Deleting the accessory subunit KChIP2 results in loss of Ito,f and increased IK,slow that maintains normal action potential configuration

Heart Rhythm

Volumn 6, Issue 3, 2009, Pages 370-377

  Thomsen, Morten B ^b   Sosunov, Eugene A ^a   Anyukhovsky, Evgeny P ^a   Özgen, Nazira ^a   Boyden, Penelope A ^a   Rosen, Michael R ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Action potentials; Animal models; Electrophysiology; Potassium currents; Repolarization

Indexed keywords

4 AMINOPYRIDINE; MEMBRANE PROTEIN; POTASSIUM CHANNEL KV1.5; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL INTERACTING PROTEIN 2;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART MUSCLE; HEART REPOLARIZATION; MALE; MICROELECTRODE; MOUSE; MUSCLE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; UPREGULATION; WILD TYPE;

ACTION POTENTIALS; ANIMALS; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEART VENTRICLES; KV CHANNEL-INTERACTING PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROELECTRODES; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 60749109820     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2008.11.023     Document Type: Article

References (37)

1. Kaab S., Dixon J., Duc J., et al. Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98 (1998) 1383-1393
2. Lue W.M., and Boyden P.A. Abnormal electrical properties of myocytes from chronically infarcted canine heart. Alterations in Vmax and the transient outward current. Circulation 85 (1992) 1175-1188
3. Huang B., Qin D., and El-Sherif N. Spatial alterations of Kv channels expression and K(+) currents in post-MI remodeled rat heart. Cardiovasc Res 52 (2001) 246-254
4. Tomaselli G.F., and Marban E. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42 (1999) 270-283
5. Xu H., Guo W., and Nerbonne J.M. Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes. J Gen Physiol 113 (1999) 661-678
6. Brunet S., Aimond F., Li H., et al. Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles. J Physiol 559 Pt 1 (2004) 103-120
7. Guo W., Xu H., London B., et al. Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. J Physiol 521 Pt 3 (1999) 587-599
8. London B., Guo W., Pan X., et al. Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced QT prolongation. Circ Res 88 (2001) 940-946
9. Xu H., Barry D.M., Li H., et al. Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit. Circ Res 85 (1999) 623-633
10. Marionneau C., Aimond F., Brunet S., et al. PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy. J Mol Cell Cardiol 44 (2008) 1002-1015
11. Niwa N., Wang W., Sha Q., et al. Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles. J Mol Cell Cardiol 44 (2008) 95-104
12. Nerbonne J.M., and Kass R.S. Molecular physiology of cardiac repolarization. Physiol Rev 85 (2005) 1205-1253
13. Wang H., Yan Y., Liu Q., et al. Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat Neurosci 10 (2007) 32-39
14. Callsen B., Isbrandt D., Sauter K., et al. Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected]. J Physiol 568 Pt 2 (2005) 397-412
15. An W.F., Bowlby M.R., Betty M., et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403 (2000) 553-556
16. Deschenes I., DiSilvestre D., Juang G.J., et al. Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?. Circulation 106 (2002) 423-429
17. Rosati B., Pan Z., Lypen S., et al. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533 Pt 1 (2001) 119-125
18. Li H., Guo W., Mellor R.L., et al. KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+) channels. J Mol Cell Cardiol 39 (2005) 121-132
19. Nabauer M., Beuckelmann D.J., and Erdmann E. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 73 (1993) 386-394
20. Beuckelmann D.J., Nabauer M., and Erdmann E. Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 73 (1993) 379-385
21. Radicke S., Cotella D., Graf E.M., et al. Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res 71 (2006) 695-703
22. Barry D.M., Xu H., Schuessler R.B., et al. Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circ Res 83 (1998) 560-567
23. Wickenden A.D., Lee P., Sah R., et al. Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart. Circ Res 85 (1999) 1067-1076
24. Guo W., Jung W.E., Marionneau C., et al. Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circ Res 97 (2005) 1342-1350
25. Kuo H.C., Cheng C.F., Clark R.B., et al. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell 107 (2001) 801-813
26. Sanguinetti M.C., Johnson J.H., Hammerland L.G., et al. Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol 51 (1997) 491-498
27. Marionneau C., Brunet S., Flagg T.P., et al. Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy. Circ Res 102 (2008) 1406-1415
28. Roden D.M. Taking the "idio" out of "idiosyncratic": predicting torsades de pointes. Pacing Clin Electrophysiol 21 (1998) 1029-1034
29. Thomsen M.B., Matz J., Volders P.G., et al. Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias. Pharmacol Ther 112 (2006) 150-170
30. Kaab S., Hinterseer M., Nabauer M., et al. Sotalol testing unmasks altered repolarization in patients with suspected acquired long-QT-syndrome-a case-control pilot study using I.V. sotalol. Eur Heart J 24 (2003) 649-657
31. Vincent G.M., Timothy K.W., Leppert M., et al. The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome. N Engl J Med 327 (1992) 846-852
32. Roden D.M. Drug-induced prolongation of the QT interval. N Engl J Med 350 (2004) 1013-1022
33. Rosenbaum M.B., Blanco H.H., Elizari M.V., et al. Electrotonic modulation of the T wave and cardiac memory. Am J Cardiol 50 (1982) 213-222
34. Patberg K.W., Obreztchikova M.N., Giardina S.F., et al. The cAMP response element binding protein modulates expression of the transient outward current: implications for cardiac memory. Cardiovasc Res 68 (2005) 259-267
35. Yu H., McKinnon D., Dixon J.E., et al. Transient outward current, Ito1, is altered in cardiac memory. Circulation 99 (1999) 1898-1905
36. Plotnikov A.N., Shvilkin A., Xiong W., et al. Interactions between antiarrhythmic drugs and cardiac memory. Cardiovasc Res 50 (2001) 335-344
37. Fiset C., Clark R.B., Larsen T.S., et al. A rapidly activating sustained K+ current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. J Physiol 504 Pt 3 (1997) 557-563