Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 5, 2009, Pages 1413-1415

  Wang, Meng ^a   Opare, Peter ^a   Boddy, Christopher N ^a,b  

^a SYRACUSE UNIVERSITY   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Enzyme kinetics; Peptidyl thioester; Polyketide; Substrate specificity; Thioesterase

Indexed keywords

AMINO ACID; EPOTHILONE DERIVATIVE; ERYTHROMYCIN; GRAMICIDIN S; MALONYL COENZYME A; NATAMYCIN; POLYKETIDE SYNTHASE; THIOL ESTER HYDROLASE; TYROCIDINE;

ACYLATION; ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; IN VITRO STUDY; MICHAELIS CONSTANT; NONHUMAN; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; RNA TRANSLATION; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

CATALYSIS; ESTERIFICATION; ESTERS; HYDROLYSIS; PEPTIDES; POLYKETIDE SYNTHASES;

EID: 60449103101     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.040     Document Type: Article

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