DNA loaded carrier preferential extravasation from tumor blood vessel

International Journal of Pharmaceutics

Volumn 369, Issue 1-2, 2009, Pages 155-161

  Jiang, Ge ^a   Jiang, Yingzhi ^b   Shen, Yuanyuan ^c   Nam, Kweon Ho ^d   Lee, Donhaeng ^e   Gao, Zhonggao ^c,d  

^a DALIAN UNIVERSITY   (China)

^b YANBIAN UNIVERSITY   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d UNIVERSITY OF UTAH   (United States)

^e Inha University Hospital   (South Korea)

Author keywords

Cancer cells; DNA delivery; Dorsal skin fold window chamber; Polymethacrylic acid

Indexed keywords

DNA; DRUG CARRIER; POLYETHYLENEIMINE; POLYMETHACRYLIC ACID;

ARTICLE; CANCER CELL; CELL STRAIN HEPG2; CYTOTOXICITY; DRUG COATING; ERYTHROCYTE AGGREGATION; EXPERIMENTAL MOUSE; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; INCUBATION TIME; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SKINFOLD; TUMOR VASCULARIZATION;

ANIMALS; CELL LINE, TUMOR; DNA; ERYTHROCYTE AGGREGATION; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HUMANS; MICE; MICE, INBRED C57BL; NEOPLASMS; PARTICLE SIZE; POLYETHYLENEIMINE; POLYMETHACRYLIC ACIDS; SKIN WINDOW TECHNIQUE; TRANSFECTION;

EID: 60849125711     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.10.022     Document Type: Article

References (32)

1. Ahn C.H., Chae S.Y., Bae Y.H., and Kim S.W. Biodegradable poly(ethylenimine) for plasmid DNA delivery. J. Control. Release 80 (2002) 273-282
2. Bartlett D.W., Su H., Hildebrandt I.J., Weber W.A., and Davis M.E. Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 15549-15554
3. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., and Behr J.P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 7297-7301
4. Boussif O., Zanta M.A., and Behr J.P. Optimized galenics improve in-vitro gene-transfer with cationic molecules up to 1000-fold. Gene Ther. 3 (1996) 1074-1080
5. Campbell R.B. Tumor physiology and delivery of nanopharmaceuticals. Anticancer Agents Med. Chem. 6 (2006) 503-512
6. Chollet P., Favrot M.C., Hurbin A., and Coll J.L. Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J. Gene Med. 4 (2002) 84-91
7. Dewhirst M.W., Shan S., Cao Y., Moeller B., Yuan F., and Li C.Y. Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. Dis. Markers 18 (2002) 293-311
8. Gao Z., Fein H.D., and Rapoport N. Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound. J. Control. Release 102 (2005) 203-222
9. Gao Z., Fein H.D., and Rapoport N.Y. Ultrasound-triggered targeting of micellar-encapsulated drugs to ovarian carcinoma tumors in vivo. Mol. Pharm. 1 (2004) 317-330
10. Gao Z., Lukyanov A.N., Singhal A., and Torchilin V.P. Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Lett. 2 (2002) 979-982
11. Godbey W.T., Wu K.K., and Mikos A.G. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 5177-5181
12. Hobbs S.K., Monskey W.L., Yuan F., Roberts W.G., Griffith L., Torchilin V.P., and Jain R.K. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 4607-4612
13. Hunter A.C. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. Adv. Drug Deliv. Rev. 58 (2006) 1523-1531
14. Izumrudov V.A., Kharlampieva E., and Sukhishvili S.A. Multilayers of a globular protein and a weak polyacid: role of polyacid ionization in growth and decomposition in salt solutions. Biomacromolecules 6 (2005) 1782-1788
15. Jones R.A., Cheung C.Y., Black F.E., Zia J.K., Stayton P.S., Hoffman A.S., and Wilson M.R. Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles. Biochem. J. 372 (2003) 65-75
16. Kharlampieva E., and Sukhishvili S.A. Ionization and pH stability of multilayers formed by self-assembly of weak polyelectrolytes. Langmuir 19 (2003) 1235-1243
17. Lichtenbeld H.C., Yuan F., Michel C.C., and Jain R.K. Perfusion of single tumor microvessels: application to vascular permeability measurement. Microcirculation 3 (1996) 349-357
18. Midoux P., and Monsigny M. Efficient gene transfer by histidylated polylysine/pDNA complexes. Bioconjug. Chem. 10 (1999) 406-411
19. Monsky W.L., Fukumura D., Gohongi T., Ancukiewcz M., Weich H.A., Torchilin V.P., Yuan F., and Jain R.K. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res. 59 (1999) 4129-4135
20. Ormai S., and Palkovits M. Lymphocytosis induced by polymethacrylic acid. Dose-effect and toxicity. Blut 31 (1975) 239-246
21. Oupicky D., Ogris M., Howard K.A., Dash P.R., Ulbrich K.L., and Seymour W. Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol. Ther. 5 (2002) 463-472
22. Rolland A., Collet B., Verge R.L., and Toujas L. Blood clearance and organ distribution of intravenously administered polymethacrylic nanoparticles in mice. J. Pharm. Sci. 78 (1989) 481-484
23. Shan S., Flowers C., Peltz C.D., Sweet H., Maurer N., Kwon E.J., Krol A., Yuan F., and Dewhirst M.W. Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. Cancer Chemother. Pharmacol. 58 (2006) 245-255
24. Sukhishvili S., and Granick S. Layered, erasable polymer multilayers formed by hydrogen-bonded self-assembly. Macromolecules 35 (2002) 301-310
25. Tozer G.M., Prise V.E., Wilson J., Cemazar M., Shan S., Dewhirst M.W., Barber P.R., Vojnovic B., and Chaplin D.J. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res. 61 (2001) 6413-6422
26. Trubetskoy V.S., Wong S.C., Subbotin V., Budker V.G., Loomis A., Hagstrom J.E., and Wolff J.A. Recharging cationic DNA complexes with highly charged polyanions for in vitro and in vivo gene delivery. Gene Ther. 10 (2003) 261-271
27. Tseng W.C., and Jong C.M. Improved stability of polycationic vector by dextran-grafted branched polyethylenimine. Biomacromolecules 4 (2003) 1277-1284
28. Wu N.Z., Klitzman B., Rosner G., Needham D., and Dewhirst M.W. Measurement of material extravasation in microvascular networks using fluorescence video-microscopy. Microvasc. Res. 46 (1993) 231-253
29. Wu N.Z., Braun R.D., Gaber M.H., Lin G.M., Ong E.T., Shan S., Papahadjopoulos D., and Dewhirst M.W. Simultaneous measurement of liposome extravasation and content release in tumors. Microcirculation 4 (1997) 83-101
30. Xie A.F., and Granick S. Local electrostatics within a polyelectrolyte multilayer with embedded weak polyelectrolyte. Macromolecules 35 (2002) 1805-1813
31. Yang S.Y., Mendelsohn J.D., and Rubner M.F. New class of ultrathin, highly cell-adhesion-resistant polyelectrolyte multilayers with micropatterning capabilities. Biomacromolecules 4 (2003) 987-994
32. Yuan F., Salehi H.A., Boucher Y., Vasthare U.S., Tuma R.F., and Jain R.K. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res. 54 (1994) 4564-4568