메뉴 건너뛰기




Volumn 71, Issue 5, 2009, Pages 1190-1204

Legionella pneumophila couples fatty acid flux to microbial differentiation and virulence

Author keywords

[No Author keywords available]

Indexed keywords

2 FUROIC ACID DERIVATIVE; 5 TETRADECYLOXY 2 FUROIC ACID; ACYL CARRIER PROTEIN; CERULENIN; PROTEIN SPOT; SHORT CHAIN FATTY ACID; SYNTHETASE; UNCLASSIFIED DRUG;

EID: 60649109691     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06593.x     Document Type: Article
Times cited : (55)

References (76)
  • 2
    • 0033794464 scopus 로고    scopus 로고
    • Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila
    • Alli, O.A.T., Gao, L.-Y., Pedersen, L.L., Zink, S., Radulic, M., Doric, M. Abu Kwaik, Y. (2000) Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila. Infect Immun 68 : 6431 6440.
    • (2000) Infect Immun , vol.68 , pp. 6431-6440
    • Alli, O.A.T.1    Gao, L.-Y.2    Pedersen, L.L.3    Zink, S.4    Radulic, M.5    Doric, M.6    Abu Kwaik, Y.7
  • 3
    • 17844385542 scopus 로고    scopus 로고
    • Mycobacterium avium enters a state of metabolic dormancy in response to starvation
    • Archuleta, R.J., Hoppes, P.Y. Primm, T.P. (2005) Mycobacterium avium enters a state of metabolic dormancy in response to starvation. Tuberculosis 85 : 147 158.
    • (2005) Tuberculosis , vol.85 , pp. 147-158
    • Archuleta, R.J.1    Hoppes, P.Y.2    Primm, T.P.3
  • 4
    • 0034968828 scopus 로고    scopus 로고
    • RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase
    • Bachman, M.A. Swanson, M.S. (2001) RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase. Mol Microbiol 40 : 1201 1214.
    • (2001) Mol Microbiol , vol.40 , pp. 1201-1214
    • Bachman, M.A.1    Swanson, M.S.2
  • 5
    • 2142810201 scopus 로고    scopus 로고
    • Genetic evidence that Legionella pneumophila RpoS modulates expression of the transmission phenotype in both the exponential phase and the stationary phase
    • Bachman, M.A. Swanson, M.S. (2004a) Genetic evidence that Legionella pneumophila RpoS modulates expression of the transmission phenotype in both the exponential phase and the stationary phase. Infect Immun 72 : 2468 2476.
    • (2004) Infect Immun , vol.72 , pp. 2468-2476
    • Bachman, M.A.1    Swanson, M.S.2
  • 6
    • 2542523185 scopus 로고    scopus 로고
    • The LetE protein enhances expression of multiple LetA/LetS-dependent transmission traits by Legionella pneumophila
    • Bachman, M.A. Swanson, M.S. (2004b) The LetE protein enhances expression of multiple LetA/LetS-dependent transmission traits by Legionella pneumophila. Infect Immun 72 : 3284 3293.
    • (2004) Infect Immun , vol.72 , pp. 3284-3293
    • Bachman, M.A.1    Swanson, M.S.2
  • 7
    • 33750479525 scopus 로고    scopus 로고
    • Acyl carrier protein/SpoT interaction, the switch linking SpoT-dependent stress response to fatty acid metabolism
    • Battesti, A. Bouveret, E. (2006) Acyl carrier protein/SpoT interaction, the switch linking SpoT-dependent stress response to fatty acid metabolism. Mol Microbiol 62 : 1048 1063.
    • (2006) Mol Microbiol , vol.62 , pp. 1048-1063
    • Battesti, A.1    Bouveret, E.2
  • 8
    • 0027472133 scopus 로고
    • Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila
    • Berger, K.H. Isberg, R.R. (1993) Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol 7 : 7 19.
    • (1993) Mol Microbiol , vol.7 , pp. 7-19
    • Berger, K.H.1    Isberg, R.R.2
  • 9
    • 0028104489 scopus 로고
    • Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene
    • Berger, K.H., Merriam, J.J. Isberg, R.R. (1994) Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene. Mol Microbiol 14 : 809 822.
    • (1994) Mol Microbiol , vol.14 , pp. 809-822
    • Berger, K.H.1    Merriam, J.J.2    Isberg, R.R.3
  • 10
    • 84883841228 scopus 로고
    • Resistance of mouse's intestinal tract to experimental Salmonella infection. I. Factors which interfere with the initiation of infection by oral inoculation
    • Bohnhoff, M., Miller, C.P. Martin, W.R. (1964) Resistance of mouse's intestinal tract to experimental Salmonella infection. I. Factors which interfere with the initiation of infection by oral inoculation. J Exp Med 120 : 805 816.
    • (1964) J Exp Med , vol.120 , pp. 805-816
    • Bohnhoff, M.1    Miller, C.P.2    Martin, W.R.3
  • 11
    • 0027956705 scopus 로고
    • The modular architecture of bacterial response regulators: Insights into the activation mechanism of the BvgA transactivator of Bordetella pertussis
    • Boucher, P.E., Menozzi, F.D. Locht, C. (1994) The modular architecture of bacterial response regulators: insights into the activation mechanism of the BvgA transactivator of Bordetella pertussis. J Mol Biol 241 : 363 377.
    • (1994) J Mol Biol , vol.241 , pp. 363-377
    • Boucher, P.E.1    Menozzi, F.D.2    Locht, C.3
  • 12
    • 32444449511 scopus 로고    scopus 로고
    • The global regulatory proteins LetA and RpoS control phospholipase A, lysophospholipase A, acyltransferase, and other hydrolytic activities of Legionella pneumophila JR32
    • Broich, M., Rydzewski, K., McNealy, T.L., Marre, R. Flieger, A. (2006) The global regulatory proteins LetA and RpoS control phospholipase A, lysophospholipase A, acyltransferase, and other hydrolytic activities of Legionella pneumophila JR32. J Bacteriol 188 : 1218 1226.
    • (2006) J Bacteriol , vol.188 , pp. 1218-1226
    • Broich, M.1    Rydzewski, K.2    McNealy, T.L.3    Marre, R.4    Flieger, A.5
  • 13
    • 33745767998 scopus 로고    scopus 로고
    • Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila
    • Bruggemann, H., Hagman, A., Jules, M., Sismeiro, O., Dillies, M.A., Gouyette, C., et al. (2006) Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila. Cell Microbiol 8 : 1228 1240.
    • (2006) Cell Microbiol , vol.8 , pp. 1228-1240
    • Bruggemann, H.1    Hagman, A.2    Jules, M.3    Sismeiro, O.4    Dillies, M.A.5    Gouyette, C.6
  • 14
    • 0018164730 scopus 로고
    • Inhibition of unsaturated fatty acid synthesis in Escherichia coli by the antibiotic cerulenin
    • Buttke, T.M. Ingram, L.O. (1978) Inhibition of unsaturated fatty acid synthesis in Escherichia coli by the antibiotic cerulenin. Biochemistry 17 : 5282 5286.
    • (1978) Biochemistry , vol.17 , pp. 5282-5286
    • Buttke, T.M.1    Ingram, L.O.2
  • 15
    • 0031841662 scopus 로고    scopus 로고
    • Expression of Legionella pneumophila virulence traits in response to growth conditions
    • Byrne, B. Swanson, M.S. (1998) Expression of Legionella pneumophila virulence traits in response to growth conditions. Infect Immun 66 : 3029 3034.
    • (1998) Infect Immun , vol.66 , pp. 3029-3034
    • Byrne, B.1    Swanson, M.S.2
  • 16
    • 0014690559 scopus 로고
    • The control of ribonucleic acid synthesis in Escherichia coli
    • Cashel, M. (1969) The control of ribonucleic acid synthesis in Escherichia coli. J Biol Chem 244 : 3133 3141.
    • (1969) J Biol Chem , vol.244 , pp. 3133-3141
    • Cashel, M.1
  • 17
    • 0000494717 scopus 로고
    • Detection of (p)ppGpp accumulation patterns in Escherichia coli mutants. In. Adolph, K.W. (ed.). New York: Academic Press, pp.
    • Cashel, M. (1994) Detection of (p)ppGpp accumulation patterns in Escherichia coli mutants. In Adolph, K.W. (ed.). Methods in Molecular Genetics, Vol. 3. Molecular Microbiology Techniques, Part A. New York : Academic Press, pp. 341 356.
    • (1994) Methods in Molecular Genetics , vol.3 , pp. 341-356
    • Cashel, M.1
  • 18
    • 10044263696 scopus 로고    scopus 로고
    • Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity
    • Cazalet, C., Rusniok, C., Bruggemann, H., Zidane, N., Magnier, A., Ma, L., et al. (2004) Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet 36 : 1165 1173.
    • (2004) Nat Genet , vol.36 , pp. 1165-1173
    • Cazalet, C.1    Rusniok, C.2    Bruggemann, H.3    Zidane, N.4    Magnier, A.5    Ma, L.6
  • 19
    • 4644276577 scopus 로고    scopus 로고
    • The genomic sequence of the accidental pathogen Legionella pneumophila
    • Chien, M., Morozova, I., Shi, S., Sheng, H., Chen, J., Gomez, S.M., et al. (2004) The genomic sequence of the accidental pathogen Legionella pneumophila. Science 305 : 1966 1968.
    • (2004) Science , vol.305 , pp. 1966-1968
    • Chien, M.1    Morozova, I.2    Shi, S.3    Sheng, H.4    Chen, J.5    Gomez, S.M.6
  • 20
    • 0017839019 scopus 로고
    • Ketogenesis and malonyl coenzyme A content of isolated rat hepatocytes
    • Cook, G.A., King, M.T. Veech, R.L. (1978) Ketogenesis and malonyl coenzyme A content of isolated rat hepatocytes. J Biol Chem 253 : 2529 2531.
    • (1978) J Biol Chem , vol.253 , pp. 2529-2531
    • Cook, G.A.1    King, M.T.2    Veech, R.L.3
  • 21
    • 58449098832 scopus 로고    scopus 로고
    • SpoT governs Legionella pneumophila differentiation in host macrophages
    • Dalebroux, ZD, Edwards, R.L. Swanson M.S 2009) SpoT governs Legionella pneumophila differentiation in host macrophages. Mol Microbiol 71 : 640 658.
    • (2009) Mol Microbiol , vol.71 , pp. 640-658
    • Dalebroux, Z.D.1    Edwards, R.L.2    Swanson, M.S.3
  • 22
    • 0031983015 scopus 로고    scopus 로고
    • The fats of Escherichia coli during infancy and old age: Regulation by global regulators, alarmones and lipid intermediates
    • DiRusso, C.C. Nystrom, T. (1998) The fats of Escherichia coli during infancy and old age: regulation by global regulators, alarmones and lipid intermediates. Mol Microbiol 27 : 1 8.
    • (1998) Mol Microbiol , vol.27 , pp. 1-8
    • Dirusso, C.C.1    Nystrom, T.2
  • 23
    • 0036956039 scopus 로고    scopus 로고
    • Ultrastructural analysis of differentiation in Legionella pneumophila
    • Faulkner, G. Garduno, R.A. (2002) Ultrastructural analysis of differentiation in Legionella pneumophila. J Bacteriol 184 : 7025 7041.
    • (2002) J Bacteriol , vol.184 , pp. 7025-7041
    • Faulkner, G.1    Garduno, R.A.2
  • 24
    • 33646918848 scopus 로고    scopus 로고
    • Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes
    • Fernandez-Moreira, E., Helbig, J.H. Swanson, M.S. (2006) Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes. Infect Immun 74 : 3285 3295.
    • (2006) Infect Immun , vol.74 , pp. 3285-3295
    • Fernandez-Moreira, E.1    Helbig, J.H.2    Swanson, M.S.3
  • 25
    • 0034756249 scopus 로고    scopus 로고
    • Overexpression of a Legionella pneumophila homologue of the E. coli regulator csrA affects cell size, flagellation and pigmentation
    • Fettes, P.S., Forsbach-Birk, V., Lynch, D. Marre, R. (2001) Overexpression of a Legionella pneumophila homologue of the E. coli regulator csrA affects cell size, flagellation and pigmentation. Int J Med Microbiol 291 : 353 360.
    • (2001) Int J Med Microbiol , vol.291 , pp. 353-360
    • Fettes, P.S.1    Forsbach-Birk, V.2    Lynch, D.3    Marre, R.4
  • 26
    • 0036314980 scopus 로고    scopus 로고
    • Legionella and Legionnaires' disease: 25 years of investigation
    • Fields, B.S., Benson, R.F. Besser, R.E. (2002) Legionella and Legionnaires' disease: 25 years of investigation. Clin Microbiol Rev 15 : 506 526.
    • (2002) Clin Microbiol Rev , vol.15 , pp. 506-526
    • Fields, B.S.1    Benson, R.F.2    Besser, R.E.3
  • 27
    • 0034662484 scopus 로고    scopus 로고
    • Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids
    • Flieger, A., Gong, S., Faigle, M., Mayer, H.A., Kehrer, U., MuBotter, J., et al. (2000) Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids. FEMS Microbiol Lett 188 : 129 133.
    • (2000) FEMS Microbiol Lett , vol.188 , pp. 129-133
    • Flieger, A.1    Gong, S.2    Faigle, M.3    Mayer, H.A.4    Kehrer, U.5    Mubotter, J.6
  • 28
    • 0036841015 scopus 로고    scopus 로고
    • Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms
    • Garduno, R.A., Garduno, E., Hiltz, M. Hoffman, P.S. (2002) Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms. Infect Immun 70 : 6273 6283.
    • (2002) Infect Immun , vol.70 , pp. 6273-6283
    • Garduno, R.A.1    Garduno, E.2    Hiltz, M.3    Hoffman, P.S.4
  • 29
    • 0036175162 scopus 로고    scopus 로고
    • Role of spoT-dependent ppGpp accumulation in the survival of light-exposed starved bacteria
    • Gong, L., Takayama, K. Kjelleberg, S. (2002) Role of spoT-dependent ppGpp accumulation in the survival of light-exposed starved bacteria. Microbiol 148 : 559 570.
    • (2002) Microbiol , vol.148 , pp. 559-570
    • Gong, L.1    Takayama, K.2    Kjelleberg, S.3
  • 30
    • 0026316230 scopus 로고
    • Phagocytosis of surfactant by alveolar macrophages in vitro
    • Grabner, R. Meerbach, W. (1991) Phagocytosis of surfactant by alveolar macrophages in vitro. Am J Physiol 261 : L472 L477.
    • (1991) Am J Physiol , vol.261
    • Grabner, R.1    Meerbach, W.2
  • 31
    • 0032782866 scopus 로고    scopus 로고
    • Co-ordination of Legionella pneumophila virulence with entry into stationary phase by ppGpp
    • Hammer, B.K. Swanson, M.S. (1999) Co-ordination of Legionella pneumophila virulence with entry into stationary phase by ppGpp. Mol Microbiol 33 : 721 731.
    • (1999) Mol Microbiol , vol.33 , pp. 721-731
    • Hammer, B.K.1    Swanson, M.S.2
  • 32
    • 0036225745 scopus 로고    scopus 로고
    • A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila
    • Hammer, B.K., Tateda, E.S. Swanson, M.S. (2002) A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila. Mol Microbiol 44 : 107 118.
    • (2002) Mol Microbiol , vol.44 , pp. 107-118
    • Hammer, B.K.1    Tateda, E.S.2    Swanson, M.S.3
  • 33
    • 0029045836 scopus 로고
    • Regulation of malonyl-CoA metabolism by acyl-acyl carrier protein and β-ketoacyl-acyl carrier protein synthases in Escherichia coli
    • Heath, R.J. Rock, C.O. (1995) Regulation of malonyl-CoA metabolism by acyl-acyl carrier protein and β-ketoacyl-acyl carrier protein synthases in Escherichia coli. J Biol Chem 270 : 15531 15538.
    • (1995) J Biol Chem , vol.270 , pp. 15531-15538
    • Heath, R.J.1    Rock, C.O.2
  • 35
    • 0022543997 scopus 로고
    • Effect of nutrient deprivation on lipid, carbohydrate, DNA, RNA, and protein levels in Vibrio cholerae
    • Hood, M.A., Guckert, J.B., White, D.C. Deck, F. (1986) Effect of nutrient deprivation on lipid, carbohydrate, DNA, RNA, and protein levels in Vibrio cholerae. Appl Environ Microbiol 52 : 788 793.
    • (1986) Appl Environ Microbiol , vol.52 , pp. 788-793
    • Hood, M.A.1    Guckert, J.B.2    White, D.C.3    Deck, F.4
  • 36
    • 0021112871 scopus 로고
    • Ratio of active to inactive forms of acyl carrier protein in Escherichia coli
    • Jackowski, S. Rock, C.O. (1983) Ratio of active to inactive forms of acyl carrier protein in Escherichia coli. J Biol Chem 258 : 15186 15191.
    • (1983) J Biol Chem , vol.258 , pp. 15186-15191
    • Jackowski, S.1    Rock, C.O.2
  • 37
    • 1942476063 scopus 로고    scopus 로고
    • 54 and the transcriptional regulator FleQ of Legionella pneumophila, which are both involved in the regulation cascade of flagellar gene expression
    • 54 and the transcriptional regulator FleQ of Legionella pneumophila, which are both involved in the regulation cascade of flagellar gene expression. J Bacteriol 186 : 2540 2547.
    • (2004) J Bacteriol , vol.186 , pp. 2540-2547
    • Jacobi, S.1    Schade, R.2    Heuner, K.3
  • 38
    • 0035133794 scopus 로고    scopus 로고
    • Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages
    • Joshi, A.D., Sturgill-Koszycki, S. Swanson, M.S. (2001) Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages. Cell Microbiol 3 : 99 114.
    • (2001) Cell Microbiol , vol.3 , pp. 99-114
    • Joshi, A.D.1    Sturgill-Koszycki, S.2    Swanson, M.S.3
  • 39
    • 0036885883 scopus 로고    scopus 로고
    • Intestinal short-chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA/SirA
    • Lawhon, S.D., Maurer, R., Suyemoto, M. Altier, C. (2002) Intestinal short-chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA/SirA. Mol Microbiol 46 : 1451 1464.
    • (2002) Mol Microbiol , vol.46 , pp. 1451-1464
    • Lawhon, S.D.1    Maurer, R.2    Suyemoto, M.3    Altier, C.4
  • 40
    • 0037469609 scopus 로고    scopus 로고
    • The response regulator LetA regulates the stationary-phase stress response in Legionella pneumophila and is required for efficient infection of Acanthamoeba castellanii
    • Lynch, D., Fieser, N., Gloggler, K., Forsbach-Birk, V. Marre, R. (2003) The response regulator LetA regulates the stationary-phase stress response in Legionella pneumophila and is required for efficient infection of Acanthamoeba castellanii. FEMS Microbiol Lett 219 : 241 248.
    • (2003) FEMS Microbiol Lett , vol.219 , pp. 241-248
    • Lynch, D.1    Fieser, N.2    Gloggler, K.3    Forsbach-Birk, V.4    Marre, R.5
  • 41
    • 0027207516 scopus 로고
    • Is acetyl phosphate a global signal in Escherichia coli?
    • McCleary, W.R., Stock, J.B. Ninfa, A.J. (1993) Is acetyl phosphate a global signal in Escherichia coli? J Bacteriol 175 : 2793 2798.
    • (1993) J Bacteriol , vol.175 , pp. 2793-2798
    • McCleary, W.R.1    Stock, J.B.2    Ninfa, A.J.3
  • 42
    • 0018605657 scopus 로고
    • Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesis
    • McCune, S.A. Harris, R.A. (1979) Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesis. J Biol Chem 254 : 10095 10101.
    • (1979) J Biol Chem , vol.254 , pp. 10095-10101
    • McCune, S.A.1    Harris, R.A.2
  • 43
    • 14544288359 scopus 로고    scopus 로고
    • The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA
    • McNealy, T.L., Forsbach-Birk, V., Shi, C. Marre, R. (2005) The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA. J Bacteriol 187 : 1527 1532.
    • (2005) J Bacteriol , vol.187 , pp. 1527-1532
    • McNealy, T.L.1    Forsbach-Birk, V.2    Shi, C.3    Marre, R.4
  • 44
    • 0027291426 scopus 로고
    • Regulation of fatty acid biosynthesis in Escherichia coli
    • Jr (
    • Magnuson, K., Jackowski, S., Rock, C.O. Cronan, J.E., Jr (1993) Regulation of fatty acid biosynthesis in Escherichia coli. Microbiol Rev 57 : 522 542.
    • (1993) Microbiol Rev , vol.57 , pp. 522-542
    • Magnuson, K.1    Jackowski, S.2    Rock, C.O.3    Cronan, J.E.4
  • 45
  • 46
    • 0142125296 scopus 로고    scopus 로고
    • Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication
    • Molofsky, A.B. Swanson, M.S. (2003) Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication. Mol Microbiol 50 : 445 461.
    • (2003) Mol Microbiol , vol.50 , pp. 445-461
    • Molofsky, A.B.1    Swanson, M.S.2
  • 47
    • 23944485009 scopus 로고    scopus 로고
    • Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death
    • Molofsky, A.B., Shetron-Rama, L.M. Swanson, M.S. (2005) Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infect Immun 73 : 5720 5734.
    • (2005) Infect Immun , vol.73 , pp. 5720-5734
    • Molofsky, A.B.1    Shetron-Rama, L.M.2    Swanson, M.S.3
  • 48
    • 33645843633 scopus 로고    scopus 로고
    • Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
    • Molofsky, A.B., Byrne, B.G., Whitfield, N.N., Madigan, C.A., Fuse, E.T., Tateda, K. Swanson, M.S. (2006) Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med 203 : 1093 1104.
    • (2006) J Exp Med , vol.203 , pp. 1093-1104
    • Molofsky, A.B.1    Byrne, B.G.2    Whitfield, N.N.3    Madigan, C.A.4    Fuse, E.T.5    Tateda, K.6    Swanson, M.S.7
  • 49
    • 0017137380 scopus 로고
    • The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis
    • Omura, S. (1976) The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol Rev 40 : 681 697.
    • (1976) Bacteriol Rev , vol.40 , pp. 681-697
    • Omura, S.1
  • 50
    • 0017726977 scopus 로고
    • Inhibition by 5-(tetradecyloxy)-2-furoic acid of fatty acid and cholesterol synthesis in isolated rat hepatocytes
    • Panek, E., Cook, G.A. Cornell, N.W. (1977) Inhibition by 5-(tetradecyloxy)-2-furoic acid of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Lipids 12 : 814 818.
    • (1977) Lipids , vol.12 , pp. 814-818
    • Panek, E.1    Cook, G.A.2    Cornell, N.W.3
  • 51
    • 0034650757 scopus 로고    scopus 로고
    • Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
    • Pizer, E.S., Thupari, J., Han, W.F., Pinn, M.L., Chrest, F.J., Frehywot, G.L., et al. (2000) Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 60 : 213 218.
    • (2000) Cancer Res , vol.60 , pp. 213-218
    • Pizer, E.S.1    Thupari, J.2    Han, W.F.3    Pinn, M.L.4    Chrest, F.J.5    Frehywot, G.L.6
  • 52
    • 0026058320 scopus 로고
    • In vivo pools of free and acylated acyl carrier proteins in spinach
    • Post-Beittenmiller, D., Jaworski, J.G. Ohlrogge, J.B. (1991) In vivo pools of free and acylated acyl carrier proteins in spinach. J Biol Chem 266 : 1858 1865.
    • (1991) J Biol Chem , vol.266 , pp. 1858-1865
    • Post-Beittenmiller, D.1    Jaworski, J.G.2    Ohlrogge, J.B.3
  • 53
    • 19044394915 scopus 로고    scopus 로고
    • Phenotypic differentiation and seeding dispersal in non-mucoid and mucoid Pseudomonas aeruginosa biofilms
    • Purevdorj-Gage, B., Costerton, W.J. Stoodley, P. (2005) Phenotypic differentiation and seeding dispersal in non-mucoid and mucoid Pseudomonas aeruginosa biofilms. Microbiology 151 : 1569 1576.
    • (2005) Microbiology , vol.151 , pp. 1569-1576
    • Purevdorj-Gage, B.1    Costerton, W.J.2    Stoodley, P.3
  • 54
    • 33645791082 scopus 로고    scopus 로고
    • Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    • Ren, T., Zamboni, D.S., Roy, C.R., Dietrich, W.F. Vance, R.E. (2006) Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog 2 : e18.
    • (2006) PLoS Pathog , vol.2
    • Ren, T.1    Zamboni, D.S.2    Roy, C.R.3    Dietrich, W.F.4    Vance, R.E.5
  • 55
    • 0019345428 scopus 로고
    • Acyl carrier protein from Escherichia coli
    • Jr (
    • Rock, C.O. Cronan, J.E., Jr (1981) Acyl carrier protein from Escherichia coli. Methods Enzymol 71 : 341 351.
    • (1981) Methods Enzymol , vol.71 , pp. 341-351
    • Rock, C.O.1    Cronan, J.E.2
  • 56
    • 0022881556 scopus 로고
    • Current views on the relationships between amoebae, legionellae and man
    • Rowbotham, T.J. (1986) Current views on the relationships between amoebae, legionellae and man. Isr J Med Sci 22 : 678 689.
    • (1986) Isr J Med Sci , vol.22 , pp. 678-689
    • Rowbotham, T.J.1
  • 57
    • 0038051536 scopus 로고    scopus 로고
    • Molecular pathogenesis of Coxiella burnetii in a genomics era
    • Samuel, J.E., Kiss, K. Varghees, S. (2003) Molecular pathogenesis of Coxiella burnetii in a genomics era. Ann N Y Acad Sci 990 : 653 663.
    • (2003) Ann N y Acad Sci , vol.990 , pp. 653-663
    • Samuel, J.E.1    Kiss, K.2    Varghees, S.3
  • 58
    • 22244434967 scopus 로고    scopus 로고
    • The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages
    • Sauer, J.D., Bachman, M.A. Swanson, M.S. (2005) The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages. Proc Natl Acad Sci USA 102 : 9924 9929.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9924-9929
    • Sauer, J.D.1    Bachman, M.A.2    Swanson, M.S.3
  • 59
    • 42549088343 scopus 로고    scopus 로고
    • A malonyl-CoA-dependent switch in the bacterial response to a dysfunction of lipid metabolism
    • Schujman, G.E., Altabe, S. de Mendoza, D. (2008) A malonyl-CoA-dependent switch in the bacterial response to a dysfunction of lipid metabolism. Mol Microbiol 68 : 987 996.
    • (2008) Mol Microbiol , vol.68 , pp. 987-996
    • Schujman, G.E.1    Altabe, S.2    De Mendoza, D.3
  • 60
    • 11844273940 scopus 로고    scopus 로고
    • The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii
    • Segal, G., Feldman, M. Zusman, T. (2005) The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii. FEMS Microbiol Rev 29 : 65 81.
    • (2005) FEMS Microbiol Rev , vol.29 , pp. 65-81
    • Segal, G.1    Feldman, M.2    Zusman, T.3
  • 61
    • 0027483921 scopus 로고
    • SpoT-dependent accumulation of guanosine tetraphosphate in response to fatty acid starvation in Escherichia coli
    • Seyfzadeh, M., Keener, J. Nomura, M. (1993) spoT-dependent accumulation of guanosine tetraphosphate in response to fatty acid starvation in Escherichia coli. Proc Natl Acad Sci USA 90 : 11004 11008.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11004-11008
    • Seyfzadeh, M.1    Keener, J.2    Nomura, M.3
  • 62
    • 30644471298 scopus 로고    scopus 로고
    • The Legionella pneumophila global regulatory protein LetA affects DotA and Mip
    • Shi, C., Forsbach-Birk, V., Marre, R. McNealy, T.L. (2006) The Legionella pneumophila global regulatory protein LetA affects DotA and Mip. Int J Med Microbiol 296 : 15 24.
    • (2006) Int J Med Microbiol , vol.296 , pp. 15-24
    • Shi, C.1    Forsbach-Birk, V.2    Marre, R.3    McNealy, T.L.4
  • 63
    • 42149158392 scopus 로고    scopus 로고
    • Control of bacterial transcription, translation and replication by (p)ppGpp
    • Srivatsan, A. Wang, J.D. (2008) Control of bacterial transcription, translation and replication by (p)ppGpp. Curr Opin Microbiol 11 : 100 105.
    • (2008) Curr Opin Microbiol , vol.11 , pp. 100-105
    • Srivatsan, A.1    Wang, J.D.2
  • 64
    • 0344791690 scopus 로고    scopus 로고
    • Natural competence for DNA transformation by Legionella pneumophila and its association with expression of type IV pili
    • Stone, B.J. Abu Kwaik, Y. (1999) Natural competence for DNA transformation by Legionella pneumophila and its association with expression of type IV pili. J Bacteriol 181 : 1395 1402.
    • (1999) J Bacteriol , vol.181 , pp. 1395-1402
    • Stone, B.J.1    Abu Kwaik, Y.2
  • 65
    • 0034613726 scopus 로고    scopus 로고
    • Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles
    • Sturgill-Koszycki, S. Swanson, M.S. (2000) Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. J Exp Med 192 : 1261 1272.
    • (2000) J Exp Med , vol.192 , pp. 1261-1272
    • Sturgill-Koszycki, S.1    Swanson, M.S.2
  • 66
    • 0029155737 scopus 로고
    • Association of Legionella pneumophila with the macrophage endoplasmic reticulum
    • Swanson, M.S. Isberg, R.R. (1995) Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect Immun 63 : 3609 3620.
    • (1995) Infect Immun , vol.63 , pp. 3609-3620
    • Swanson, M.S.1    Isberg, R.R.2
  • 67
    • 0020646350 scopus 로고
    • Genetic and biochemical analyses of Escherichia coli mutants altered in the temperature-dependent regulation of membrane lipid composition
    • Jr (
    • Ulrich, A.K., de Mendoza, D., Garwin, J.L. Cronan, J.E., Jr (1983) Genetic and biochemical analyses of Escherichia coli mutants altered in the temperature-dependent regulation of membrane lipid composition. J Bacteriol 154 : 221 230.
    • (1983) J Bacteriol , vol.154 , pp. 221-230
    • Ulrich, A.K.1    De Mendoza, D.2    Garwin, J.L.3    Cronan, J.E.4
  • 69
    • 45549092412 scopus 로고    scopus 로고
    • NAIP and Ipaf control Legionella pneumophila replication in human cells
    • Vinzing, M., Eitel, J., Lippmann, J., Hocke, A.C., Zahlten, J., Slevogt, H., et al. (2008) NAIP and Ipaf control Legionella pneumophila replication in human cells. J Immunol 180 : 6808 6815.
    • (2008) J Immunol , vol.180 , pp. 6808-6815
    • Vinzing, M.1    Eitel, J.2    Lippmann, J.3    Hocke, A.C.4    Zahlten, J.5    Slevogt, H.6
  • 70
    • 0018758041 scopus 로고
    • Growth of Legionnaires disease bacterium (Legionella pneumophila) in chemically defined medium
    • Warren, W.J. Miller, R.D. (1979) Growth of Legionnaires disease bacterium (Legionella pneumophila) in chemically defined medium. J Clin Microbiol 10 : 50 55.
    • (1979) J Clin Microbiol , vol.10 , pp. 50-55
    • Warren, W.J.1    Miller, R.D.2
  • 71
    • 0035887426 scopus 로고    scopus 로고
    • Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus
    • Watarai, M., Derre, I., Kirby, J., Growney, J.D., Dietrich, W.F. Isberg, R.R. (2001) Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus. J Exp Med 194 : 1081 1096.
    • (2001) J Exp Med , vol.194 , pp. 1081-1096
    • Watarai, M.1    Derre, I.2    Kirby, J.3    Growney, J.D.4    Dietrich, W.F.5    Isberg, R.R.6
  • 72
    • 0037129846 scopus 로고    scopus 로고
    • Regulation of the Legionella mip-promotor during infection of human monocytes
    • Wieland, H., Faigle, M., Lang, F., Northoff, H. Neumeister, B. (2002) Regulation of the Legionella mip-promotor during infection of human monocytes. FEMS Microbiol Lett 212 : 127 132.
    • (2002) FEMS Microbiol Lett , vol.212 , pp. 127-132
    • Wieland, H.1    Faigle, M.2    Lang, F.3    Northoff, H.4    Neumeister, B.5
  • 73
    • 14844304337 scopus 로고    scopus 로고
    • Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5
    • Wieland, H., Ullrich, S., Lang, F. Neumeister, B. (2005) Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5. Mol Microbiol 55 : 1528 1537.
    • (2005) Mol Microbiol , vol.55 , pp. 1528-1537
    • Wieland, H.1    Ullrich, S.2    Lang, F.3    Neumeister, B.4
  • 74
    • 14944368136 scopus 로고    scopus 로고
    • The acetate switch
    • Wolfe, A.J. (2005) The acetate switch. Micro Mol Biol Rev 69 : 12 50.
    • (2005) Micro Mol Biol Rev , vol.69 , pp. 12-50
    • Wolfe, A.J.1
  • 75
    • 0242694902 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells
    • Zhou, W., Simpson, P.J., McFadden, J.M., Townsend, C.A., Medghalchi, S.M., Vadlamudi, A., et al. (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res 63 : 7330 7337.
    • (2003) Cancer Res , vol.63 , pp. 7330-7337
    • Zhou, W.1    Simpson, P.J.2    McFadden, J.M.3    Townsend, C.A.4    Medghalchi, S.M.5    Vadlamudi, A.6
  • 76
    • 0036136235 scopus 로고    scopus 로고
    • Characterization of a Legionella pneumophila relA insertion mutant and toles of RelA and RpoS in virulence gene expression
    • Zusman, T., Gal-Mor, O. Segal, G. (2002) Characterization of a Legionella pneumophila relA insertion mutant and toles of RelA and RpoS in virulence gene expression. J Bacteriol 184 : 67 75.
    • (2002) J Bacteriol , vol.184 , pp. 67-75
    • Zusman, T.1    Gal-Mor, O.2    Segal, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.