Immunohistochemical localization of BAX and BAD in the normal and BCL-2 null gastrointestinal tract

Apoptosis

Volumn 1, Issue 3, 1996, Pages 183-190

  Wilson, J W ^a   Potten, C S ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; BAD; BAX; Gastrointestinal tract; Stem cells

Indexed keywords

EID: 0001388368     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01321101     Document Type: Article

References (9)

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2. Oltavi ZN, Milliman CL, Korsmeyer SJ. BCL-2 heterodimerises in vivo with a conserved homolog, BAX, that accelerates programmed cell death. Cell 1993; 74: 609-619.
3. Zhan Q, Fan S, Bae I, et al. Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 1994; 9: 3743-3751.
4. Gillardon F, Wickert H, Zimmermann M. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett 1995; 192: 85-88.
5. Bargou RC, Bommert K, Weinmann P, et al. Induction of bax-alpha precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 family in surface IgM-mediated apoptosis. Eur J Immunol 1995a; 6: 770-775.
6. Bargou RC, Daniel PT, Mapara MY, et al. Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumour cells correlates with resistance towards apoptosis. Int J Cancer 1995b; 60: 854-859.
7. Krajewski S, Blomqvist C, Franssila K, et al. Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res 1995; 55: 4471-4478.
8. 1: a paradigm for distinct apoptotic pathways. Oncogene 1994; 9: 1791-1798.
9. Miyashita T, Reed JC. Tumour suppressor p53 is a direct transcriptional activator of the human fexgene. Cell 1995; 80: 293-299.