Role of Na+/H+ exchanger NHE3 in nephron function: Micropuncture studies with S3226, an inhibitor of NHE3

American Journal of Physiology - Renal Physiology

Volumn 278, Issue 3 47-3, 2000, Pages

  Vallon, Volker ^a   Schwark, Jan Robert ^b   Richter, Kerstin ^a   Hropot, Max ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b SANOFI   (France)

Author keywords

Loop of Henle; Proximal tubule; Reabsorption; Tubuloglomerular feedback

Indexed keywords

HYDROGEN; SODIUM;

ANIMAL CELL; ARTICLE; CELL CULTURE; FEEDBACK SYSTEM; GLOMERULUS FILTRATION; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; MALE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT;

EID: 0034097514     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.278.3.f375     Document Type: Article

References (24)

1. Ambühl, P. M., M. Amemiya, M. Danczkay, M. Lötscher, B. Kaissling, O. W. Moe, P. A. Preisig, and R. J. Alpern. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 271: F917-F925, 1996.
2. Amemiya, M., J. Loffing, M. Lötscher, B. Kaissling, R. J. Alpern, and O. W. Moe. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb Kidney Int. 48: 1206-1215, 1995.
3. + exchanger gene family (Abstract). J. Am. Soc. Nephrol. 5: 246, 1994.
4. Bell, P. D., and J. Peti-Peterdi. Angiotensin II stimulates macula densa basolateral sodium/hydrogen exchange via type I angiotensin II receptors. J. Am. Soc. Nephrol. 10: S225-S229, 1999.
5. + exchanger isoform of renal brush border. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 265: F736-F742, 1993.
6. + exchanger isoform NHE-1 in rabbit kidney. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 263: F833-F840, 1992.
7. Biemesderfer, D., P. A. Rutherford, T. Nagy, J. H. Pizzonia, A. K. Abu-Alfa, and P. S. Aronson. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney. Am. J. Physiol. Renal Physiol. 273: F289-F299, 1997.
8. + exchanger isoform NHE2 in rat kidney. Am. J. Physiol. Renal Physiol. 275: F379-F386, 1998.
9. Fowler, B. C., Y.-S. Chang, A. Laamarti, M. Higdon, J.-Y. LaPointe, and P. D. Bell. Evidence for apical sodium proton exchange in macula densa cells. Kidney Int. 47: 746-751, 1995.
10. Orlowski, J., R. A. Kandasamy, and G. E. Shull. Molecular cloning of putative members of the Na/H exchanger gene family. J. Biol. Chem. 267: 9331-9339, 1992.
11. Peti-Petredi, J., and P. D. Bell. Regulation of macula densa Na:H exchange by angiotensin II. Kidney Int. 54: 2021-2028, 1998.
12. + antiport in rat proximal tubule NaCl absorption. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 255: F461-F465, 1988.
13. + antiporter in rat proximal tubule bicarbonate absorption. J. Clin. Invest. 80: 970-978, 1987.
14. 1). Am. J. Physiol. Renal Fluid Electrolyte Physiol. 261: F1088-F1094, 1991.
15. +antiporter. Cell 56: 271-280, 1989.
16. + exchanger. Nature Genetics 19: 282-285, 1998.
17. + exchanger isoform (NHE3). J. Biol. Chem. 267: 9340-9346, 1992.
18. + exchanger isoform (NHE2). J. Biol. Chem. 268: 11917-11924, 1993.
19. Scholz, W., U. Albus, L. Counillon, H. Gögelein, H.-J. Lang, W. Linz, A. Weichert, and B. A. Scholkens. Protective effects of HOE 642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischemia and reperfusion. Cardiovasc. Res. 29: 260-268, 1995.
20. + exchanger subtype 3 in various cell types. Pflügers Arch. 436: 797-800, 1998.
21. Vallon, V., R. C. Blantz, and S. C. Thomson. Homeostatic efficiency of tubuloglomerular feedback is reduced in established diabetes mellitus in rats. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 269: F876-F883, 1990.
22. Vallon, V., D. Kirschenmann, L. M. Wead, M. J. Lortie, J. Satriano, R. C. Blantz, and S. C. Thomson. Effect of chronic salt loading on kidney function in early and established diabetes mellitus in rats. J. Lab. Clin. Med. 130: 76-82, 1997.
23. Vallon. V., K. Richter, R. C. Blantz, S. Thomson, and H. Osswald. Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J. Am. Soc. Nephrol. 10: 2569-2576, 1999.
24. Vallon, V., K. Richter, N. Heyne, and H. Osswald. Effect of intratubular application of angiotensin 1-7 on nephron function. Kidney Blood Press. Res. 20: 233-239, 1997.