Fluoride-induced ultrastructural changes in exocrine pancreas cells of rats: Fluoride disrupts the export of zymogens from the rough endoplasmic reticulum (rER)

Archives of Toxicology

Volumn 73, Issue 12, 2000, Pages 611-617

  Matsuo, Saburou ^a   Nakagawa, Hiroshi ^a   Kiyomiya, Ken Ichi ^a   Kurebe, Masaru ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Autophagosome; Exocrine pancreas cell; Fluoride; Intracellular transport

Indexed keywords

ENZYME PRECURSOR; FLUORIDE; FLUORIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENAMEL; EXOCRINE CELL; FLUOROSIS; INTRACELLULAR TRANSPORT; MALE; NONHUMAN; PANCREAS INJURY; PHAGOSOME; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; ROUGH ENDOPLASMIC RETICULUM;

EID: 0034056208     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050015     Document Type: Article

References (36)

1. Arias AE, Bendayan M (1993) Intracisternal crystals in pancreatic acinar cells: failure in the distinct aggregation of secretory proteins. Eur J Cell Biol 62: 282-293
2. Arias AE, Vélez-Granell CS, Torres-Ruíz JA, Bendayan M (1994) Involvement of molecular chaperones in the aberrant aggregation of secretory proteins in pancreatic acinar cells. Exp Cell Res 215: 1-8
3. Arstila AU, Trump BF (1968) Studies on cellular autophagocytosis. The formation of autophagic vacuoles in the liver after glucagon administration. Am J Pathol 53: 687-733
4. Bhusshy BR (1959) Chemical and physical studies of enamel from human teeth: density and nitrogen content of mottled enamel. J Dent Res 38: 369-373
5. Bieger W, Kern HF (1975) Studies of intracellular transport in the rat exocrine pancreas. I. Inhibition by aromatic amino acids in vitro. Virchows Arch A Pathol Anat Histol 367: 289-305
6. Den Besten PK, Crenshaw MA (1984) The effects of chronic high fluoride levels on forming enamel in the rat. Arch Oral Biol 29: 675-679
7. Dunn WA Jr (1990a) Studies on the mechanisms of autophagy: Formation of the autophagic vacuole. J Cell Biol 110: 1923-1933
8. Dunn WA Jr (1990b) Studies on the mechanisms of autophagy: Maturation of the autophagic vacuole. J Cell Biol 110: 1935-1945
9. Ericsson JLE (1969) Studies on induced cellular autophagy. II. Characterization of the membranes bordering autophagosomes in parenchymal liver cells. Exp Cell Res 56: 393-405
10. Farquhar MG (1971) Processing of secretory products by cells of the anterior pituitary gland. In: Heller H, Lederis K (eds) Sub-cellular structure and function in endocrine organs. Cambridge University Press, Cambridge, pp 79-122
11. Forssmann WG, Bieger W (1973) Biosynthese falscher proteine: einbau von p-C-Phe in enzyme des exokrinen pankreas. Res Exp Med 160: 1-20
12. Friend DS (1969) Cytochemical staining of multivesicular body and Golgi vesicles. J Cell Biol 41: 269-279
13. Geuze HJ, Slot JW (1980) Disproportional immunostaining patterns of two secretory proteins in guinea pig and rat exocrine pancreatic cells. An immunoferritin and fluorescence study. Eur J Cell Biol 21: 93-100
14. Kern HF, Kern D (1969) Elektronemikroskopische Untersuchungen ber die Wirkung von Kobaltchlorid auf das exokrine Pankreasgewebe des Meerschweinchens. Virchows Arch Abt B Zellpathol 4: 54-70
15. Kömüves LG, Nichols BL, Hutchens W, Heath JP (1993) Formation of crystalloid inclusions in the small intestine of neonatal pigs: an immunocytochemical study using colloidal gold. Histochem J 25: 19-29
16. Kruger BJ (1968) Ultrastructural changes in ameloblasts from fluoride treated rats. Arch Oral Biol 13: 969-977
17. Kruger BJ (1970) The effect of different levels of fluoride on the ultrastructure of ameloblasts in the rat. Arch Oral Biol 15: 109-114
18. Lyaruu DM, De Jong M, Wöltgens JHM (1986) Ultrastructural study of fluoride-induced hypermineralization of enamel in hamster tooth germs explanted during the secretory phase of amelogenesis. Arch Oral Biol 31: 109-117
19. Matsuo S, Inai T, Kurisu K, Kiyomiya K, Kurebe M (1996) Influence of fluoride on secretory pathway of the secretory ameloblast in rat incisor tooth germs exposed to sodium fluoride. Arch Toxicol 70: 420-429
20. Matsuo S, Kiyomiya K, Kurebe M (1998) Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride. Arch Toxicol 72: 798-806
21. Mornstad H, Hammarstrom L (1978) Morphologic changes in the rat enamel organ following a single intraperitoneal injection of sodium fluoride. Scand J Dent Res 86: 211-220
22. Oliver C, Auth RE, Hand AR (1979) Formation and fate of ethionine-induced cytoplasmic crystalloids in rat parotid acinar cells. Am J Anat 155: 185-200
23. Palade GE (1956) Intracisternal granules in the exocrine cells of the pancreas. J Biophys Biochem Cytol 2: 417-422
24. Patterson CM, Basford KE, Fruger BJ (1976) The effect of fluoride on the immature enamel matrix protein of the rat. Arch Oral Biol 21: 131-132
25. Pfeffer SR, Rothman JE (1987) Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi. Annu Rev Biochem 56: 829-852
26. Pfeifer U (1987) Functional morphology of the lysosomal apparatus. In: Glaumann H, Ballard FJ (eds) Lysosomes: Their role in protein breakdown, Academic Press, New York, pp 3-59
27. Rall L, Pictet R, Githens S, Rutter WJ (1977) Glucocorticoids modulate the in vitro development of the embryonic rat pancreas. J Cell Biol 75: 398-409
28. Reunanen H, Punnonen E-L, Hirsimaki P (1985) Studies on vinblastine-induced autophagocytosis in mouse liver. Histochemistry 83: 513-517
29. Sakai M, Araki N, Ogawa K (1989) Lysosomal movements during heterophagy and autophagy: with special reference to nematolysosome and wrapping lysosome. J Electron Microsc Tech 12: 101-131
30. Schweitzer PA, Taylor SE, Shultz LD (1991) Synthesis of abnormal immunoglobulins by hybridomas from autoimmune "viable motheaten" mutant mice. J Cell Biol 114: 35-43
31. Seglen PO (1987) Regulation of autophagic protein degradation in isolated liver cells. In: Glaumann H, Ballard FJ (eds) Lysosomes: Their Role in Protein Breakdown, Academic Press, New York, pp 371-414
32. Seybold J, Bieger W, Kern HF (1975) Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. II. Inhibition by antimicrotubular agents. Virchows Arch A Pathol Anat Histol 368: 309-327
33. Shinoda H (1975) Effects of long-term administration of fluoride on physico-chemical properties of rat incisor enamel. Calcif Tissue Res 18: 91-100
34. Takuma S, Furui A, Tomoda F, Ogiwara H, Kumamoto Y, Yanagihara T (1983) Ultrastructural studies of disturbances in amelogenesis induced in rat incisor by fluoride and strontium administration. In: Suga S (ed) Mechanism of tooth enamel formation. Quintessence Publishing, Tokyo, pp 259-273
35. Tooze J, Kern HF, Fuller SD, Howell KE (1989) Condensation-sorting events in the rough endoplasmic reticulum of exocrine pancreatic cells. J Cell Biol 109: 35-50
36. Walton RE, Eisenmann DR (1974) Ultrastructural examination of various stages of amelogenesis in the rat following parenteral fluoride administration. Arch Oral Biol 19: 171-182