Acute effects of combining citalopram and pindolol on regional brain serotonin synthesis in sham operated and olfactory bulbectomized rats

Neurochemistry International

Volumn 54, Issue 3-4, 2009, Pages 161-171

  Nguyen, Khanh Q ^a   Tohyama, Yoshihiro ^a   Watanabe, Arata ^a   Hasegawa, Shu ^a   Skelin, Ivan ^a   Diksic, Mirko ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b JOSIP JURAJ STROSSMAYER UNIVERSITY OF OSIJEK   (Croatia)

Author keywords

5 HT autoreceptor; Citalopram; Olfactory bulbectomy; Pindolol; Serotonin; SSRI

Indexed keywords

AUTORECEPTOR; CITALOPRAM; N METHYLTRYPTOPHAN; PINDOLOL; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SODIUM CHLORIDE;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DEPRESSION; DORSAL RAPHE NUCLEUS; DRUG EFFECT; FEEDBACK SYSTEM; MALE; MEDIAN RAPHE NUCLEUS; NONHUMAN; OLFACTORY BULBECTOMY; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SEROTONIN METABOLISM; SEROTONIN RELEASE; SEROTONINERGIC TRANSMISSION; SHAM PROCEDURE;

ANIMALS; AUTORECEPTORS; BRAIN; CITALOPRAM; DENERVATION; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEEDBACK, BIOCHEMICAL; MALE; OLFACTORY BULB; PINDOLOL; PRESYNAPTIC TERMINALS; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SYNAPTIC TRANSMISSION;

RATTUS;

EID: 60949083348     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.08.012     Document Type: Article

References (99)

1. 1B receptors in the regulation of serotonin cell firing and release in the rat brain. J. Neurochem. 79 (2001) 172-182
2. Artigas F. 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol. Sci. 14 (1993) 262-1262
3. Artigas F., Celada P., Laruelle M., and Adell A. How does pindolol improve antidepressant action?. Trends Pharmacol. Sci. 22 (2001) 224-228
4. Azmitia E.C., and Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179 (1978) 641-667
5. Ballesteros J., and Callado L.F. Effectiveness of pindolol plus serotonin uptake inhibitors in depression: a meta-analysis of early and late outcomes from randomised controlled trials. J. Affect. Disord. 79 (2004) 137-147
6. Baldessarini R.J., Marsh E.R., and Kula N.S. Interactions of fluoxetine with metabolism of dopamine and serotonin in rat brain regions. Brain Res. 579 (1992) 152-156
7. 1B/D autoreceptors. Synapse 31 (1999) 13-19
8. 11C]methyl-l-Tryptophan PET study. Neurochem. Int. 52 (2008) 701-708
9. Björklund A., Wiklund L., and Descarries L. Regeneration and plasticity of central serotoninergic neurons: a review. J. Physiol. (Paris) 77 (1981) 247-255
10. Blier P. The pharmacology of putative early-onset antidepressant strategies. Eur. Neuropsychopharmacol. 13 (2003) 57-66
11. Blier P., and Bergeron R. Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. J. Clin. Psychopharmacol. 15 (1995) 217-222
12. Blier P., de Montigny C., and Chaput Y. A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. J. Clin. Psychiatry 51 (1990) 14-20
13. 1 receptor agonists and ρ-chloroamphetamine. Synapse 5 (1990) 120-133
14. Bloxam D.L., and Curzon G. A study of proposed determinants of brain tryptophan concentration in rats after portocaval anastomosis or sham operation. J. Neurochem. 31 (1978) 1255-1263
15. Boadle-Biber M.C. Regulation of serotonin synthesis. Prog. Biophys. Mol. Biol. 60 (1993) 1-15
16. Bosker F.J., Cremers T.I.F.H., Jongsma M.E., Westerink B.H.C., Wikstrom H.V., and den Boer J.A. Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine1A receptor-mediated feedback: a microdialysis study in the amygdala. J. Neurochem. 76 (2001) 1645-1653
17. Bourin M., Redrobe J.P., and Baker G.B. Pindolol does not act only on 5-HT1A receptors in augmenting antidepressant activity in the mouse forced swimming test. Psychopharmacology (Berl.) 136 (1998) 226-234
18. Brown P., and Molliver M.E. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. J. Neurosci. 20 (2000) 1952-1963
19. Cairncross K.D., King M.G., and Schofield S.P.M. Effect of amitriptyline on avoidance learning in rats following olfactory bulb ablation. Pharmacol. Biochem. Behav. 3 (1975) 1063-1067
20. 1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. Br. J. Pharmacol. 122 (1997) 733-741
21. Chaput Y., de Montigny C., and Blier P. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 333 (1986) 342-348
22. Chugani D.C., and Muzik O. Alpha[C-11]methyl-l-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J. Cereb. Blood Flow Metab. 20 (2000) 2-9 (Review)
23. Cryan J.F., Markou A., and Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol. Sci. 23 (2002) 238-245
24. Cryan J.F., McGrath C., Leonard B.E., and Norman T.R. Combining pindolol and paroxetine in an animal model of chronic antidepressant action-can early onset of action be detected?. Eur. J. Pharmacol. 352 (1998) 23-28
25. Cryan J.F., Mcgrath C., Leonard B.E., and Norman T.R. Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. Pharmacol. Biochem. Behav. 63 (1999) 333-338
26. David D.J.P., Bourin M., Jego G., Przybylski C., Jolliet P., and Gardier A.M. Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice. Br. J. Pharmacol. 140 (2003) 1128-1136
27. Dawson L.A., and Nguyen H.Q. The role of 5-HT1A and 5-HT1B/1D receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (±)pindolol. Neuropharmacology 39 (2000) 1044-1052
28. Diksic M. Labelled alpha-methyl-l-tryptophan as a tracer for the study of the brain serotonergic system. J. Psychiatry Neurosci. 26 (2001) 293-303
29. Diksic M., Nagahiro S., Sourkes T.L., and Yamamoto Y.L. A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J. Cereb. Blood Flow Metab. 10 (1990) 1-12
30. Diksic M., and Young S.N. Study of the brain serotonergic system with labeled alpha-methyl-l-tryptophan. J. Neurochem. 78 (2000) 1185-1200
31. Earley B., and Glennon M. Autoradiographic distribution of cholinergic muscarinic receptors and serotonin 2 receptors in olfactory bulbectomized rats after chronic treatment with mianserin and desipramine. Hum. Psychopharm. 9 (1994) 397-407
32. Fedi M., Reutens D., Okazawa H., Andermann F., Boling W., Dubeau F., White C., Nakai A., Gross D.W., Andermann E., and Diksic M. Localizing value of α-methyl-l-tryptophan PET in intractable epilepsy of neocortical origin. Neurology 57 (2001) 1629-1636
33. Gobert A., and Millan M.J. Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats. Neuropharmacology 38 (1999) 315-317
34. Grecksch G., Zhou D., Franke C., Schroder U., Sabel B., Becker A., and Huether G. Influence of olfactory bulbectomy and subsequent imipramine treatment on 5-hydroxytryptaminergic presynapses in the rat frontal cortex: behavioral correlates. Br. J. Pharmacol. 122 (1997) 1725-1731
35. Haddjeri N., and Blier P. Effects of sustained (±)pindolol administration on serotonin neurotransmission in rats. J. Psychiatry Neurosci. 25 (2000) 378-388
36. Hadrava V., Blier P., and de Montigny C. Partial agonistic activity of R- and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors. J. Psychiatry Neurosci. 21 2 (1996) 101-108
37. Hasegawa S., Watanabe A., Nguyen K.Q., Debonnel G., and Diksic M. Chronic administration of citalopram in olfactory bulbectomy rats restores brain 5-HT synthesis rates: an autoradiographic study. Psychopharmacology 179 (2005) 781-790
38. 1B receptor agonist reduces serotonin synthesis following acute, and not chronic, drug administration: results of an autoradiographic study. Neurochem. Int. 46 (2005) 261-272
39. Hervás I., Bel N., Fernández A.G., Palacios J.M., and Artigas F. In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei. Naunyn-Schmiedeberg's Arch. Pharmacol. 358 (1998) 315-322
40. Hjorth S., Bengtsson H.J., Kullberg A., Carlzon D., Peilot H., and Auerbach S.B. Serotonin autoreceptor function and antidepressant drug action. J. Psychopharmacol. 14 (2000) 177-185
41. 1A receptors or β-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo. Eur. J. Pharmacol. 316 (1996) 43-47
42. 1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. Life Sci. 48 (1991) 1779-1786
43. Hjorth S., Suchowski C.S., and Galloway M.P. Evidence for 5-HT autoreceptor-mediated, nerve impulse-independent, control of 5-HT synthesis in the rat brain. Synapse 19 (1995) 170-176
44. Huether G., Zhou D., and Ruther E. Long-term modulation of presynaptic 5-HT-output: experimentally induced changes in cortical 5-HT transporter density, tryptophan hydroxylase content and 5-HT innervation density. J. Neural Trans. 104 (1997) 993-1004
45. Hyttel J. Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs). Int. Clin. Psychopharmacol. 1 (1994) 19-26
46. Invernizzi R., Belli S., and Samanin R. Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res. 584 (1992) 322-324
47. Invernizzi R., Carli M., Di Clemente A., and Samanin R. Administration of 8-hydroxy-2-(di-n-propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in the rat brain: differences in potency and regional sensitivity. J. Neurochem. 56 (1991) 243-247
48. 1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology 36 (1997) 467-473
49. Janscar S.M., and Leonard B.E. Changes in neurotransmitter metabolism following olfactory bulbectomy in the rat. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 8 (1984) 263-2269
50. Jesberger A., and Richardson J. Brain output dysregulation induced by olfactory bulbectomy: an approximation in the rat of major depressive disorder in humans. Int. J. Neurosci. 38 (1988) 241-265
51. Kelly J.P. The olfactory bulbectomized rat as a model of depression. Pharmacol. Ther. 74 (1997) 299-316
52. Kim S.W., Park S.Y., and Hwang O. Up-regulation of tryptophan hydroxylase expression and serotonin synthesis by sertraline. Mol. Pharmacol. 61 (2002) 778-785
53. Kosofsky B.E., and Molliver M.E. The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse 1 (1987) 153-168
54. Kugelberg F.C., Apelqvist G., Carlsson B., Ahlner J., and Bengtsson F. In vivo steady-state pharmacokinetic outcome following clinical and toxic doses of racemic citalopram to rats. Br. J. Pharmacol. 132 (2001) 1683-1690
55. Long J.B., Youngblood W.Y., and Kizer J.S. Regional differences in the response of serotonergic neurons in rat CNS to drugs. Eur. J. Pharmacol. 88 (1983) 89-97
56. Lumia A.R., Teicher M.H., Salchli F., Ayers E., and Possidente B. Olfactory bulbectomy as a model for agitated hyposerotonergic depression. Brain Res. 587 (1992) 181-185
57. Martinez D., Hwang D., Mawlawi O., et al. Differential occupancy of somatodendritic and postsynaptic 5HT(1A) receptors by pindolol: a dose-occupancy study with [11C]WAY 100635 and positron emission tomography in humans. Neuropsychopharmacology 24 (2001) 209-229
58. McQuade R., and Sharp T. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J. Neurochem. 69 (1997) 791-796
59. Mück-Šeler D., Jevric-Causevic A., and Diksic M. Influence of fluoxetine on regional serotonin synthesis in the rat brain. J. Neurochem. 67 (1996) 2434-2442
60. Nagahiro S., Takada A., Diksic M., Sourkes T.L., Missala K., and Yamamoto Y.L. A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats. J. Cereb. Blood Flow Metab. 10 (1990) 13-21
61. Nishikawa M., Kumakura Y., Young S.N., Fiset P., Vogelzangs N., Leyton M., Benkelfat C., and Diksic M. Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-[(11)C]methyl-l-tryptophan and positron emission tomography. Neurochem. Int. 47 (2005) 556-564
62. Nishisawa S., Mzengeza S., and Diksic M. Acute effects of 3,4-methylenedioxymethamphetamine on brain serotonin synthesis in the dog studied by positron emission tomography. Neurochem. Int. 34 (1999) 33-40
63. Nishizawa S., Benkelfat C., Young S.N., Leyton M., Mzengeza S., de Montigny C., Blier P., and Diksic M. Differences between males and females in rates of serotonin synthesis in human brain. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 5308-5313
64. Norrholm S.D., and Ouimet C.C. Altered dendritic spine density in animal models of depression in response to antidepressant treatment. Synapse 42 (2001) 151-163
65. O'Hearn E., and Molliver M.E. Organization of raphe-cortical projections in rat: a quantitative retrograde study. Brain Res. Bull. 13 (1984) 709-726
66. O'Leary O.F., Bechtholt A.J., Crowley J.J., Valentino R.J., and Lucki I. The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugs. Eur. Neuropsychopharmacol. 17 (2007) 215-226
67. Okazawa H., Yamane F., Blier P., and Diksic M. Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain. J. Neurochem. 72 (1999) 2022-2031
68. Owens M.J., Knight D.L., and Nemeroff C.B. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol. Psychiatry 50 (2001) 345-350
69. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1986), Academic Press, New York
70. Pazos A., and Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346 (1985) 205-230
71. Redmond A.M., Kelly J.P., and Leonard B.E. Behavioural and neurochemical effects of dizocilpine in the olfactory bulbectomized rat model of depression. Pharmacol. Biochem. Behav. 58 (1997) 355-359
72. 1B serotonin receptors in adult rat brain. J. Comp. Neurol. 417 (2000) 181-194
73. Roche M., Harkin A., and Kelly J.P. Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat. Neuropsychopharmacology 32 (2007) 1312-1320
74. 1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. J. Neurochem. 68 (1997) 2593-2603
75. 1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology 15 (1996) 349-360
76. 11C]methyl-l-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Arch. Gen. Psychiatry 61 (2004) 556-563
77. Rutter J.J., and Auerbach S.B. Acute uptake inhibition increases extracellular serotonin in the rat forebrain. J. Pharmacol. Exp. Ther. 265 (1993) 1319-1324
78. Salter M., Knowles R.G., and Pogson C.I. How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain?. Biochem. J. 262 (1989) 365-368
79. Sari Y. Serotonin1B receptors: from protein to physiological function and behavior. Neurosci. Biobehav. Rev. 28 (2004) 565-582 (Review)
80. Sato H., Skelin I., Debonnel G., and Diksic M. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain Res. Bull. 75 (2008) 545-555
81. Sinton C.M., and Fallon S.L. Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor. Eur. J. Pharmacol. 157 (1988) 173-181
82. Skelin I., Yamane F., and Diksic M. Flesinoxan challenge suggests that chronic treatment with paroxetine in rats does not desensitize receptors controlling 5-HT synthesis. Nerochem. Int. 53 68 (2008) 236-243
83. Song C., and Leonard B.E. Changes in behaviour, neurotransmitters and neutrophil function in olfactory bulbectomized rats: effects of chronic desipramine treatment. Hum. Psychopharmacol. 12 (1997) 99-103
84. Spoont M.R. Modulatory role of serotonin in neural information processing: implications for human psychopathology. Psychol. Bull. 112 (1992) 330-350 Review
85. Stahl S.M. Placebo-controlled comparison of the selective serotonin reuptake inhibitors citalopram and sertraline. Biol. Psychiatry 48 (2000) 894-901
86. Tatarczyńska E., Kłodzińska A., and Chojnacka-Wójcik E. Effects of combined administration of 5-HT1A and/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats. Pol. J. Pharmacol. 54 (2002) 615-623
87. Tohyama Y., Yamane F., Fikre Merid M., Blier P., and Diksic M. Effects of serotonine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study. J. Neurochem. 80 (2002) 788-798
88. 14C]methyl-l-tryptophan. Eur. Neuropsychopharmacol. 11 (2001) 193-202
89. Tohyama Y., Mück-Šeler D., and Diksic M. Acute flesinoxan treatment produces a different effect on rat brain serotonin synthesis than chronic treatment: an α-methyl-l-tryptophan autoradiographic study. Neurochem. Int. 51 (2007) 486-495
90. Tsuchihashi H., Nakashima Y., Kinami J., and Nagatomo T. Characteristics of 125I-iodocyanopindolol binding to beta-adrenergic and serotonin-1B receptors of rat brain: selectivity of beta-adrenergic agents. Jpn. J. Pharmacol. 52 (1990) 195-200
91. Tsuiki K., Yamamoto Y.L., and Diksic M. Effect of acute fluoxetine treatment on the brain serotonin synthesis as measured by the α-methyl-tryptophan autoradiographic method. J. Neurosci. 65 (1995) 250-256
92. van Riezen H., and Leonard B. Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats. Pharmacol. Ther. 47 (1990) 21-34
93. Vanier M., Tsuiki K., Grdisa M., Worsley K., and Diksic M. Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis. J. Neurochem. 64 (1995) 624-635
94. Vertes R.P., Fortin W.J., and Crane A.M. Projections of the median raphe nucleus in the rat. J. Comp. Neurol. 407 (1999) 555-582
95. Vertes R.P., and Kocsis B. Projections of the dorsal raphe nucleus to the brainstem: PHA-L analysis in the rat. J. Comp. Neurol. 340 (1994) 11-26
96. Watanabe A., Hasegawa S., Nishi K., Nguyen K.Q., and Diksic M. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain Res. Bull. 69 (2006) 101-108
97. Watanabe A., Tohyama Y., Nguyen K.Q., Hasegawa S., Debonnel G., and Diksic M. Regional brain serotonin synthesis is increased in the olfactory bulbectomy rat model of depression: an autoradiographic study. J. Neurochem. 85 (2003) 469-475
98. Yamane F., Tohyama Y., and Diksic M. Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study. Neurochem. Res. 24 (1999) 1611-1620
99. Zhou D., Grecksch G., Becker A., Franke C., and Pulz J. Serotonergic hyperinnervation of the frontal cortex in an animal model of depression, the bulbectomized rat. J. Neurosci. Res. 54 (1998) 109-116