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Peroxide oligomers are potentially hazardous and explosive: Zabicky, J. The Chemistry of Peroxides; Rappoport, Z., Ed.; Wiley: Chichester, UK, 2006; 2, Chapter 7, pp 597-774. No difficulties were encountered in the handling or purification of these compounds on small scale. Details are provided in the Supporting Information.
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Peroxide oligomers are potentially hazardous and explosive: Zabicky, J. The Chemistry of Peroxides; Rappoport, Z., Ed.; Wiley: Chichester, UK, 2006; Vol. 2, Chapter 7, pp 597-774. No difficulties were encountered in the handling or purification of these compounds on small scale. Details are provided in the Supporting Information.
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Treatment of carbonyl compounds with acidic hydrogen peroxide or its derivatives can yield peroxide oligomers and Baeyer-Villiger oxidation products: Renz, M.; Meunier, B. Eur. J. Org. Chem. 1999, 737-750.
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Details are provided in the Supporting Information
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Details are provided in the Supporting Information.
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62149150722
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Reaction conditions have not been optimized
-
Reaction conditions have not been optimized.
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62149109407
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In other experiments, 1,2-disubstituted alkenes without the phenyl group did not form the desired 1,2,4-trioxanes. It appears that the additional stability of the proposed carbocationic intermediate 33 (Table 3) conferred by the phenyl substituent allowed the product to form from a disubstituted alkene
-
In other experiments, 1,2-disubstituted alkenes without the phenyl group did not form the desired 1,2,4-trioxanes. It appears that the additional stability of the proposed carbocationic intermediate 33 (Table 3) conferred by the phenyl substituent allowed the product to form from a disubstituted alkene.
-
-
-
-
50
-
-
62149119650
-
-
Loss of stereochemistry was also observed in trisubstituted alkene substrates (Table 2, entry 6).
-
Loss of stereochemistry was also observed in trisubstituted alkene substrates (Table 2, entry 6).
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