TCDD-induced homologous recombination: The role of the Ah receptor versus oxidative DNA damage

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 563, Issue 1, 2004, Pages 71-79

  Chan, Clara Y Y ^a   Kim, Perry M ^a   Winn, Louise M ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Ah receptor; Chinese hamster ovary cells; DNA oxidation; Homologous recombination; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 8 HYDROXYDEOXYGUANOSINE; ALPHA NAPHTHOFLAVONE; ALPHA-NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BENZOFLAVONE DERIVATIVE; CARCINOGEN; DNA;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DNA DAMAGE; ELECTROCHEMISTRY; GENE CONVERSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; GENETIC RECOMBINATION; HAMSTER; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; POLLUTANT;

CRICETINAE; CRICETULUS GRISEUS;

ANIMALS; BENZOFLAVONES; CARCINOGENS; CHO CELLS; CRICETINAE; DNA; DNA DAMAGE; ENVIRONMENTAL POLLUTANTS; HUMANS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RECEPTORS, ARYL HYDROCARBON; RECOMBINATION, GENETIC; TETRACHLORODIBENZODIOXIN;

EID: 6044246277     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2004.05.015     Document Type: Article

References (43)

1. Dragan Y.P., Schrenk D. Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion. Food Addit. Contam. 17:2000;289-302
2. Birnbaum L.S., Tuomisto J. Non-carcinogenic effects of TCDD in animals. Food Addit. Contam. 17:2000;275-288
3. Mukerjee D. Health impact of polychlorinated dibenzo-p-dioxins: a critical review. J. Air Waste Manag. Assoc. 48:1998;157-165
4. Sweeney M.H., Mocarelli P. Human health effects after exposure to 2,3,7,8-TCDD. Food Addit. Contam. 17:2000;303-316
5. Galli A., Schiestl R.H. Effects of Salmonella assay negative and positive carcinogens on intrachromosomal recombination in G1-arrested yeast cells. Mutat. Res. 370:1996;209-221
6. Hellgren D. Mutagen-induced recombination in mammalian cells in vitro. Mutat. Res. 284:1992;37-51
7. van den Bosch M., Lohman P.H.M., Pastink A. DNA double-strand break repair by homologous recombination. Biol. Chem. 383:2002;873-892
8. Pierce A.J., Stark J.M., Araujo F.D., Moynahan M.E., Berwick M., Jasin M. Double-strand breaks and tumorigenesis. Trends Cell. Biol. 11:2001;S52-S59
9. Bishop A.J., Schiestl R.H. Homologous recombination as a mechanism for genome rearrangements: environmental and genetic effects. Hum. Mol. Genet. 9:2000;2334-2427
10. Bishop A.J., Schiestl R.H. Homologous recombination as a mechanism of carcinogenesis. Biochim. Biophys. Acta. 1471:2001;M109-M121
11. van Gent D.C., Hoeijmakers J.H., Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2:2001;196-206
12. Gonzalez F.J., Fernandez-Salguero P. The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metab. Dispos. 26:1998;1194-1198
13. Fernandez-Salguero P.M., Hilbert D.M., Rudikoff S., Ward J.M., Gonzalez F.J. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol. Appl. Pharmacol. 140:1996;173-179
14. Okey A.B., Riddick D.S., Harper P.A. The Ah receptor: mediator of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Toxicol. Lett. 70:1994;1-22
15. Poellinger L. Mechanistic aspects - the dioxin (aryl hydrocarbon) receptor. Food Addit. Contam. 17:2000;261-266
16. Hassoun E.A., Al-Ghafri M., Abushaban A. The role of antioxidant enzymes in TCDD-induced oxidative stress in various brain regions of rats after subchronic exposure. Free Radic. Biol. Med. 35:2003;1028-1036
17. Hilscherova K., Blankenship A.L., Nie M., Coady K.K., Upham B.L., Trosko J.E., Giesy J.P. Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 136:2003;29-45
18. Latchoumycandane C., Chitra K.C., Mathur P.P. 2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) induces oxidative stress in the epididymis and epididymal sperm of adult rats. Arch. Toxicol. 77:2003;280-284
19. Jackson S.P. Sensing and repairing DNA double-strand breaks. Carcinogenesis. 23:2002;687-696
20. Schiestl R.H., Aubrecht J., Yap W.Y., Kandikonda S., Sidhom S. Polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin induce intrachromosomal recombination in vitro and in vivo. Cancer Res. 57:1997;4378-4383
21. Nickoloff J.A. Transcription enhances intrachromosomal homologous recombination in mammalian cells. Mol. Cell Biol. 12:1992;5311-5318
22. Ravanat J.L., Gremaud E., Markovic J., Turesky R.J. Detection of 8-oxoguanine in cellular DNA using 2,6-diamino-8-oxopurine as an internal standard for high-performance liquid chromatography with electrochemical detection. Anal. Biochem. 260:1998;30-37
23. Deng W.P., Nickoloff J.A. Preferential repair of UV damage in highly transcribed DNA diminishes UV-induced intrachromosomal recombination in mammalian cells. Mol. Cell Biol. 14:1994;391-399
24. Mann P.C. Selected lesions of dioxin in laboratory rodents. Toxicol. Pathol. 25:1997;72-79
25. Kogevinas M. Studies of cancer in humans. Food Addit. Contam. 17:2000;317-324
26. Grassman J.A., Masten S.A., Walker N.J., Lucier G.W. Animal models of human response to dioxins. Environ. Health Perspect. 106(Suppl 2):1998;761-775
27. Yoshida R., Ogawa Y. Oxidative stress induced by 2,3,7,8- tetrachlorodibenzo-p-dioxin: an application of oxidative stress markers to cancer risk assessment of dioxins. Ind. Health. 38:2000;5-14
28. Bishop A.J., Schiestl R.H. Role of homologous recombination in carcinogenesis. Exp. Mol. Pathol. 74:2003;94-105
29. Gonzalez R., Silva J.M., Dominguez G., Garcia J.M., Martinez G., Vargas J., Provencio M., Espana P., Bonilla F. Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations. Br. J. Cancer. 81:1999;503-509
30. Stohs S.J. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD). Free Radic. Biol. Med. 9:1990;79-90
31. Winn L.M., Kim P.M., Nickoloff J.A. Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity. J. Pharmacol. Exp. Ther. 306:2003;523-527
32. Winn L.M. Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress. Toxicol. Sci. 72:2003;143-149
33. Park J.Y., Shigenaga M.K., Ames B.N. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage. Proc. Natl. Acad. Sci. USA. 93:1996;2322-2327
34. Puga A., Maier A., Medvedovic M. The transcriptional signature of dioxin in human hepatoma HepG2 cells. Biochem. Pharmacol. 60:2000;1129-1142
35. Lee Y.S., Jin D.Q., Park S.H., Han S.Y., Kim H.S., Jeong T.C., Huh K., Kim J.A. 2,3,7,8-Tetrachlorobenzo-p-dioxin inhibits proliferation of SK-N-SH human neuronal cells through decreased production of reactive oxygen species. Free Radic. Res. 36:2002;1283-1289
36. Zeytun A., McKallip R.J., Fisher M., Camacho I., Nagarkatti M., Nagarkatti P.S. Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced gene expression profile in vivo using pathway-specific cDNA arrays. Toxicology. 178:2002;241-260
37. Mimura J., Yamashita K., Nakamura K., Morita M., Takagi T.N., Nakao K., Ema M., Sogawa K., Yasuda M., Katsuki M., Fujii-Kuriyama Y. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells. 2:1997;645-654
38. Shimizu Y., Nakatsuru Y., Ichinose M., Takahashi Y., Kume H., Mimura J., Fujii-Kuriyama Y., Ishikawa T. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc. Natl. Acad. Sci. USA. 97:2000;779-782
39. Gasiewicz T.A., Rucci G. Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8- tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor. Mol. Pharmacol. 40:1991;607-612
40. Blank J.A., Tucker A.N., Sweatlock J., Gasiewicz T.A., Luster M.I. α-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression. Mol. Pharmacol. 32:1987;169-172
41. Merchant M., Arellano L., Safe S. The mechanism of action of alpha-naphthoflavone as an inhibitor of 2,3,7,8-tetrachlorodibenzo-p-dioxin- induced CYP1A1 gene expression. Arch. Biochem. Biophys. 281:1990;84-89
42. Merchant M., Morrison V., Santostefano M., Safe S. Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. Arch. Biochem. Biophys. 298:1992;389-394
43. Kaina B., Fritz G., Coquerelle T. Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines. Environ. Mol. Mutagen. 22:1993;283-292