Changes in astroglial GLT-1 expression after neural transplantation or stab wounds

Experimental Neurology

Volumn 174, Issue 2, 2002, Pages 137-149

  Krum, Janette M ^a   Phillips, Terry M ^b   Rosenstein, Jeffrey M ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b OFS   (United States)

Author keywords

GFAP; Gliosis; Glutamate transporters; Immunoaffinity chromatography; Nestin; Neural grafting

Indexed keywords

EXCITOTOXIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; NESTIN; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN REGION; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MACROGLIA; NERVE CELL NECROSIS; NERVE GRAFT; NERVE TRANSPLANTATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; STAB WOUND;

EID: 0036218668     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.7867     Document Type: Article

References (78)

1. Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds
2. Increased density of excitatory amino acid transport sites in the hippocampal formation following an entorhinal lesion
3. Use of avidin-coated glass beads as a support for high-performance immunoaffinity chromatography
4. Distribution of glutamate transporter subtypes during human brain development
5. Effect of trauma on L-glutamate uptake in cultured astrocytes
6. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
7. Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy
8. Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures
9. Glutamate neurotoxicity and diseases of the nervous system
10. Glutamate receptors and the induction of excitotoxic neuronal death
11. Glutamate neurotoxicity in cortical cell culture
12. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
13. Reactive astrocytes express the embryonic intermediate neurofilament nestin
14. Transplantation of brain tissue in the brain of rat. I. Growth characteristics of neocortical transplants from embryos of different ages
15. Nestin expression in reactive astrocytes following focal cerebral ischemia in rats
16. Histological markers of neuronal, axonal and astrocytic changes after lateral rigid impact traumatic brain injury
17. Expression of glutamate uptake transporters after dibutyryl cyclic AMP differentiation and traumatic injury in cultured astrocytes
18. The role of excitatory amino acids and NMDA receptors in traumatic brain injury
19. Local connections in transplanted and normal cerebral cortex of rats
20. Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury
21. Glutamate transporter protein subtypes are expressed differentially during rat CNS development
22. Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia
23. Regional deafferentation down-regulates subtypes of glutamate transporter proteins
24. Fimbria-fornix transections selectively down-regulate subtypes of glutamate transporter and glutamate receptor proteins in septum and hippocampus
25. Identification of major cell classes in the developing mammalian nervous system
26. Basal forebrain lesions facilitate adult host fiber ingrowth into neocortical transplants
27. Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure
28. Patterns of angiogenesis in neural transplant models: II. Fetal neocortical transplants
29. The fine structure of vascular-astroglial relations in transplanted fetal neocortex
30. VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS
31. Transient coexpression of nestin, GFAP, and vascular endothelial growth factor in mature reactive astroglia following neural grafting or brain wounds
32. Fibrillary astrocytes proliferate in response to brain injury: A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine
33. Down-regulation of glial glutamate transporters after glutamatergic denervation in the rat brain
34. Temporal profile of nestin expression after focal cerebral ischemia in adult rat
35. Differential effects of corticostriatal and thalamostriatal deafferentation on expression of the glutamate transporter GLT1 in the rat striatum
36. Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord
37. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake
38. GLT1, glial glutamate transporter, is transiently expressed in neurons and develops astrocyte specificity only after midgestation in the ovine fetal brain
39. Ischemic disruption of glutamate homeostasis in brain: Quantitative immunocytochemical analyses
40. High performance capillary electrophoresis detection of tissue cytokines
41. Immunoaffinity measurement of recombinant granulocyte colony stimulating factor in patients with chemotherapy-induced neutropenia
42. High-performance capillary electrophoretic analysis of inflammatory cytokines in human biopsies
43. Recycling immunoaffinity chromatography for multiple analyte analysis in biological samples
44. Diminished microtubule-associated protein 2 (MAP2) immunoreactivity following cortical impact brain injury
45. Pathobiology of traumatically induced axonal injury in animals and man
46. The pathobiology of traumatically induced axonal injury in animals and humans: A review of current thoughts
47. Traumatic brain injury down-regulates glial glutamate transporter (GLT-1 and GLAST) proteins in rat brain
48. Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain
49. The astrocytic scar as an impediment to regeneration in the central nervous system
50. Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia
51. Radial glia in the neocortex of adult rats: Effects of neonatal brain injury
52. Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex
53. Developmental expression of neuron-specific enolase immunoreactivity and cytochrome oxidase activity in neocortical transplants
54. Diminished expression of microtubule-associated protein (MAP-2) and beta-tubulin as a putative marker for ischemic injury in neocortical transplants
55. Why do neural transplants survive? An examination of some metabolic and pathophysiological considerations in neural transplantation
56. Cytoskeletal protein immunoexpression in fetal neural grafts: Distribution of phosphorylated and nonphosphorylated neurofilament protein and microtubule-associated protein 2 (MAP-2)
57. The astroglial response to autonomic tissue grafts
58. Glutamate release in severe brain ischaemia is mainly by reversed uptake
59. Glutamate and the pathophysiology of hypoxic - Ischemic brain damage
60. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
61. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
62. Localization of neuronal and glial glutamate transporters
63. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
64. Expression of nestin after traumatic brain injury in rat brain
65. Expression of the glutamate transporter GLT1 in neural cells of the rat central nervous system: Nonradioactive in situ hybridization and comparative immunocytochemistry
66. Connectivity of fetal neocortical block transplants in the excitotoxically ablated cortex of adult rats
67. Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord
68. The CNS lesion scar: New vistas on an old regeneration barrier
69. Glutamate and taurine are increased in ventricular cerebrospinal fluid of severely brain-injured patients
70. Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus
71. Glutamate transporter mRNA expression in proliferative zones of the developing and adult murine CNS
72. Neuronal regulation of glutamate transporter subtype expression in astrocytes
73. Nonvesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake
74. Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus
75. Regional differentiation of dorsal and ventral fetal spinal cord (FSC) transplants into adult rat spinal cord
76. Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression
77. Astrogliosis in culture: I. The model and the effect of antisense oligonucleotides on glial fibrillary acidic protein synthesis