Direct, DNA pol-γ-independent effects of nucleoside reverse transcriptase inhibitors on mitochondrial bioenergetics

Cardiovascular Toxicology

Volumn 4, Issue 3, 2004, Pages 217-228

  Lund, Kaleb C ^a   Wallace, Kendall B ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

AIDS; Bioenergetics; DNA pol ; HAART; In vitro; Mitochondria; NRTI

Indexed keywords

3' AMINO 3' DEOXYTHYMIDINE; CYTOCHROME C OXIDASE; DIDANOSINE; DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; MITOCHONDRIAL DNA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; ZALCITABINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; BIOENERGY; CARDIOMYOPATHY; COMPETITIVE INHIBITION; DNA REPLICATION; DRUG EFFICACY; FATTY LIVER; HIGH ENERGY PHOSPHATE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LACTIC ACIDOSIS; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MYOPATHY; MITOCHONDRIAL TOXICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PANCREATITIS; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RESPIRATORY CHAIN; REVIEW; SIDE EFFECT;

ANIMALS; CARDIOMYOPATHIES; DNA-DIRECTED DNA POLYMERASE; ELECTRON TRANSPORT COMPLEX III; HEMEPROTEINS; HUMANS; MITOCHONDRIA; NADH DEHYDROGENASE; NUCLEOSIDES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTON-TRANSLOCATING ATPASES; REVERSE TRANSCRIPTASE INHIBITORS; SUCCINATE DEHYDROGENASE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 6044226886     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:4:3:217     Document Type: Review

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