Neurobehavioral effects in relation to endocrine alterations caused by exposure to brominated flame retardants in ratscomparison to polychlorinated biphenyls

Human and Ecological Risk Assessment

Volumn 15, Issue 1, 2009, Pages 76-86

  Lilienthal, Hellmuth ^a   Van Der Ven, Leo ^b   Hack, Alfons ^a   Roth Härer, Astrid ^a   Piersma, Aldert ^b   Vos, Joseph ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Behavior; Brainstem auditory evoked potentials; Brominated flame retardants; Polychlorinated biphenyls

Indexed keywords

RATTUS;

EID: 60849118122     PISSN: 10807039     EISSN: 15497860     Source Type: Journal    
DOI: 10.1080/10807030802615253     Document Type: Article

References (53)

1. Avent KM, Devoss JJ, Gillam EM, et al., 2006. Cytochrome p450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chem Res Toxicol 19:914-20
2. Birnbaum LS and Staskal DF. 2004. Brominated flame retardants: Cause for concern? Environ Health Persp 112:9-17
3. Bonefeld-Jorgensen EC, Andersen HR, and Rasmussen TJ. 2001. Effects of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology 158:141-53
4. Builee TL and Hatherill JR. 2004. The role of polyhalogenated aromatic hydrocarbons on thyroid hormone disruption and cognitive function: A review. Drug Chem Toxicol 27:405-24
5. Crofton KM, Ding D-L, Padich R, et al., 2000. Hearing loss following exposure during development to polychlorinated biphenyls: A cochlear site of action. Hearing Res 144:196-204
6. Darnerud PO. 2003. Toxic effects of brominated flame retardants in man and wildlife. Environ Int 29:841-53
7. Darnerud PO, Lundgren M, Lilienthal H, et al., 2006. Detoxification of BDE99 is changed by a common viral infection in the mouse. Organohalogen Compounds 68:1971-1974
8. Eriksson P, Jakobsson E, Fredriksson A, et al., 2001. Brominated flame retardants: A novel class of developmental neurotoxicants in our environment? Environ Health Perspect 109: 903-8
9. Eriksson J, Green N, Marsh G, et al., 2004. Photochemical decomposition of 15 polybrominated diphenyl ether congeners in methanol/water. Environ Sci Technol 38:3119-25
10. Eriksson P, Fischer C, Wallin M, et al., 2006. Impaired behavior, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD). Environ Toxicol Pharmacol 21:317-22
11. Fonnum F, Mariussen E, Reistad T, et al., 2006. Molecular mechanism involved in the toxic effects of polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs). J Toxicol Environ Health, Part A 69:21-35
12. Germer S, Piersma AH, van der Ven L, et al., 2006. Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P. 450 levels in rats. Toxicology 218:229-36
13. Goldey ES and Crofton KM. 1998. Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats. Toxicol Sci 45:94-105
14. Goldey ES, Kehn LS, Lau C, et al., 1995. Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol Appl Pharmacol 135:77-88
15. Haddow JE, Palomaki GE, and Allan WC. 1999. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549-55
16. Hallgren S and Darnerud PO. 2002. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-Testing interactions and mechanisms for thyroid hormone effects. Toxicology 177:227-43
17. Hairy J, Lilienthal H, Sarasin A, et al., 1999. Developmental exposure of rats to a reconstituted PCB mixture or Aroclorl 254: Effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior. Toxicol Appl Pharmacol 158:231-43
18. Kaya H, Hany J, Fastabend A, et al., 2002. Effects of maternal exposure to a reconstituted mixture of polychlorinated biphenyls on sex-dependent behaviors and steroid hormone concentrations in rats: Dose-response relationship. Toxicol Appl Pharmacol 178:71-81
19. Kester MH, Martinez de Mendez R, and Obregon MJ. 2004. Iodothyronine levels in developing human brain: Major regulatory roles of iodothyronine deiodinases in different brain areas. J Clin Endocrinol Metabol 89:3114-6
20. Knipper M, Zinn C, Maier H, et al., 2000. Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems. J Neurophysiol 83:3101-12
21. Kretschmer XC and Baldwin WS. 2005. CAR and PXR: Xenosensors of endocrine disrupters? Chem Biol Interact 155:111-28
22. Lechan RM and Fekete C. 2005. Role of thyroid hormone deiodination in the hypothalamus. Thyroid 15:883-97
23. Lephart ED. 1996. A review of brain aromatase cytochrome P. 450. Brain Res Rev 22:1-26
24. Lichtensteiger W, Faass O, Ceccatelli R, et al., 2004. Developmental exposure to PBDE99 and PCB affects estrogen sensitivity of target genes in rat brain regions and female sexual behavior. Organohalogen Compounds 66:3965-9
25. Lilienthal H, Weinand-Härer A, Winterhoff H, et al., 1997. Effects of maternal exposure to 3,3'4,4'-tetrachlorobisphenyl or propylthiouracil in rats trained to discriminate apomorphine from saline. Toxicol Appl Pharmacol 146:162-9
26. 3 in rat dams and offspring after exposure to a reconstituted PCB mixture. Toxicol Sci 57:292-301
27. Lilienthal H, Hack A, Roth-Härer A, et al., 2006. Effects of developmental exposure to 2,2',4,4',5-pentabrominateddiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats. Environ Health Persp 114:194-201
28. Lilienthal H, van der Ven LTM, Piersma Alt et al., 2008. Effects of the brominated flame retardant hexabromocyclododecane (HBCD) on dopamine-dependent behavior and brainstem auditory evoked potentials in a one-generation reproduction study in wistar rats. Toxicol Lett (in press)
29. McEwen BS. 2001. Estrogens effects on the brain: Multiple sites and molecular mechanisms. J Appl Physiol 91:2785-801
30. McGrath JJ, Feron F, Burne THJ, et al., 2004. Vitamin D3-Implications for brain development. J Steroid Biochem Mol Biol 89-90:557-60
31. Meerts IATM, van Zanden JJ, Luijks EAC, et al., 2000. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci 56:95-104.
32. Meerts IATM, Hoving S, van den Berg JHJ, et al., 2004. Developmental exposure to 4-hydroxy-2,3,3',4'5-pentachlorobiphenyl (4-OH-CB107): Long-term effects on brain development, behavior, and brain stem auditory evoked potentials in rats. Toxicol Sci 82:207-18.
33. Morreale de Escobar G, Obregon MJ, and Escobar del Rey F. 2004. Role of thyroid hormone during early brain development. Eur J Endocrinol 151:U25-37
34. 2-like receptor function is converted from excitatory to inhibitory by thyroxine in the developmental hippocampus. J Neuroendocrinol 17:836-45
35. Pacyniak EK, Cheng X, Cunningham ML, et al., 2007. The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicol Sci 97:94-102
36. Pop VJ, Kuijpens JL, van Baar AL, et al., 1999. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol 50:149-55
37. Porterfield SP. 2000. Thyroid dysfunction and environmental chemicals-Potential impact on brain development. Environ Health Persp 108(suppl) 3:433-8
38. Sanders JM, Burka LT, Smith CS, et al., 2005. Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. Toxicol Sci 88:127-33
39. Schriks M, Vrabie CM, Gutlev A, et al., 2006. T-screen to quantify functional potentiating, antagonistic and thyroid hormone-like activities of polyhalogenated aromatic hydrocarbons (PHAHs). Toxicol in Vitro 20:490-8
40. Seegal RF. 1996. Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit Rev Toxicol 26:709-37
41. Shibusawa N, Hashimoto K, Nikrodhanond AA, et al., 2003. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest 112:588-97
42. Slob W. 2002. Dose-response modeling of continuous endpoints. Toxicol Sci 66:298-312
43. Smith JW, Evans AT, Costall B, et al., 2002. Thyroid hormones, brain function and cognition: A brief review. Neurosci Biobehav Rev 26:45-60
44. Staple ton HM, Brazil B, Holbrook RD, et al., 2006. In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) byjuvenile rainbow trout and common carp. Environ Sci Technol 40:4653-8
45. Stoker TE, Laws SC, Crofton KM, et al., 2004. Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols. Toxicol Sci 78:144-55
46. Stoker TE, Cooper RL, Lambright CS, et al., 2005. In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture. Toxicol Appl Pharmacol 207:78-88
47. Todd BJ, Schwarz JM, and McCarthy MM. 2005. Prostaglandin-E2: A point of divergence in estradiol-mediated sexual differentiation. Horm Behav 48:512-21
48. Valenstein ES, Kakolewski JW, and Cox VC. 1967. Sex differences in taste preference for glucose and saccharin solutions. Science 156:942-3
49. Van der Ven LTM, Verhoef A, van de Kuil T, et al., 2006. A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats. Toxicol Sci 94:281-92
50. Van der Ven LTM, van der Keul T, Verhoef A, et al., 2008. Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study. Toxicology 245:76-89
51. Vinggaard AM, Hass LI, Dalgaard M, et al., 2006. Prochloraz: An imidazole fungicide with multiple mechanisms of action. Int J Androl 29:186-92
52. Weinand-Härer A, Lilienthal H, Bucholski KA, et al., 1997. Behavioral effects of maternal exposure to an ortho-chlorinated or a coplanar PCB congener in rats. Environ Toxicol Pharmacol 3:97-103
53. Zhou T, Taylor MM, De Vito MJ, et al., 2002. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol Sci 66:05-16