(8):1549-1552 10.1373/clinchem.2005.049932 16040857
25. Meigs JB Hu FB Rifai N Manson JE Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus Jama 2004, 291(16):1978-1986 10.1001/jama.291.16.1978 15113816
26. Song Y Manson JE Tinker L Rifai N Cook NR Hu FB Hotamisligil GS Ridker PM Rodriguez BL Margolis KL et al Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women Diabetes 2007, 56(7):1898-1904 1952236 17389327 10.2337/ db07-0250
27. Monti LD Barlassina C Citterio L Galluccio E Berzuini C Setola E Valsecchi G Lucotti P Pozza G Bernardinelli L et al Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome Diabetes 2003, 52(5):1270-1275 10.2337/ diabetes.52.5.1270 12716763
28. Franks PW Luan J Barroso I Brage S Gonzalez Sanchez JL Ekelund U Rios MS Schafer AJ O'Rahilly S Wareham NJ Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance Diabetes 2005, 54(9):2795-2801 10.2337/diabetes.54.9.2795 16123371
29. Conen D Glynn RJ Buring JE Ridker PM Zee RY Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: A prospective cohort study J Intern Med 2008, 263(4):376-385 10.1111/j.1365-2796.2007.01894.x 18069999
30. Gardemann A Lohre J Cayci S Katz N Tillmanns H Haberbosch W The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile Atherosclerosis 2002, 160(1):167-175 10.1016/S0021-9150(01)00554-8 11755935
31. Metzger IF Sertorio JT Tanus-Santos JE Modulation of nitric oxide formation by endothelial nitric oxide synthase gene haplotypes Free Radic Biol Med 2007, 43(6):987-992 10.1016/j.freeradbiomed.2007.06.012 17697943
32. Matthews KA Kuller LH Sutton-Tyrrell K Chang YF Changes in cardiovascular risk factors during the perimenopause and postmenopause and carotid artery atherosclerosis in healthy women Stroke 2001, 32(5):1104-1111 11340217
33. Mendelsohn ME Mechanisms of estrogen action in the cardiovascular system J Steroid Biochem Mol Biol 2000, 74(5):337-343 10.1016/ S0960-0760(00)00110-2 11162942
34. Libby P Managing the risk of atherosclerosis: The role of high-density lipoprotein Am J Cardiol 2001, 88:3N-8N 11788123
35. Yuhanna IS Zhu Y Cox BE Hahner LD Osborne-Lawrence S Lu P Marcel YL Anderson RG Mendelsohn ME Hobbs HH High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase Nat Med 2001, 7(7):853-857 10.1038/89986 11433352
36. Hisamoto K Ohmichi M Kurachi H Hayakawa J Kanda Y Nishio Y Adachi K Tasaka K Miyoshi E Fujiwara N et al Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells J Biol Chem 2001, 276(5):3459-3467 10.1074/jbc.M005036200 11044445
37. Gong M Wilson M Kelly T Su W Dressman J Kincer J Matveev SV Guo L Guerin T Li XA et al HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner J Clin Invest 2003, 111(10):1579-1587 155043 12750408
38. Taddei S Virdis A Ghiadoni L Mattei P Sudano I Bernini G Pinto S Salvetti A Menopause is associated with endothelial dysfunction in women Hypertension 1996, 28(4):576-582 8843881
39. Stampfer MJ Colditz GA Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence Prev Med 1991, 20(1):47-63 10.1016/0091-7435(91)90006-P 1826173
40. Hulley S Grady D Bush T Furberg C Herrington D Riggs B Vittinghoff E Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/ progestin Replacement Study (HERS) Research Group Jama 1998, 280(7):605-613 10.1001/jama.280.7.605 9718051
41. Rossouw JE Anderson GL Prentice RL LaCroix AZ Kooperberg C Stefanick ML Jackson RD Beresford SA Howard BV Johnson KC et al Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial Jama 2002, 288(3):321-333 10.1001/jama.288.3.321 12117397
42. Morawietz H Erbs S Holtz J Schubert A Krekler M Goettsch W Kuss O Adams V Lenk K Mohr FW et al Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: The EPAS trial Circulation 2006, 114:I296-301 10.1161/CIRCULATIONAHA.105.001313 16820589