Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: A prospective cohort study

Journal of Internal Medicine

Volumn 263, Issue 4, 2008, Pages 376-385

  Conen, D ^a   Glynn, R J ^a   Buring, J E ^a   Ridker, P M ^a   Zee, R Y ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Angiotensin converting enzyme; Diabetes mellitus; Gene polymorphism; Nitric oxide synthase; Renin angiotensin system

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; BODY MASS; CAUCASIAN; COHORT ANALYSIS; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE; FEMALE; FOLLOW UP; GENE; GENETIC RISK; GENOTYPE; HAPLOTYPE; HAZARD RATIO; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; EPIDEMIOLOGIC METHODS; FEMALE; GENOTYPE; HUMANS; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, SINGLE NUCLEOTIDE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RENIN-ANGIOTENSIN SYSTEM; UNITED STATES;

EID: 40349114494     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2007.01894.x     Document Type: Article

References (42)

1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001 414 : 782 7.
2. Danaei G, Lawes CM, Vander Hoorn S, Murray CJ, Ezzati M. Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment. Lancet 2006 368 : 1651 9.
3. Chen NG, Holmes M, Reaven GM. Relationship between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers. J Clin Endocrinol Metab 1999 84 : 3485 9.
4. Song Y, Manson JE, Tinker L, et al. Circulating levels of endothelial adhesion molecules and risk of diabetes mellitus in an ethnically diverse cohort of women. Diabetes 2007 doi:.
5. Meigs JB, Hu FB, Rifai N, Manson JE. Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA 2004 291 : 1978 86.
6. Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006 113 : 1708 14.
7. Carlsson PO, Berne C, Jansson L. Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats. Diabetologia 1998 41 : 127 33.
8. Tikellis C, Wookey PJ, Candido R, Andrikopoulos S, Thomas MC, Cooper ME. Improved islet morphology after blockade of the renin-angiotensin system in the ZDF rat. Diabetes 2004 53 : 989 97.
9. Jacob S, Henriksen EJ, Fogt DL, Dietze GJ. Effects of trandolapril and verapamil on glucose transport in insulin-resistant rat skeletal muscle. Metabolism 1996 45 : 535 41.
10. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990 86 : 1343 6.
11. Danser AH, Schalekamp MA, Bax WA et al. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation 1995 92 : 1387 8.
12. Feng Y, Niu T, Xu X et al. Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes. Diabetes 2002 51 : 1986 8.
13. Grammer TB, Renner W, von Karger S, Boehm BO, Winkelmann BR, Maerz W. The angiotensin-I converting enzyme I/D polymorphism is not associated with type 2 diabetes in individuals undergoing coronary angiography (The Ludwigshafen Risk and Cardiovascular Health Study). Mol Genet Metab 2006 88 : 378 83.
14. Stephens JW, Dhamrait SS, Cooper JA et al. The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects. Mol Genet Metab 2005 84 : 83 9.
15. Rexrode KM, Lee IM, Cook NR, Hennekens CH, Buring JE. Baseline characteristics of participants in the Women's Health Study. J Womens Health Gend Based Med 2000 9 : 19 27.
16. Ridker PM, Cook NR, Lee IM et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005 352 : 1293 304.
17. Lee IM, Cook NR, Gaziano JM et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005 294 : 56 65.
18. Liu S, Lee IM, Song Y et al. Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial. Diabetes 2006 55 : 2856 62.
19. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997 20 : 1183 97.
20. Cheng S, Grow MA, Pallaud C et al. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 1999 9 : 936 49.
21. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003 73 : 1162 9.
22. Stephens M, Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet 2005 76 : 449 62.
23. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001 68 : 978 89.
24. Cox DR. Regression models and life tables. J Roy Stat Soc B 1972 34 : 187 220.
25. Thomas GN, Tomlinson B, Chan JC, Sanderson JE, Cockram CS, Critchley JA. Renin-angiotensin system gene polymorphisms, blood pressure, dyslipidemia, and diabetes in Hong Kong Chinese: a significant association of the ACE insertion/deletion polymorphism with type 2 diabetes. Diabetes Care 2001 24 : 356 61.
26. Hsieh MC, Lin SR, Hsieh TJ et al. Increased frequency of angiotensin-converting enzyme DD genotype in patients with type 2 diabetes in Taiwan. Nephrol Dial Transplant 2000 15 : 1008 13.
27. Perticone F, Ceravolo R, Iacopino S et al. Relationship between angiotensin-converting enzyme gene polymorphism and insulin resistance in never-treated hypertensive patients. J Clin Endocrinol Metab 2001 86 : 172 8.
28. Panahloo A, Andres C, Mohamed-Ali V et al. The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance? Circulation 1995 92 : 3390 3.
29. Chiu KC, McCarthy JE. The insertion allele at the angiotensin I-converting enzyme gene locus is associated with insulin resistance. Metabolism 1997 46 : 395 9.
30. Bennet AM, Di Angelantonio E, Ye Z et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 2007 298 : 1300 11.
31. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000 342 : 145 53.
32. Dahlof B, Devereux RB, Kjeldsen SE et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002 359 : 995 1003.
33. Julius S, Kjeldsen SE, Weber M et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004 363 : 2022 31.
34. Hansson L, Lindholm LH, Niskanen L et al. Effect of angiotensin- converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet 1999 353 : 611 6.
35. Bosch J, Yusuf S, Gerstein HC et al. Effect of ramipril on the incidence of diabetes. N Engl J Med 2006 355 : 1551 62.
36. Inoue I, Nakajima T, Williams CS et al. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 1997 99 : 1786 97.
37. Rotimi C, Cooper R, Ogunbiyi O et al. Hypertension, serum angiotensinogen, and molecular variants of the angiotensinogen gene among Nigerians. Circulation 1997 95 : 2348 50.
38. Monti LD, Barlassina C, Citterio L et al. Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome. Diabetes 2003 52 : 1270 5.
39. Franks PW, Luan J, Barroso I et al. Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance. Diabetes 2005 54 : 2795 801.
40. Kurth T, Gaziano JM, Rexrode KM et al. Prospective study of body mass index and risk of stroke in apparently healthy women. Circulation 2005 111 : 1992 8.
41. Huang PY, Buring JE, Ridker PM, Glynn RJ. Awareness, accuracy, and predictive validity of self-reported cholesterol in women. J Gen Intern Med 2007 22 : 606 13.
42. Conen D, Ridker PM, Buring JE, Glynn RJ. Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study. BMJ 2007 335 : 432.