Menopause is associated with endothelial dysfunction in women

Hypertension

Volumn 28, Issue 4, 1996, Pages 576-582

  Taddei, Stefano ^a   Virdis, Agostino ^a   Ghiadoni, Lorenzo ^a   Mattei, Paola ^a   Sudano, Isabella ^a   Bernini, Gianpaolo ^a   Pinto, Stefania ^a   Salvetti, Antonio ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

aging; endothelium; estrogens; hypertension, essential; menopause

Indexed keywords

ACETYLCHOLINE; ENDOTHELIUM DERIVED RELAXING FACTOR; ESTROGEN; NITROPRUSSIDE SODIUM;

ADULT; AGING; ARTICLE; CONTROLLED STUDY; CORONARY RISK; ENDOTHELIUM CELL; ESSENTIAL HYPERTENSION; ESTROGEN RELEASE; FEMALE; FOREARM BLOOD FLOW; HUMAN; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0029847293     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.28.4.576     Document Type: Article

References (46)

1. Kannel WB, Hjortland MC, McNamara PM. Menopause and the risk of cardiovascular disease: The Framingham Study. Ann Intern Med. 1976;8S:447-456.
2. Barrett-Connor E, Bush TL. Estrogen and coronary heart disease in women. JAMA. 1991;265:1861-1867.
3. Lobo RA. Estrogen and cardiovascular disease. Ann N Y Acad Sci. 1990;592:286-294.
4. Wahl P, Walden C, Knopp R, Hoover J, Wallace R, Heiss G, Rifkind B. Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol. N Engl J Med. 1983;308:862-867.
5. Walsh BW, Schiff I, Rosner B, Greenberg L, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement therapy on the concentrations and metabolism of plasma lipoproteins. N Engl J Med. 1991;325:1196-1204.
6. Collins P, Rosano GMC, Jiang C, Lindsay D, Sarrel PM, Poole-Wilson PA. Hypothesis: cardiovascular protection by oestrogen - a calcium antagonist effect? Lancet. 1993;341:1264-1265.
7. Gisclard V, Miller VM, Vanhoutte PM. Effect of 17β-estradiol on endothelium-dependent responses in the rabbit. J Pharmacol Exp Ther. 1988;244:19-22.
8. Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A. 1992;89:11259-11263.
9. Lüscher TF, Vanhoutte PM. The Endothelium: Modulator of Cardiovascular Function. Boca Raton, Fla: CRC Press; 1990.
10. Furchgott RF. Role of endothelium in response of vascular smooth muscle. Circ Res. 1983;53:557-573.
11. De Mey JG, Vanhoutte PM. Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol. 1981;316:347-355.
12. Lüscher TF, Cooke JP, Houston DS, Neves R, Vanhoutte PM. Endothelium-dependent relaxations in human arteries. Mayo Clin Proc. 1987;62:601-606.
13. Lüscher TF, Diederich D, Siebenmann R, Lehmann K, Stulz P, Von Segesser L, Yang Z, Turina M, Gradel E, Weber E, Bühler FR. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med. 1988;319:462-467.
14. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524-526.
15. Lüscher TF, Vanhoutte PM. Endothelium-dependent contractions to acetylcholine in the aorta of spontaneously hypertensive rats. Hypertension. 1986;8:344-348.
16. Diederich D, Yang Z, Bühler FR, Lüscher TF. Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve the cyclooxygenase pathway. Am J Physiol. 1990;258:H445-H451.
17. 2 in endothelium in maintaining resting tone and producing contractile response to acetylcholine and arachidonic acid in canine cerebral artery. Blood Vessels. 1987;24:117-119.
18. 2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. Hypertension. 1990;15:475-482.
19. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endothelium dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22-27.
20. Taddei S, Virdis A, Mattel P, Salvetti A. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension. 1993;21:929-933.
21. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990; 86:228-234.
22. Zeiher AM, Drexter H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans: effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest. 1993;92:652-662.
23. Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Basile Fasolo C, Sudano I, Salvetti A. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation. 1995;91:1981-1987.
24. Whitney RJ. The measurement of volume changes in human limbs. J Physiol (Lond). 1953;121:1-27.
25. Pedrinelli R, Taddei S, Graziadei L, Salvetti A. Vascular responses to ouabain and norepinephrine in low and normal renin hypertension. Hypertension. 1986;8:786-792.
26. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373-376.
27. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2: 997-1000.
28. Schultz KD, Schultz K, Schultz G. Sodium nitroprusside and other smooth muscle relaxants increase cyclic GMP levels in rat ductus deferens. Nature. 1977;265:750-751.
29. Seber T, Wild C. Nonlinear Regression. New York, NY: John Wiley & Sons; 1989.
30. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 1994;24:471-476.
31. Barr DP, Russ EM, Eder HA. Protein lipid relationships in human plasma. Am J Med. 1952;11:480-493.
32. Stevenson JC, Crook D, Godsland IF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis. 1993;98:83-90.
33. Williams JK, Adams MR, Klopfenstein HB. Estrogen modulates responses of atherosclerotic coronary arteries. Circulation. 1990;81: 1680-1687.
34. Miller VM, Gisclard V, Vanhoutte PM. Modulation of endothelium-dependent and vascular smooth muscle responses by oestyrogens. Phlebology. 1988;3:63-69.
35. Gilligan DM, Quyyumi AA, Cannon RO. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation. 1994;89:2545-2551.
36. Reis SE, Gloth ST, Blumenthal RS, Resar JR, Zacur HA, Gerstenblith G, Brinker JA. Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation. 1994;89:52-60.
37. Collins P, Rosano GMC, Sarrel PM, Ulrich L, Adamopoulos S, Beale CM, McNeill JG, Poole-Wilson PA. 17β-Estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease. Circulation. 1995;92:24-30.
38. Lieberman EH, Gerhard MD, Uehata A, Walsh BW, Selwyn AP, Ganz P, Yeung AC, Creager MA. Estrogen improves endothelium-dependent flow-mediated vasodilation in postmenopausal women. Ann Intern Med. 1994;121:936-941.
39. Rosselli M, Imthurn B, Keller PJ, Jackson EK, Dubey RK. Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17β-estradiol and norethisterone acetate: a 2-year follow-up study. Hypertension. 1995;25:848-853.
40. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Nail Acad Sci U S A. 1994;91:5212-5216.
41. Keaney JF, Shwaery GT, Xu A, Nicoiosi RJ, Loscalzo J, Foxall TL, Vita JA. 17β-Estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation. 1994;89:2251-2259.
42. Tsao PS, McEvoy LM, Drexler H, Butcher EC, Cooke JP. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by Larginine. Circulation. 1994;89:2176-2182.
43. Bath PM, Hassall DG, Gladwin AM, Palmer RM, Martin JF. Nitric oxide and prostacyclin: divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb. 1991;11:254-260.
44. Garg UC, Hassid A. Nitric oxide generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774-1777.
45. Hogan JC, Lewis MJ, Henderson AH. In vivo EDRF activity influences platelet function. Br J Pharmacol. 1988;94:1020-1022.
46. Radomski MW, Palmer RM, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987;2:1057-1058.