Lipopolysaccharide induces IL-6 production in respiratory syncytial virus-infected airway epithelial cells through the toll-like receptor 4 signaling pathway

Pediatric Research

Volumn 65, Issue 2, 2009, Pages 156-162

  Xie, Xiao Hong ^a   Law, Helen K W ^b   Wang, Li Jia ^a   Li, Xin ^a   Yang, Xi Qiang ^a   Liu, En Mei ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; RANTES; TOLL LIKE RECEPTOR 4;

ARTICLE; BRONCHIOLITIS; BRONCHUS HYPERREACTIVITY; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RESPIRATORY EPITHELIUM; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SIGNAL TRANSDUCTION; TRACHEA MUCOSA;

ANTIBODIES; CELL LINE; CHEMOKINE CCL5; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; PROTEIN TRANSPORT; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TRACHEA; UP-REGULATION;

EID: 60449086931     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e318191f5c6     Document Type: Article

References (32)

1. Martinez FD 2005 Heterogeneity of the association between lower respiratory illness in infancy and subsequent asthma. Proc Am Thorac Soc 2:157-161
2. Sha Q, Truong-Tran AQ, Plitt JR, Beck LA, Schleimer RP 2004 Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 31:358-364
3. Medzhitov R 2001 Toll-like receptors and innate immunity. Nat Rev Immunol 1:135-145
4. Takeda K, Kaisho T, Akira S 2003 Toll-like receptors. Annu Rev Immunol 21:335-376
5. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW 2000 Pattern recognition receptors TLR4 and CD 14 mediate response to respiratory syncytial virus. Nat Immunol 1:398-401
6. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA 2001 Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3. Nature 413:732-738
7. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S 2002 Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3:196-200
8. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S 2000 A Toll-like receptor recognizes bacterial DNA. Nature 408:740-745, comment 659-660
9. Holtzman MJ, Shornick LP, Orayson MH, Kim EY, Tyner JW, Patel AC, Agapov E, Zhang Y 2004 Hit-and-run effects of paramyxoviruses as a basis for chronic airway disease. Pediatr Infect Dis J 23:S235-S245
10. Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, Si-Tahar M 2005 Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 280:5571-5580
11. Greene CM, Carroll TP, Smith SG, Taggart CC, Devaney J, Griffin S, O'neill SJ, McElvaney NG 2005 TLR-induced inflammation in cystic flbrosis and non-cystic fibrosis airway epithelial cells. J Immunol 174:1638-1646
12. Greene CM, McElvaney NG 2005 Toll-like receptor expression and function in airway epithelial cells. Arch Immunol Ther Exp (Warsz) 53:418-427
13. Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW 2003 Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem 278:53035-53044
14. Proud D 2003 Biology of epithelial cells. In: Adkinson NFJ, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simons FER (eds) Middleton's Allergy: Principles and Practice. Philadelphia: Mosby, pp 373-384
15. Law HK, Cheung CY, Ng HY, Sia SF, Chan YO, Luk W, Nicholls JM, Peiris JS, Lau YL 2005 Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells. Blood 106:2366-2374
16. Stecenko AA, King G, Torii K, Breyer RM, Dworski R, Blackwell TS, Christman JW, Brigham KL 2001 Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation 25:145-155
17. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S 2004 Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303:1526-1529
18. Guillot L, Medjane S, Le-Barillec K, Balloy V, Danel C, Chignard M, Si-Tahar M 2004 Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem 279:2712-2718
19. Yoon JS, Kim HH, Lee Y, Lee JS 2007 Cytokine induction by respiratory syncytial virus and adenovirus in bronchial epithelial cells. Pediatr Pulmonol 42:277-282
20. Rudd BD, Burstein E, Duckett CS, Li X, Lukacs NW 2005 Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. J Virol 79:3350-3357
21. Groskreutz DJ, Monick MM, Powers LS, Yarovinsky TO, Look DC, Hunninghake GW 2006 Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol 176:1733-1740
22. Schleuder J, Hornung V, Finke S, Günthner-Biller M, Marozin S, Brzózka K, Moghim S, Endres S, Hartmann G, Conzelmann KK 2005 Inhibition of toll-like receptor 7- and 9-mediated alpha/beta Interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J Virol 79:5507-5515
23. Gagro A, Tominac M, Krsulović-Hresić V, Baće A, Matić M, Drazenović V, Mlinarić-Galinović G, Kosor E, Gotovac K, Bolanca I, Batinica S, Rabatić S 2004 Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Clin Exp Immunol 135:267-272
24. Schaller M, Hogaboam CM, Lukacs N, Kunkel SL 2006 Respiratory viral infections drive chemokine expression and exacerbate the asthmatic response. J Allergy Clin Immunol 118:295-302
25. Asai K, Hiki N, Mimura Y, Ogawa T, Unou K, Kaminishi M 2001 Gender differences in cytokine secretion by human peripheral blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model. Shock 16:340-343
26. Fokkema SJ, Loos BG, van der Velden U 2003 Monocyte-derived RANTES is intrinsically elevated in periodontal disease while MCP-1 levels are related to inflammation and are inversely correlated with IL-12 levels. Clin Exp Immunol 131:477-483
27. Spann KM, Tran KC, Collins PL 2005 Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3,NF-kappaB, and proinflammatory cytokines. J Virol 79:5353-5362
28. Janssens S, Beyaert R 2003 Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16:637-646
29. Asensi V, Valle E, Meana A, Fierer J, Celada A, Alvarez V, Paz J, Coto E, Carton JA, Maradona JA, Dieguez A, Sarasúa J, Ocaña MG, Arribas JM 2004 In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis. Infect Immun 72:3823-3828
30. + regulatory T cells. Hum Immunol 66:460-468
31. Wan S, Xia C, Morel L 2007 IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+ CD25+ T cell regulatory functions. J Immunol 178:271-279
32. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK 2001 House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 163:322-328