Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate: Report of a case

Surgery Today

Volumn 38, Issue 1, 2008, Pages 65-67

  Utsunomiya, Tohru ^a   Okamoto, Masahiro ^a   Yano, Shuya ^a   Kameyama, Toshihumi ^a   Matsuyama, Ayumi ^a   Kuma, Sosei ^a   Yamamoto, Manabu ^a   Fujiwara, Megumu ^a   Ishida, Teruyoshi ^a  

^a ATOMIC BOMB SURVIVORS HOSPITAL   (Japan)

Author keywords

Gastrointestinal stromal tumor; Imatinib resistance; Liver metastasis; Recurrence; Secondary mutation

Indexed keywords

IMATINIB; STEM CELL FACTOR RECEPTOR;

AGED; AMINO ACID SUBSTITUTION; ARTICLE; BONE MARROW SUPPRESSION; CASE REPORT; DRUG WITHDRAWAL; EXON; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL STROMAL TUMOR; GENE DELETION; HUMAN; LAPAROTOMY; LIVER METASTASIS; LONG TERM CARE; MALE; MUTATIONAL ANALYSIS; PANCREAS RESECTION; PANCREATICOSPLENECTOMY; PANCYTOPENIA; PARTIAL GASTRECTOMY; PARTIAL HEPATECTOMY; SURGICAL TECHNIQUE; TREATMENT DURATION; TUMOR RECURRENCE;

AGED; ANTINEOPLASTIC AGENTS; DNA, NEOPLASM; EXONS; FOLLOW-UP STUDIES; GASTROINTESTINAL STROMAL TUMORS; HUMANS; MALE; NEOPLASM RECURRENCE, LOCAL; PIPERAZINES; POINT MUTATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 37349051430     PISSN: 09411291     EISSN: 14362813     Source Type: Journal    
DOI: 10.1007/s00595-007-3559-8     Document Type: Article

References (10)

1. GD Demetri M von Mehren CD Blanke AD Van den Abbeele B Eisenberg PJ Roberts 2002 Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors N Engl J Med 347 472 80
2. T Wakai T Kanda S Hirota A Ohashi Y Shirai K Hatakeyama 2004 Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumor is associated with a second KIT mutation Br J Cancer 90 2059 61
3. LL Chen JC Trent EF Wu GN Fuller L Ramdas W Zhang 2004 A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors Cancer Res 64 5913 9
4. E Tamborini L Bonadiman A Greco V Albertini T Negri A Gronchi 2004 A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient Gastroenterology 127 294 9
5. MC Heinrich CL Corless CD Blanke GD Demetri H Joensuu PJ Roberts 2006 Molecular correlates of imatinib resistance in gastrointestinal stromal tumors J Clin Oncol 24 4764 74
6. F Bertucci A Goncalves G Monges A Madroszyk J Guiramand V Moutardier 2006 Acquired resistance to imatinib and secondary KIT exon 13 mutation in gastrointestinal stromal tumor Oncol Rep 16 97 101
7. E Tamborini S Pricl T Negri MS Lagonigro F Miselli A Greco 2006 Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients Oncogene 25 6140 6
8. JY Blay S Bonvalot P Casali H Choi M Debiec-Richter AP Dei Tos 2005 Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO Ann Oncol 16 566 78
9. C Sakakura A Hagiwara K Soga K Miyagawa S Nakashima T Yoshikawa 2006 Long-term survival of a case with multiple liver metastases from duodenal gastrointestinal stromal tumor drastically reduced by the treatment with imatinib and hepatectomy World J Gastroenterol 12 2793 7
10. H Prenen J Cools N Mentens C Folens R Sciot P Schoffski 2006 Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate Clin Cancer Res 12 2622 7