Bak to Basics of Colonocyte Renewal

Gastroenterology

Volumn 136, Issue 3, 2009, Pages 763-766

  Susnow, Nathan J ^a   Hockenbery, David M ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAK; PROTEIN BCL 2;

APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; CELL KINETICS; EDITORIAL; PRIORITY JOURNAL;

EID: 60449097536     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.01.021     Document Type: Editorial

References (27)

1. Maskens A.P., and Dujardin-Loits R.M. Kinetics of tissue proliferation in colorectal mucosa during post-natal growth. Cell Tissue Kinet 14 (1981) 467-477
2. Eastwood G.L. Gastrointestinal epithelial renewal. Gastroenterology 72 (1977) 962-975
3. Cai W.B., Roberts S.A., and Potten C.S. The number of clonogenic cells in crypts in three regions of murine large intestine. Int J Radiat Biol 71 (1997) 573-579
4. Merritt A.J., Potten C.S., Watson A.J., et al. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci 108 (1995) 2261-2271
5. Hockenbery D.M., Zutter M., Hickey W., et al. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A 88 (1991) 6961-6965
6. Lakshman M., Subramaniam V., and Jothy S. CD44 negatively regulates apoptosis in murine colonic epithelium via the mitochondrial pathway. Exp Mol Pathol 76 (2004) 196-204
7. Pritchard D.M., Potten C.S., Korsmeyer S.J., et al. Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 18 (1999) 7287-7293
8. Hoyes K.P., Cai W.B., Potten C.S., et al. Effect of bcl-2 deficiency on the radiation response of clonogenic cells in small and large intestine, bone marrow and testis. Int J Radiat Biol 76 (2000) 1435-1442
9. Pritchard D.M., Print C., O'Reilly L., et al. Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine. Oncogene 19 (2000) 3955-3959
10. Wilson J.W., and Potten C.S. Immunohistochemical localization of BAX and BAD in the normal and BCL-2 null gastrointestinal tract. Apoptosis 1 (1996) 183-190
11. di Masi A., Antoccia A., Dimauro I., et al. Gene expression and apoptosis induction in p53-heterozygous irradiated mice. Mutat Res 594 (2006) 49-62
12. Duckworth C.A., and Pritchard D.M. Suppression of apoptosis, crypt hyperplasia and altered differentiation in the colonic epithelia of bak-null mice. Gastroenterology 136 (2009) 943-952
13. Krajewski S., Krajewska M., and Reed J.C. Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family. Cancer Res 56 (1996) 2849-2855
14. Lindsten T., Ross A.J., King A., et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6 (2000) 1389-1399
15. Janumyan Y., Cui Q., Yan L., et al. G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. J Biol Chem 283 (2008) 34108-34120
16. Liberman E., Naumov I., Kazanov D., et al. Malignant transformation of normal enterocytes following downregulation of Bak expression. Digestion 77 (2008) 48-56
17. Degenhardt K., Chen G., Lindsten T., et al. BAX and BAK mediate p53-independent suppression of tumorigenesis. Cancer Cell 2 (2002) 193-203
18. Krajewska M., Moss S.F., Krajewski S., et al. Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 56 (1996) 2422-2427
19. Ogura E., Senzaki H., Yamamoto D., et al. Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas. Oncol Rep 6 (1999) 365-369
20. Sakamoto I., Yamada T., Ohwada S., et al. Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers. Int J Mol Med 13 (2004) 53-55
21. Knudson C.M., Johnson G.M., Lin Y., et al. Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res 61 (2001) 659-665
22. Jamerson M.H., Johnson M.D., Korsmeyer S.J., et al. Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice. Br J Cancer 91 (2004) 1372-1379
23. Izeradjene K., Combs C., Best M., et al. Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11 (2007) 229-243
24. Aiken K.D., and Roth K.A. Temporal differentiation and migration of substance P, serotonin, and secretin immunoreactive enteroendocrine cells in the mouse proximal small intestine. Dev Dyn 194 (1992) 303-310
25. Haughn L., Hawley R.G., Morrison D.K., et al. BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation. J Biol Chem 278 (2003) 25158-25165
26. Wei M.C., Zong W.X., Cheng E.H., et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292 (2001) 727-730
27. Gassler N., Roth W., Funke B., et al. Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. Gastroenterology 133 (2007) 587-598