Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive β-amyloid secretion

Genes to Cells

Volumn 14, Issue 3, 2009, Pages 355-369

  Adachi, Atsuhiro ^a   Kano, Fumi ^a,b   Saido, Takaomi C ^c   Murata, Masayuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE 1; CASEIN KINASE IIALPHA; CATION INDEPENDENT MANNOSE 6 PHOSPHATE RECEPTOR; CDC42 INDING PROTEIN KINASE BETA; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC ALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC GAMMA; CYTOPLASMIC LINKER PROTEIN ASSOCIATING PROTEIN 2; GLYCOGEN SYNTHASE KINASE 3BETA; MEMBRANE PROTEIN; PHOSPHOTRANSFERASE; PROTEIN KINASE; SMALL INTERFERING RNA; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CATION TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME REGULATION; FLUORESCENCE; GENE LIBRARY; GENE SILENCING; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MICROTUBULE ASSEMBLY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; RNA INTERFERENCE; SCREENING; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; HUMANS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN TRANSPORT;

EID: 61349110197     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2008.01274.x     Document Type: Article

References (43)

1. Akhmanova, A., Hoogenraad, C.C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., Vermeulen, W., Burgering, B.M., De Zeeuw, C.I., Grosveld, F. & Galjart, N. (2001) CLASPs are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblast. Cell 23, 923-935.
2. Arighi, C.N., Hartnell, L.M., Aguilar, R.C., Haft, C.R. & Bonifacino, J.S. (2004) Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J. Cell Biol. 165, 123-133.
3. Balklava, Z., Pant, S., Fares, H. & Grant, B.D. (2007) Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Nat. Cell Biol. 9, 1066-1073.
4. Cataldo, A.M., Barnett, J.L., Pieroni, C. & Nixon, R.A. (1997) Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased β-amyloidogenesis. J. Neurosci. 17, 6142-6151.
5. Cheng, T.S., Hsiao, Y.L., Lin, C.C., Yu, C.T., Hsu, C.M., Chang, M.S., Lee, C.I., Huang, C.Y., Howng, S.L. & Hong, Y.R. (2008) Glycogen synthase kinase 3β interacts with and phosphorylates the spindle-associated protein Astrin*. J. Biol. Chem. 283, 2454-2464.
6. Conde, S., Pérez, D.I., Martínez, A., Perez, C. & Moreno, F.J. (2003) Thienyl and phenyl α-halomethyl ketones: New inhibitors of glycogen synthase kinase (GSK-3β) from a library of compound searching. J. Med. Chem. 46, 4631-4633.
7. Dangi, S. & Shapiro, P. (2005) Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis. J. Biol. Chem. 280, 24524-24531.
8. Derby, M.C., Lieu, Z.Z., Brown, D., Stow, J.L., Goud, B. & Gleeson, P.A. (2007) The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic 8, 758-773.
9. Efimov, A., Kharitonov, A., Efimova, N., Loncarek, J., Miller, P.M., Andreyeva, N., Gleeson, P., Galjart, N., Maia, A.R., McLeod, I.X., Yates, J.R., Maiato, H., Khodjakov, A., Akhmanova, A. & Kaverina, I. (2007) Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Dev. Cell 12, 917-930.
10. Ehehalt, R., Keller, P., Haass, C., Thiele, C. & Simons, K. (2003) Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts. J. Cell Biol. 160 113-123.
11. Fernández-Medarde, A., Porteros, A., de, las, Rivas, J., Nú̃ez, A., Fuster, J.J. & Santos, E. (2007) Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning. Neuroscience 146, 272-85.
12. Fumoto, K., Hoogenraad, C.C. & Kikuchi, A. (2006) GSK-3b-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25, 5670-5682.
13. Ghosh, P., Griffith, J., Geuze, H.J. & Kornfeld, S. (2003) Mammalian GGAs act together to sort mannose 6-phosphate receptors. J. Cell Biol. 163, 755-766.
14. Gomes, E.R., Jani, S. & Gundersen, G.G. (2005) Nuclear movement regulated by Cdc42, MRCK, Myosin, and Actin flow establishes MTOC polarization in migrating cells. Cell 121, 451-463.
15. Hattori, C., Asai, M., Onishi, H., Sasagawa, N., Hashimoto, Y., Saido, T.C., Maruyama, K., Mizutani, S. & Ishiura, S. (2006) BACE1 interacts with lipid raft proteins. J. Neurosci. Res. 84, 912-917.
16. He, X., Li, F., Chang, W.P. & Tang, J. (2005) GGA proteins mediate the recycling pathway of Memapsin 2 (BACE). J. Biol. Chem. 280, 11696-11703.
17. Hirosako, K., Imasato, H., Hirota, Y., Kuronita, T., Masuyama, N., Nishioka, M., Umeda, A., Fujita, H., Himeno, M. & Tanaka, Y. (2004) 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phospate/insulin-like growth factor II receptor from the early endosome to the TGN. Biochem. Biophys. Res. Commun. 316, 845-582.
18. Kar, S., Poirier, J., Guevara, J., Dea, D., Hawkes, C., Robitaille, Y. & Quirion, R. (2006) Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology. Neurobiol. Aging 27, 199-210.
19. Kierbel, A., Gassama-Diagne, A., Mostov, K. & Engel, J.N. (2005) The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization. Mol. Biol. Cell 16, 2577-2585.
20. Lee, Y.S., Paek, K.S., Kang, E.S., Jang, H.S., Kim, H.J., Kang, Y.J., Kim, J.H., Lee, H.T., Lee, J.H., Chang, K.C., Nishinaka, T. & Seo, H.G. (2005) Involvement of nuclear factor kB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells. Int. J. Biochem. Cell Biol. 37, 2297-2309.
21. Mathews, P.M., Guerra, C.B., Jiang, Y., Grbovic, O.M., Kao, B.H., Schmidt, S.D., Dinakar, R., Mercken, M., Hille-Rehfeld, A., Rohrer, J., Mehta, P., Cataldo, A.M. & Nixon, R.A. (2002) Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Aβ secretion. J. Biol. Chem. 277, 5299-5307.
22. Mimori-Kiyosue, Y., Grigoriev, I., Lansbergen, G., Sasaki, H., Matsui, C., Severin, F., Galjart, N., Grosveld, F., Vorobjev, I., Tsukita, S. & Akhmanova, A. (2005) CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. J. Cell Biol. 168, 141-153.
23. Noble, W., Planel, E., Zehr, C., Olm, V., et al. (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc. Natl Acad. Sci. USA 102, 6990-6995.
24. Pelkmans, L., Fava, E., Grabner, H., Hannus, M., Habermann, B., Krausz, E. & Zerial, M. (2005) Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature 436, 78-86.
25. Phiel, C.J., Wilson, C.A., Lee, V.M. & Klein, P.S. (2003) GSK-3b regulates production of Alzheimer's disease amyloid-β peptides. Nature 423, 435-439.
26. Rajendran, L., Honsho, M., Zahn, T.R., Keller, P., Geiger, K.D., Verkade, P. & Simons, K. (2006) Alzheimer's disease β-amyloid peptides and released in association with exosomes. Proc. Natl Acad. Sci. USA 103, 11172-11177.
27. Reddy, J.V., Burguete, A.S., Sridevi, K., Ganley, I.G., Nottingham, R.M. & Pfeffer, S.R. (2006) A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling. Mol. Cell. Biol. 10, 4353-4363.
28. Rockenstein, E., Torrance, M., Adame, A., Mante, M., Bar-on, P., Rose, J.B., Crews, L. & Masliah, E. (2007) Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J. Neurosci. 27, 1981-1991.
29. Saido, T.C. & Iwata, N. (2006) Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci. Res. 54, 235-253.
30. Saucerman, J.J., Zhang, J., Martin, J.C., Peng, L.X., Stenbit, A.E., Tsien, R.Y. & McCulloch, A.D. (2006) Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc. Natl Acad. Sci. USA 103, 12923-12928.
31. Schermer, B., Höpker, K., Omran, H., et al. (2005) Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J. 24, 4415-4424.
32. Scott, G.K., Fei, H., Thomas, L., Medigeshi, G.R. & Thomas, G. (2006) A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking. EMBO J. 25, 4423-4435.
33. Shiba, T., Kametaka, S., Kawasaki, M., Shibata, M., Waguri, S., Uchiyama, Y. & Wakatsuki, S. (2004) Insights into the phosphoregulation of β-secretase sorting signal by the VHS domain of GGA1. Traffic 5, 437-448.
34. Small, S.A., Kent, K., Pierce, A., Leung, C., Kang, M.S., Okada, H., Honig, L., Vonsattel, J.P. & Kim, T.W. (2005) Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann. Neurol. 58, 909-919.
35. Su, Y., Ryder, J. & Ni, B. (2003) Inhibition of Aβ production and APP maturation by a specific PKA inhibitor. FEBS lett. 546, 407-410.
36. Tesco, G., Koh, Y.H., Kang, E.L., Cameron, A.N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.H., Zhong, Z., Shen, Y., Simpkins, J.W. & Tanzi, R.E. (2007) Depletion of GGA3 stabilizes BACE and enhances β-secretase activity. Neuron 54, 721-737.
37. Tomiyama, Y., Waguri, S., Kanamori, S., Kametaka, S., Wakasugi, M., Shibata, M., Ebisu, S. & Uchiyama, Y. (2004) Early-phase redistribution of the cation-independent mannose 6-phosphate receptor by U18666A treatment in Hela cells. Cell Tissue Res. 317, 253-264.
38. Waguri, S., Tomiyama, Y., Ikeda, H., Hida, T., Sakai, N., Taniike, M., Ebisu, S. & Uchiyama, Y. (2006) The luminal domain participates in the endosomal trafficking of the cation-independent mannose 6-phosphate receptor. Exp. Cell Res. 312, 4090-4107.
39. Wang, J.Z., Grundke-Iqbal, I. & Iqbal, K. (2007) Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur. J. Neurosci. 25, 59-68.
40. Weidemann, A., König, G., Bunke, D., Fischer, P., Salbaum, J.M., Masters, C.L. & Beyreuther, K. (1989) Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
41. Wilkinson, S., Paterson, H.F. & Marshall, C.J. (2005) Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat. Cell Biol. 7, 255-261.
42. Wittmann, T. & Waterman-Storer, C.M. (2005) Spatial regulation of CLASP affinity for microtubules by Rac1 and GSKb in migrating epithelial cells. J. Cell Biol. 169, 929-939.
43. Wong, W. & Scott, J.D. (2004) AKAP signaling complexes: Focal points in space and time. Nat. Rev. Mol. Cell Biol. 5, 959-970.