Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo

Journal of Clinical Investigation

Volumn 112, Issue 4, 2003, Pages 588-597

  Shibusawa, Nobuyuki ^a,e   Hashimoto, Koshi ^a,e   Nikrodhanond, Amisra A ^a   Liberman, M Charles ^b   Applebury, Meredithe L ^b   Liao, Xiao Hui ^c   Robbins, Janet Liao T ^b   Refetoff, Samuel ^a,c   Cohen, Ronald N ^a   Wondisford, Fredric E ^a,d  

^a UNIVERSITY OF CHICAGO   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; THYROID HORMONE; THYROID HORMONE RECEPTOR; LIGAND;

ANIMAL EXPERIMENT; ARTICLE; COCHLEA; DNA BINDING; HAIR CELL; HISTOPATHOLOGY; HORMONE ACTION; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; KNOCKOUT MOUSE; LIGAND BINDING; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RETINA DEVELOPMENT; SIGNAL TRANSDUCTION; ALLELE; AMINO ACID SEQUENCE; ANIMAL; BLOOD; C57BL MOUSE; FLUORESCENCE MICROSCOPY; GENETIC RECOMBINATION; GENETICS; HOMOZYGOTE; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; PROTO ONCOGENE; TIME; TRANSGENIC MOUSE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA; GENES, ERBA; HOMOZYGOTE; IMMUNOHISTOCHEMISTRY; LIGANDS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINATION, GENETIC; THYROID HORMONES; TIME FACTORS;

EID: 85047692403     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI18377     Document Type: Article

References (35)

1. Brent, G.A. 1994. The molecular basis of thyroid hormone action. N. Engl. J. Med. 331:847-853.
2. Oppenheimer, J.H., and Schwartz, H.L. 1997. Molecular basis of thyroid hormone-dependent brain development. Endocr. Rev. 18:462-475.
3. Koibuchi, N., and Chin, W.W. 2000. Thyroid hormone action and brain development. Trends Endocrinol. Metab. 11:123-128.
4. Cohen, R.C., Weintraub, B.D., and Wondisford, F.E. 2000. Chemistry and biosynthesis of thyrotropin. In Werner and Ingbar's The thyroid: a fundamental and clinical text. 8th edition. L.E. Braverman, and R.D. Utiger, editors. Williams & Wilkins. Baltimore, Maryland, USA. 202-218.
5. Forrest, D., Erway, L.C., Ng, L., Altschulet, R., and Curtan, T. 1996. Thyroid hormone receptor beta is essential for development of auditory function. Nat. Genet. 13:354-357.
6. Abel, E.D., et al. 1999. Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J. Clin. Invest. 104:291-300.
7. Ng, L., et al. 2001. A thyroid hormone receptor that is required for the development of green cone photoreceptors. Nat. Genet. 27:94-98.
8. Gauthier, K., et al. 1999. Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J. 18:623-631.
9. Weiss, R.E., Forrest, D., Pohlenz, J., Cua, K., Curran, T., and Refetoff, S. 1997. Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice. Endocrinology. 138:3624-3629.
10. Abel, E.D., Ahima, R., Boer, M.-E., Elmquist, J.K., and Wondisford, F.E. 2001. Critical role for thyroid hormone receptor β-2 in the regulation of TRH neurons in the paraventricular hypothalamus. J. Clin. Invest. 107:1017-1023.
11. Bodenner, D.L., Mroczynski, M.A., Weintraub, B.D., Radovick, S., and Wondisford, F.E. 1991. A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene. J. Biol. Chem. 266:21666-21673.
12. Naar, A.M., et al. 1991. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell. 65:1267-1279.
13. Hollenberg, A.N., Monden, T., Flynn, T.R., Boers, M.E., Cohen, O., and Wondisford, F.E. 1995. The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements. Mol. Endocrinol. 9:540-550.
14. Sasaki, S., et al. 1999. Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene. EMBO J. 18:5389-5398.
15. Tagami, T., Madison, L.D., Nagaya, T., and Jameson, J.L. 1997. Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. Mol. Cell Biol. 17:2642-2648.
16. Reichardt, H.M., et al. 1998. DNA binding of the glucocorticoid receptor is not essential for survival. Cell. 93:531-541.
17. Shibusawa, N., Hollenberg, A.N., and Wondisford, F.E. 2003. Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. J. Biol. Chem. 278:732-738.
18. Bunting, M., Bernstein, K.E., Greer, J.M., Capecchi, M.R., and Thomas, K.R. 1999. Targeting genes for self-excision in the germ line. Genes Dev. 13:1524-1528.
19. Williams, G.R. 2000. Cloning and characterization of two novel thyroid hormone receptor beta isoforms. Mol. Cell Biol. 20:8329-8342.
20. Sjoberg, M., Vennstrom, B., and Forrest, D. 1992. Thyroid hormone receptors in chick retinal development: differential expression of mRNAs for alpha and N-terminal variant beta receptors. Development. 114:39-47.
21. Bradley, D.J., Towle, H.C., and Young, W.S., III. 1994. Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo. Proc. Natl. Acad. Sci. U. S. A. 91:439-443.
22. Applebury, M.L., et al. 2000. The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning. Neuron. 27:513-523.
23. Dallos, P. 1992. The active cochlea. J. Neurosci. 12:4575-4585.
24. Brown, M.C., Nuttall, A.L., and Masta, R.I. 1983. Intracellular recordings from cochlear inner hair cells: effects of stimulation of the crossed olivocochlear efferents. Science. 222:69-72.
25. Liberman, M.C., et al. 2002. Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature. 419:300-304.
26. Lazar, M.A. 1993. Thyroid hormone receptors: multiple forms, multiple possibilities. Endocr. Rev. 14:184-193.
27. Wondisford, F.E., Steinfelder, H.J., Nations, M., and Radovick, S. 1993. AP-1 antagonizes thyroid hormone receptor action on the thyrotropin b-subunit gene. J. Biol. Chem. 268:2749-2754.
28. Zhang, X.K., Willis, K.N., Husmann, M., Hermann, T., and Pfahl, M. 1991. Novel pathways for thyroid hormone receptor action through interaction with jun and fos oncogene activities. Mol. Cell Biol. 11:6016-6025.
29. Refetoff, S., Weiss, R.E., and Usala, S.J. 1993. The syndromes of resistance to thyroid hormone. Endocr. Rev. 14:348-399.
30. Yanagi, Y., Takezawa, S., and Kato, S. 2002. Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta 2 and CRX in one photoreceptor development. Invest. Ophthalmol. Vis. Sci. 43:3489-3494.
31. Izumo, S., Nadal-Ginard, B., and Mahdavi, V. 1986. All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Science. 231:597-600.
32. Rusch, A., Erway, L.C., Oliver, D., Vennstrom, B., and Forrest, D. 1998. Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing. Proc. Natl. Acad. Sci. U. S. A. 95:15758-15762.
33. Rusch, A., et al. 2001. Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors. J. Neurosci. 21:9792-9800.
34. Deol, M.S. 1976. The role of thyroxine in the differentiation of the organ of Corti. Acta. Otolaryngol. 81:429-435.
35. Claret, F.-X., Antakly, T., Karin, M., and Saarcioglu, F. 1996. A shift in the ligand responsiveness of thyroid hormone receptor α induced by heterodimerization with retinoid X receptor α. Mol. Cell Biol. 16:219-227.