Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose

Biochemistry

Volumn 48, Issue 4, 2009, Pages 786-791

  Di Lella, Santiago ^a,b   Ma, Lu ^c   Díaz Ricci, Juan C ^a   Rabinovich, Gabriel A ^d   Asher, Sanford A ^c   Álvarez, R María S ^a  

^a UNIVERSIDAD NACIONAL DE TUCUMÁN   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d CONICET ^*  (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEINS; CARBOHYDRATE LIGANDS; CARBOHYDRATE-RECOGNITION DOMAINS; DISACCHARIDE LACTOSE; GALECTIN-1; GLYCOCONJUGATES; IMMUNE CELLS; INFLAMMATORY RESPONSE; LIGAND BINDINGS; MOLECULAR DYNAMIC SIMULATIONS; PHYSICO-CHEMICAL PROPERTIES; RADIAL DISTRIBUTION FUNCTIONS; ROLE OF WATERS; SOLVENT ENVIRONMENTS; SOLVENT REORGANIZATIONS; STRUCTURAL CHANGES; SYNTHETIC INHIBITORS; TUMOR PROGRESSIONS; UV-RAMAN SPECTRUM; UV-RESONANCE RAMAN SPECTROSCOPIES;

AMINO ACIDS; BIOCHEMISTRY; LIGANDS; MOLECULAR DYNAMICS; ORGANIC COMPOUNDS; POLYSACCHARIDES; RAMAN SCATTERING; RAMAN SPECTROSCOPY; SUGARS;

DISTRIBUTION FUNCTIONS;

CARBOHYDRATE; DISACCHARIDE; GALECTIN 1; GLYCAN; LACTOSE; SOLVENT; TRYPTOPHAN; LGALS1 PROTEIN, HUMAN; WATER;

ARTICLE; GENETIC CONSERVATION; HOMEOSTASIS; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN FAMILY; RAMAN SPECTROMETRY; TUMOR GROWTH; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; METABOLISM; PROTEIN BINDING; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; GALECTIN 1; HUMANS; LACTOSE; MODELS, CHEMICAL; PROTEIN BINDING; SOLVENTS; SPECTRUM ANALYSIS, RAMAN; THERMODYNAMICS; WATER;

EID: 60749084683     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801855g     Document Type: Article

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