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Volumn 380, Issue 2, 2009, Pages 413-418

The polyamines regulate endothelial cell survival during hypoxic stress through PI3K/AKT and MCL-1

Author keywords

Angiogenesis; Cell death; DFMO; Endothelial cell; Hypoxia; Polyamines

Indexed keywords

ORNITHINE DECARBOXYLASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; POLYAMINE; PROTEIN KINASE B; PROTEIN MCL 1; SMALL INTERFERING RNA;

EID: 60349121139     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.01.097     Document Type: Article
Times cited : (31)

References (34)
  • 1
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 438 (2005) 932-936
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 2
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 3
    • 16644389516 scopus 로고    scopus 로고
    • HIFs, hypoxia, and vascular development
    • Covello K.L., and Simon M.C. HIFs, hypoxia, and vascular development. Curr. Top. Dev. Biol. 62 (2004) 37-54
    • (2004) Curr. Top. Dev. Biol. , vol.62 , pp. 37-54
    • Covello, K.L.1    Simon, M.C.2
  • 4
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • Shiojima I., and Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ. Res. 90 (2002) 1243-1250
    • (2002) Circ. Res. , vol.90 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 5
    • 0034213138 scopus 로고    scopus 로고
    • P38 MAP kinases: beyond the stress response
    • Nebreda A.R., and Porras A. P38 MAP kinases: beyond the stress response. Trends Biochem. Sci. 25 (2000) 257-260
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 257-260
    • Nebreda, A.R.1    Porras, A.2
  • 7
    • 1242272097 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells
    • Wang X., Zhou Y., Kim H.P., Song R., Zarnegar R., Ryter S.W., and Choi A.M. Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. J. Biol. Chem. 279 (2004) 5237-5243
    • (2004) J. Biol. Chem. , vol.279 , pp. 5237-5243
    • Wang, X.1    Zhou, Y.2    Kim, H.P.3    Song, R.4    Zarnegar, R.5    Ryter, S.W.6    Choi, A.M.7
  • 9
    • 34748845732 scopus 로고    scopus 로고
    • Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis
    • Hung S.C., Pochampally R.R., Chen S.C., Hsu S.C., and Prockop D.J. Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis. Stem Cells 25 (2007) 2363-2370
    • (2007) Stem Cells , vol.25 , pp. 2363-2370
    • Hung, S.C.1    Pochampally, R.R.2    Chen, S.C.3    Hsu, S.C.4    Prockop, D.J.5
  • 10
    • 1842559955 scopus 로고    scopus 로고
    • PR39 inhibits apoptosis in hypoxic endothelial cells: role of inhibitor apoptosis protein-2
    • Wu J., Parungo C., Wu G., Kang P.M., Laham R.J., Sellke F.W., Simons M., and Li J. PR39 inhibits apoptosis in hypoxic endothelial cells: role of inhibitor apoptosis protein-2. Circulation 109 (2004) 1660-1667
    • (2004) Circulation , vol.109 , pp. 1660-1667
    • Wu, J.1    Parungo, C.2    Wu, G.3    Kang, P.M.4    Laham, R.J.5    Sellke, F.W.6    Simons, M.7    Li, J.8
  • 12
    • 4944242891 scopus 로고    scopus 로고
    • Polyamines and cancer: old molecules, new understanding
    • Gerner E.W., and Meyskens Jr. F.L. Polyamines and cancer: old molecules, new understanding. Nat. Rev. Cancer 4 (2004) 781-792
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 781-792
    • Gerner, E.W.1    Meyskens Jr., F.L.2
  • 13
    • 33744951504 scopus 로고    scopus 로고
    • Regulation of ornithine decarboxylase
    • Pegg A.E. Regulation of ornithine decarboxylase. J. Biol. Chem. 281 (2006) 14529-14532
    • (2006) J. Biol. Chem. , vol.281 , pp. 14529-14532
    • Pegg, A.E.1
  • 14
    • 34247099261 scopus 로고    scopus 로고
    • Polyamines and neoplastic growth
    • Pegg A.E., and Feith D.J. Polyamines and neoplastic growth. Biochem. Soc. Trans. 35 (2007) 295-299
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 295-299
    • Pegg, A.E.1    Feith, D.J.2
  • 16
    • 2542451727 scopus 로고    scopus 로고
    • Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion
    • Zhang H.M., Rao J.N., Guo X., Liu L., Zou T., Turner D.J., and Wang J.Y. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. J. Biol. Chem. 279 (2004) 22539-22547
    • (2004) J. Biol. Chem. , vol.279 , pp. 22539-22547
    • Zhang, H.M.1    Rao, J.N.2    Guo, X.3    Liu, L.4    Zou, T.5    Turner, D.J.6    Wang, J.Y.7
  • 17
    • 27744529221 scopus 로고    scopus 로고
    • Polyamines and apoptosis
    • Seiler N., and Raul F. Polyamines and apoptosis. J. Cell. Mol. Med. 9 (2005) 623-642
    • (2005) J. Cell. Mol. Med. , vol.9 , pp. 623-642
    • Seiler, N.1    Raul, F.2
  • 18
    • 0032615388 scopus 로고    scopus 로고
    • Identification of laminin alpha1 and beta1 chain peptides active for endothelial cell adhesion, tube formation, and aortic sprouting
    • Malinda K.M., Nomizu M., Chung M., Delgado M., Kuratomi Y., Yamada Y., Kleinman H.K., and Ponce M.L. Identification of laminin alpha1 and beta1 chain peptides active for endothelial cell adhesion, tube formation, and aortic sprouting. FASEB J. 13 (1999) 53-62
    • (1999) FASEB J. , vol.13 , pp. 53-62
    • Malinda, K.M.1    Nomizu, M.2    Chung, M.3    Delgado, M.4    Kuratomi, Y.5    Yamada, Y.6    Kleinman, H.K.7    Ponce, M.L.8
  • 19
    • 0025330360 scopus 로고
    • Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro
    • Takigawa M., Enomoto M., Nishida Y., Pan H.O., Kinoshita A., and Suzuki F. Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. Cancer Res. 50 (1990) 4131-4138
    • (1990) Cancer Res. , vol.50 , pp. 4131-4138
    • Takigawa, M.1    Enomoto, M.2    Nishida, Y.3    Pan, H.O.4    Kinoshita, A.5    Suzuki, F.6
  • 20
    • 0030834335 scopus 로고    scopus 로고
    • Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice
    • Auvinen M., Laine A., Paasinen-Sohns A., Kangas A., Kangas L., Saksela O., Andersson L.C., and Hölttä E. Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice. Cancer Res. 57 (1997) 3016-3025
    • (1997) Cancer Res. , vol.57 , pp. 3016-3025
    • Auvinen, M.1    Laine, A.2    Paasinen-Sohns, A.3    Kangas, A.4    Kangas, L.5    Saksela, O.6    Andersson, L.C.7    Hölttä, E.8
  • 22
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: opposing activities that mediate cell death
    • Youle R.J., and Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9 (2008) 47-59
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 23
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering B.M., and Coffer P.J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376 (1995) 599-602
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 24
    • 0037404666 scopus 로고    scopus 로고
    • Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism
    • Suhara T., Magrané J., Rosen K., Christensen R., Kim H.S., Zheng B., McPhie D.L., Walsh K., and Querfurth H. Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism. Neurobiol. Aging 24 (2003) 437-451
    • (2003) Neurobiol. Aging , vol.24 , pp. 437-451
    • Suhara, T.1    Magrané, J.2    Rosen, K.3    Christensen, R.4    Kim, H.S.5    Zheng, B.6    McPhie, D.L.7    Walsh, K.8    Querfurth, H.9
  • 28
    • 1342322887 scopus 로고    scopus 로고
    • Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2
    • Bhattacharya S., Ray R.M., and Johnson L.R. Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2. Am. J. Physiol. Gastrointest. Liver Physiol. 286 (2004) G479-G490
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.286
    • Bhattacharya, S.1    Ray, R.M.2    Johnson, L.R.3
  • 29
    • 0027480450 scopus 로고
    • MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2
    • Kozopas K.M., Yang T., Buchan H.L., Zhou P., and Craig R.W. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. USA 90 (1993) 3516-3520
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3516-3520
    • Kozopas, K.M.1    Yang, T.2    Buchan, H.L.3    Zhou, P.4    Craig, R.W.5
  • 30
    • 0035825596 scopus 로고    scopus 로고
    • The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6
    • Kuo M.L., Chuang S.E., Lin M.T., and Yang S.Y. The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6. Oncogene 20 (2001) 677-685
    • (2001) Oncogene , vol.20 , pp. 677-685
    • Kuo, M.L.1    Chuang, S.E.2    Lin, M.T.3    Yang, S.Y.4
  • 31
    • 0035898449 scopus 로고    scopus 로고
    • Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation
    • Liu H., Perlman H., Pagliari L.J., and Pope R.M. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. J. Exp. Med. 194 (2001) 113-126
    • (2001) J. Exp. Med. , vol.194 , pp. 113-126
    • Liu, H.1    Perlman, H.2    Pagliari, L.J.3    Pope, R.M.4
  • 32
    • 38349107623 scopus 로고    scopus 로고
    • The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
    • Longo P.G., Laurent L., Gobessi S., Sica S., Leone G., and Efremov D.G. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood 111 (2008) 846-855
    • (2008) Blood , vol.111 , pp. 846-855
    • Longo, P.G.1    Laurent, L.2    Gobessi, S.3    Sica, S.4    Leone, G.5    Efremov, D.G.6
  • 33
    • 0034667393 scopus 로고    scopus 로고
    • Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice
    • Lan L., Trempus C., and Gilmour S.K. Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice. Cancer Res. 60 (2000) 5696-5703
    • (2000) Cancer Res. , vol.60 , pp. 5696-5703
    • Lan, L.1    Trempus, C.2    Gilmour, S.K.3
  • 34
    • 33845504428 scopus 로고    scopus 로고
    • Akt-mediated GSK-3beta inhibition prevents migration of polyamine-depleted intestinal epithelial cells via Rac1
    • Vaidya R.J., Ray R.M., and Johnson L.R. Akt-mediated GSK-3beta inhibition prevents migration of polyamine-depleted intestinal epithelial cells via Rac1. Cell. Mol. Life Sci. 63 (2006) 2871-2879
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 2871-2879
    • Vaidya, R.J.1    Ray, R.M.2    Johnson, L.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.