Suppression of parathyroid hormone production in vitro and in vivo by RNA interference

Kidney International

Volumn 75, Issue 5, 2009, Pages 490-498

  Kanai, Genta ^a   Kakuta, Takatoshi ^a   Sawada, Kaichiro ^a   Yokoyama, Tun A ^a   Tanaka, Reika ^a   Saito, Akira ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hydrodynamic delivery; Parathyroid glands; Parathyroid hormone; RNA interference; Secondary hyperparathyroidism

Indexed keywords

PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HYPERPARATHYROIDISM; IN VITRO STUDY; IN VIVO STUDY; MONOLAYER CULTURE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PARATHYROID CELL; PRIORITY JOURNAL; RNA INTERFERENCE;

EID: 60749100024     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.568     Document Type: Article

References (34)

1. Silver J, Levi R. Cellular and molecular mechanisms of secondary hyperparathyroidism. Clin Nephrol 2005; 63: 119-126.
2. Raggi P, Boulay A, Chasan-Taber S et al. Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 2002; 39: 695-701.
3. Goodman WG, Goldin J, Kuizon BD et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342: 1478-1483.
4. Chertow GM, Burke SK, Raggi P. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 2002; 62: 245-252.
5. 3 in the parathyroid glands of patients with renal failure. N Engl J Med 1987; 316: 1573-1577.
6. Merke J, Hugel U, Zlotowski A et al. Diminished parathyroid 1,25(OH)2D3 receptors in experimental uremia. Kidney Int 1987; 32: 350-353.
7. Brown AJ, Dusso A, Lopez-Hilker S et al. 1,25 (OH)2D receptors are decreased in parathyroid glands from chronically uremic dogs. Kidney Int 1989; 35: 19-23.
8. Shvil Y, Naveh-Mary T, Barach P et al. Regulation of parathyroid cell gene expression in experimental uremia. J Am Soc Nephrol 1990; 1: 99-104.
9. Fukagawa M, Kitaoka M, Kurokawa K. Resistance to vitamin D in chronic renal failure. Kidney Int 1997; 52(Suppl 62): S60-S64.
10. Patel SR, Ke H, Vanholder R et al. Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxins. J Clin Invest 1995; 96: 50-59.
11. Sawaya P, Koszewski NJ, Qi Q et al. Secondary hyperparathyroidism and vitamin D receptor binding to vitamin D responsive elements in rats with incipient renal failure. J Am Soc Nephrol 1997; 8: 271-278.
12. Perret C, Colnot S, Romagnolo B et al. Control of nuclear transcription of vitamin D. Curr Opin Nephrol Hypertens 1997; 6: 314-320.
13. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996; 81: 1598-1606.
14. Schmitt CP, Huber D, Mehls O et al. Altered instantaneous and calcium-modulated oscillatory PTH secretion patterns in patients with secondary hyperparathyroidism. J Am Soc Nephrol 1998; 9: 1832-1844.
15. Nemeth EF, Steffey ME, Hammerland LG et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci USA 1998; 95: 4040-4045.
16. Dykxhoorn DM, Lieberman J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu Rev Med 2005; 56: 401-423.
17. Elbashir SM, Harborth J, Lendeckel W et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture. Nature 2001; 411: 494-498.
18. McCaffrey AP, Meuse L, Pham TT et al. RNA interference in adult mice. Nature 2002; 418: 38-39.
19. 2+-sensing receptor expression in functionally active, long-term human parathyroid cell cultures. J Bone Miner Res 1998; 13: 354-362.
20. Liu W, Ridefelt P, Akerstrom G et al. Differentiation of human parathyroid cells in culture. J Endocrinol 2001; 168: 417-425.
21. Tsuji K, Sawada T, Masuda A et al. Culture of human parathyroid cells. Organ Biol 1999; 6: 73-80.
22. Gilbert SF, Migeon BR. D-valine as a selective agent for normal human and rodent epithelial cells in culture. Cell 1975; 5: 11-17.
23. Ridgeway RD, Hamilton JW, MacGregor RR. Characteristics of bovine parathyroid cell organoids in culture. In Vitro Cell Dev Biol 1986; 22: 91-99.
24. Ritter CS, Slatopolsky E, Santoro S et al. Parathyroid cells cultured in collagen matrix retain calcium responsiveness: importance of three-dimensional tissue architecture. J Bone Miner Res 2004; 19: 491-498.
25. Brown AJ, Zhong M, Ritter C et al. Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with decreased calcium receptor expression. Biochem Biophys Res Commun 1995; 212: 861-867.
26. Mithal A, Kifor O, Kifor I et al. The reduced responsiveness of cultured bovine parathyroid cells to extracellular Ca2+ is associated with marked reduction in the expression of extracellular Ca2+-sensing receptor messenger ribonucleic acid and protein. Endocrinology 1995; 136: 3087-3092.
27. LeBoff MS, Rennke HG, Brown EM. Abnormal regulation of parathyroid cell secretion and proliferation in primary cultures of bovine parathyroid cells. Endocrinology 1983; 113: 277-284.
28. LeBoff MS, Shoback D, Brown EM et al. Regulation of parathyroid hormone release and cytosolic calcium by extracellular calcium in dispersed and cultured bovine and pathologic human parathyroid cells. J Clin Invest 1985; 75: 49-57.
29. Kremer R, Bolivar I, Goltzman D et al. Influence of calcium and 1,25-dihydroxycholecalciferol on proliferation and proto-oncogene expression in primary cultures of bovine parathyroid cells. Endocrinology 1989; 125: 935-941.
30. Nygren P, Larsson R, Johansson H et al. Inhibition of cell growth retains differentiated function of bovine parathyroid cells in monolayer culture. J Bone Miner Res 1988; 4: 123-132.
31. Sun F, Maerchlein P, Fitzpatrich LA. Paracrine interactions among parathyroid cells: effect of cell density on cell secretion. J Bone Miner Res 1994; 9: 971-976.
32. Yalcindag C, Silver J, Naveh-Many T. Mechanism of increased parathyroid hormone mRNA in experimental uremia: roles of protein RNA binding and RNA degradation. J Am Soc Nephrol 1999; 10: 2562-2568.
33. Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injection of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-1737.
34. Lorenz C, Hadwiger P, John M et al. Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells. Bioorg Med Chem Lett 2004; 14: 4975-4977.