Platelet nitric oxide production and IR: Relation with obesity and hypertriglyceridemia

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 18, Issue 8, 2008, Pages 553-558

  Vignini, Arianna ^a   Nanetti, Laura ^a   Moroni, Cinzia ^a   Testa, Roberto ^b   Sirolla, Cristina ^b   Marra, Maurizio ^b   Cenerelli, Stefano ^b   Gregori, Alessandro ^b   Fumelli, Daniele ^b   Olivieri, Fabiola ^b   Mazzanti, Laura ^a   Rabini, Rosa Anna ^b  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b INRCA   (Italy)

Author keywords

eNOS polymorphism; Hypertriglyceridemia; Insulin resistance; Nitric oxide; Obesity

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ADULT; ARTICLE; BLOOD; ENZYMOLOGY; GENETIC POLYMORPHISM; GENETICS; GLUCOSE TOLERANCE TEST; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; REFERENCE VALUE; THROMBOCYTE;

ADULT; BLOOD PLATELETS; DIABETES MELLITUS, TYPE 2; GLUCOSE TOLERANCE TEST; HUMANS; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; MALE; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; REFERENCE VALUES;

EID: 51249111780     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2007.08.001     Document Type: Article

References (28)

1. Tooke J. The association between insulin resistance and endotheliopathy. Diabetes Obes Metab 1 (1999) S17-S22
2. Zeng G., and Quon M.J. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in endothelial cells. J Clin Invest 98 (1996) 894-898
3. Aljada A., and Dandona P. Effect of insulin on human aortic endothelial nitric oxide synthase. Metabolism 49 (2000) 147-150
4. Trovati M., Massucco P., Mattiello L., Piretto V., Cavalot F., Mularoni E., et al. The insulin-induced increase of guanosine-3′,5′-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes 45 (1996) 768-770
5. Fleming I., Schulz C., Fichtlscherer B., Kemp B.E., Fisslthaler B., and Busse R. AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost 90 (2003) 863-871
6. Dandona P., Aljada A., Chaudhuri A., Mohanty P., and Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111 (2005) 1448-1454
7. Chakraborty K., and Sinha A.K. The role of insulin as an antithrombotic humoral factor. Bioessays 26 (2004) 91-98
8. Westerbacka J., Yki-Jarvinen H., Turpeinen A., Rissanen A., Vehkavaara S., Syrjala M., et al. Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity. Arterioscler Thromb Vasc Biol 22 (2002) 167-172
9. Ferreira I.A., Mocking A.I., Feijge M.A., Gorter G., van Haeften T.W., Heemskerk J.W., et al. Platelet inhibition by insulin is absent in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 26 (2006) 417-422
10. Angiolillo D.J., Bernardo E., Ramirez C., Costa M.A., Sabate M., Jimenez-Quevedo P., et al. Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment. J Am Coll Cardiol 48 (2006) 298-304
11. Shankar R.R., Wu Y., Shen H.Q., Zhu J.S., and Baron A.D. Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance. Diabetes 49 (2000) 684-687
12. Duplain H., Burcelin R., Sartori C., Cook S., Egli M., Lepori M., et al. Insulin resistance, hyperlipidemia and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 104 (2001) 342-345
13. Wang X.L., Sim A.S., Badenhop R.F., McCredie R.M., and Wilcken D.E. A smoking dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nature Med 2 (1996) 41-45
14. Wattanapitayakul S.K., Mihm M.J., Young A.P., and Bauer J.A. Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism. Trends Pharmacol Sci 22 (2001) 361-368
15. Shimasaki Y., Yasue H., Yoshimura M., Nakayama M., Kugiyama K., Ogawa H., et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with miocardial infarction. J Am Coll Cardiol 31 (1998) 1506-1510
16. Markus H.S., Ruigrok Y., Ali N., and Powell J.F. Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease and carotid atheroma. Stroke 29 (1998) 1908-1911
17. Rabini R.A., Staffolani R., Fumelli P., Mutus B., Curatola G., and Mazzanti L. Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients. Diabetologia 41 (1998) 101-104
18. Graci S. The intravenous insulin tolerance test is an accurate method for screening a general population for insulin resistance and related abnormalities. Endocrinol Invest 22 (1999) 472-475
19. Chakravarthy U., Hayes R.G., Stitt A.W., McAuley E., and Archer D.B. Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products. Diabetes 47 (1998) 945-952
20. Tsukahara H., Gordienko D.V., and Goligorsky M.S. Continuous monitoring of nitric oxide release from human umbilical vein endothelial cells. Biochem Biophys Res Commun 193 (1993) 722-729
21. Yoshimura M., Yasue H., Nakayama M., Shimasaki Y., Ogawa H., Kugiyama K., et al. Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786->C and missense Glu298Asp variants. J Investig Med 48 (2000) 367-374
22. Wang X.L., Sim A.S., Badenhop R.F., McCredie R.M., and Wilcken D.E. A smoking dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med 2 (1996) 41-45
23. Choi J.W., Pai S.H., Kim S.K., Ito M., Park C.S., and Cha Y.N. Increases in nitric oxide concentrations correlate strongly with body fat in obese humans. Clin Chem 47 (2001) 1106-1109
24. Dandona P., Mohanty P., Ghanim H., Aljada A., Browne R., Hamouda W., et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation and protein carbonylation. J Clin Endocrinol Metab 86 (2001) 355-362
25. Dus U.N. Is obesity an inflammatory condition?. Nutrition 17 (2001) 953-956
26. Kapur S., Picard F., Perreault M., Deshaies Y., and Marette A. Nitric oxide: a new player in the modulation of energy metabolism. Int J Obes Relat Metab Disord 24 (2000) S36-S40
27. Mazzanti L., and Mutus B. Diabetes-induced alterations in platelet metabolism. Clin Biochem 7 (1997) 509-515
28. Lind L. Lipids and endothelium-dependent vasodilation - a review. Lipids 37 (2002) 1-15