Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells

Journal of Immunology

Volumn 177, Issue 10, 2006, Pages 7257-7265

  Lemaire, Irma ^a   Falzoni, Simonetta ^b   Leduc, Natacha ^a   Zhang, Bin ^a   Pellegatti, Patrizia ^b   Adinolfi, Elena ^b   Chiozzi, Paola ^b   Di Virgilio, Francesco ^b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BRILLIANT BLUE; BRILLIANT BLUE G; OXIDIZED ADENOSINE TRIPHOSPHATE; PURINE P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; UNCLASSIFIED DRUG; 2',3' DIALDEHYDE ATP; 2',3'-DIALDEHYDE ATP; DRUG DERIVATIVE; GROWTH INHIBITOR; POLYMYXIN B; PURINE P2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL FUSION; CELL STIMULATION; CELL STRAIN HEK293; CHRONIC INFLAMMATION; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; GENETIC TRANSFECTION; GIANT CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RAT; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; DRUG SYNERGISM; GIANT CELLS; GROWTH INHIBITORS; HUMANS; MACROPHAGES, ALVEOLAR; MALE; POLYMYXIN B; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; TRANSFECTION;

EID: 33750842904     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.10.7257     Document Type: Article

References (48)

1. Adams, D. O. 1976. The granulomatous inflammatory response: a review. Am. J. Pathol. 84: 164-191.
2. Chambers, T. J. 1978. Multinucleated giant cells. J. Pathol. 126: 125-148.
3. Anderson, J. M. 2000. Multinucleated giant cells. Curr. Opin. Hematol. 7: 40-47.
4. Burger, E. H., J. W. Van der Meer, J. S. Van de Gevel, J. C. Gribnau, G. W. Thesingh, and R. Van Furth. 1982. In vitro formation of osteoclasts from long term cultures of bone marrow mononuclear phagocytes. J. Exp. Med. 156: 1604-1614.
5. Udagawa, N., N. Takahashi, T. Akatsu, H. Tanaka, T. Sasaki, T. Nishihara, T. Koga, T. J. Martin, and T. Suda. 1990. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under suitable microenvironment prepared by bone marrow-derived stromal cells. Proc. Natl Acad. Sci. USA 87: 7260-7264.
6. Itonaga, I., A. Sabokbar, D. W. Murray, and N. A. Athanasou. 2000. Effect of osteoprotegerin and osteoprotegerin ligand on osteoclast formation by arthroplasty membrane derived macrophages. Ann. Rheum. Dis. 59: 26-31.
7. Ingham, E., and J. Fisher. 2005. The role of macrophages in osteolysis of the total joint replacement. Biomaterials 26: 1217-1286.
8. Möst, J., L. Spötl, G. Mayr, A. Gasser, A. Sarti, and M. P. Dierich. 1997. Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 89: 662-671.
9. 2z receptor of human macrophage cells: characterization and possible physiological role. J. Clin. Invest. 95: 1207-1216.
10. Lemaire, I., H. Yang, W. Lauzon, and N. Gendron. 1996. M-CSF and GM-CSF promote alveolar macrophage differentiation into multinucleated giant cells with distinct phenotypes. J. Leukocyte Biol. 60: 509-518.
11. Lemaire, I., H. Yang, V. Lafond, J. Dornand, T. Commes, and M. F. Cantin. 1996. Differential effects of macrophage- and granulocyte-macrophage colony-stimulating factors on cytokine gene expression during rat alveolar macrophage differentiation into multinucleated giant cells (MGC). J. Immunol. 157: 5118-5125.
12. Murch, A. R., M. D. Grounds, C. A. Marshall, and J. M. Papadimitriou. 1982. Direct evidence that inflammatory multinucleated giant cells form by fusion. J. Pathol. 137: 177-180.
13. Möst, J., H. P. Neumayer, and M. P. Dierich. 1990. Cytokine-induced generation of multinucleated giant cells in vitro requires interferon-γ and expression of LFA-1. Eur. J. Immunol. 20: 1661-1667.
14. Fais, S., V. L. Burgio, M. Silvesti, M. R. Capobianchi, A. Pacchiarotti, and F. Pallone. 1994. Multinucleated giant cells generation induced by IFN-γ: changes in the expression and distribution of the intercellular adhesion molecule-1 during macrophages fusion and multinucleated giant cell formation. Lab. Invest. 71: 737-744.
15. McInnes, A., and D. M. Rennick. 1988. Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells. J. Exp. Med. 167: 598-611.
16. 2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am. J. Pathol. 160: 621-630.
17. Byrd, T. F. 1998. Multinucleated giant cell formation induced by IFN-γ/IL-3 is associated with restriction of virulent Mycobacterium tuberculosis cell to cell invasion in human monocyte monolayers. Cell. Immunol. 188: 89-96.
18. Saginario, C., H. Sterling, C. Beckers, R. Kobayashi, M. Solimena, E. Ullu, and A. Vignery. 1998. MFR, a putative receptor mediating the fusion of macrophages. Mol. Cell. Biol 18: 6213-6223.
19. Kyriakides, T. R., M. J. Foster, G. E. Keeney, A. Tsai, C. M. Giachelli, I. Clark-Lewis, B. J. Rollins, and P. Bornstein. 2004. The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am. J. Pathol. 165: 2157-2166.
20. Bonnema, H., E. R. Popa, M. M. Van Timmeren, P. B. Van Wachem, L. F. M. H. de Leij, and M. J. Van Luyn. 2003. Distribution pattern of the membrane glycoprotein CD44 during the foreign-body reaction to a degradable biomaterial in rats and mice. J. Biomed. Mater. Res. 64: 502-508 (Pt. A).
21. Vignery, A. 2005. Macrophage fusion: the making of osteoclasts and giant cells. J. Exp. Med. 202: 337-340.
22. Yagi, M., T. Miyamoto, Y. Sawatani, K. Iwamoto, N. Hosogane, N. Fujita, K. Morita, K. Ninomiya, T. Suzuki, K. Miyamoto, et al. 2005. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202: 345-351.
23. 7): cloning and expression of human cDNA. J. Biol. Chem. 272: 5482-5486.
24. Steinberg, T. H., A. S. Newman, J. H. Swanson, and S. C. Silverstein. 1987. ATP4-permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes. J. Biol. Chem. 262: 8884-8888.
25. 7 receptor and polykarion formation. Mol. Biol. Cell 11: 3169-3176.
26. 7 receptor. J. Cell Biol. 138: 697-706.
27. Mizuno, K., H. Okamoto, and T. Horio. 2001. Heightened ability of monocytes from sarcoidosis patients to form multi-nucleated giant cells in vitro by supernatants of concanavalin A-stimulated mononuclear cells. Clin. Exp. Immunol. 126: 151-156.
28. Mizuno, K., H. Okamoto, and T. Horio. 2004. Inhibitory influences of xanthine oxidase inhibitor and angiotensin I-converting enzyme inhibitor on multinucleated giant cell formation from monocytes by downregulation of adhesion molecules and purinergic receptors. Br. J. Dermatol. 150: 205-210.
29. Luttikhuizen, D. T., M. C. Harmsen, L. F. de Leiji, and M. J. Van Luyn. 2004. Expression of P2 receptors at sites of chronic inflammation. Cell Tissue Res. 317; 289-298.
30. Modderman, W. E., A. F. Weiderman, J. Vrijheid-Lammers, A. M. Wassenaar, and P. J. Nijweide. 1994. Permeabilization of cells of hematopoietic origin by extracellular ATP4: elimination of osteoclasts, macrophages and their precursors from isolated bone cell populations and fetal bone rudiments. Calcif. Tissue Int. 55: 141-150.
31. 7 activation. Crit. Rev. Eukaryotic Gene Expression 13: 237-242.
32. 7 receptor inhibits formation of multinucleated human osteoclasts in vitro. Calcif. Tissue Int. 73: 361-369.
33. 7 and inhibits osteoclast formation in RAW cells. Am. J. Physiol. 287: C403-C412.
34. Ke, H. Z., H. Qi, A. F. Weidema, Q. Zhang, N. Panupinthu, D. T. Crawford, W. A. Grasser, V. M. Paralkar, M. Li, L. P. Audoly, et al. 2003. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol. Endocrinol. 17: 1356-1367.
35. 7-transfected HEK 293 cells. Mol. Biol. Cell 14: 2655-2664.
36. 7 receptor function. J. Immunol. 173: 4652-4660.
37. 7 receptor function in lung alveolar macrophages: pharmacologic characterization and bidirectional regulation by Th1 and Th2 cytokines. Drug Dev. Res. 59: 118-127.
38. Z receptor. J. Biol. Chem. 268: 8199-8203.
39. 7 receptors. Mol. Pharmacol. 58: 82-88.
40. 7 receptors in rat peritoneal cells. Inflamm. Res. 54: 119-126.
41. 7 receptor signaling complex. EMBO J. 20: 6347-6358.
42. Pellegatti, P., S. Falzoni, P. Pinton, R. Rizzuto, and F. Di Virgilio. 2005. A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion. Mol. Biol. Cell 16: 3659-3665.
43. 7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol. Biol. Cell 16: 3260-3272.
44. 7 receptors. J. Biol. Chem. 280: 33968-33976.
45. van den Eijnde, S. M., M. J. B. van den Hoff, C. P. M. Reutelingsperger, W. L. van Heerde, M. E. R. Henning, C. Vermeij, B. Schutte, M. Borgers, and F. C. S. Ramaekers. 2001. Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation. J. Cell Sci. 114: 3631-3642.
46. Das, M., B. Xu, L. Lin, S. Chakrabarti, V. Shivaswamy, and N. S. Rote. 2004. Phosphatidylserine efflux and intercellular fusion in a BeWo model of human villous cytotrophoblast. Placenta 25: 396-407.
47. Lemaire, I. 1991. Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis. Am. J. Pathol. 138: 487-495.
48. Di Virgilio, F., P. Chiozzi, D. Ferrari, S. Falzoni, J. M. Sanz, A. Morelli, M. Torboli, G. Bolognesi, and O. R. Baricordi. 2001. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97: 587-600.