메뉴 건너뛰기




Volumn 11, Issue 2, 2009, Pages 111-116

Angiopoietin-2: Development of inhibitors for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; ANGIOPOIETIN 2 ANTIBODY; ANGIOPOIETIN RECEPTOR; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

EID: 60349121010     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-009-0017-3     Document Type: Review
Times cited : (107)

References (49)
  • 1
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK: Angiogenesis in cancer and other diseases. Nature 2000, 407:249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 2
    • 34547103275 scopus 로고    scopus 로고
    • Angiopoietin: A TIE(d) balance in tumor angiogenesis
    • Shim WS,AHo IA, Wong PE: Angiopoietin: a TIE(d) balance in tumor angiogenesis. Mol Cancer Res 2007, 5:655-665.
    • (2007) Mol Cancer Res , vol.5 , pp. 655-665
    • Shim, W.S.1    Ho, I.A.2    Wong, P.E.3
  • 3
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    • [see comments]
    • Davis S, Aldrich TH, Jones PF, et al.: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [see comments]. Cell 1996, 87:1161-1169.
    • (1996) Cell , vol.87 , pp. 1161-1169
    • Davis, S.1    Aldrich, T.H.2    Jones, P.F.3
  • 4
    • 0030480322 scopus 로고    scopus 로고
    • Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    • [see comments]
    • Suri C, Jones PF, Patan S, et al.: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [see comments]. Cell 1996, 87:1171-1180.
    • (1996) Cell , vol.87 , pp. 1171-1180
    • Suri, C.1    Jones, P.F.2    Patan, S.3
  • 5
    • 0032538385 scopus 로고    scopus 로고
    • Increased vascularization in mice overexpressing angiopoietin-1
    • Suri C, McClain J, Thurston G, et al.: Increased vascularization in mice overexpressing angiopoietin-1. Science 1998, 282:468-471.
    • (1998) Science , vol.282 , pp. 468-471
    • Suri, C.1    McClain, J.2    Thurston, G.3
  • 6
    • 0033601357 scopus 로고    scopus 로고
    • Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    • Thurston G, Suri C, Smith K, et al.: Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999, 286:2511-2514.
    • (1999) Science , vol.286 , pp. 2511-2514
    • Thurston, G.1    Suri, C.2    Smith, K.3
  • 7
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • [see comments]
    • Maisonpierre PC, Suri C, Jones PF, et al.: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis [see comments]. Science 1997, 277:55-60.
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 8
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J, Maisonpierre PC, Compton D, et al.: Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999, 284:1994-1998.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3
  • 9
    • 0037143737 scopus 로고    scopus 로고
    • Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo
    • Lobov IB, Brooks PC, Lang RA: Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A 2002, 99:11205-11210.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11205-11210
    • Lobov, I.B.1    Brooks, P.C.2    Lang, R.A.3
  • 10
    • 18644382318 scopus 로고    scopus 로고
    • Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1
    • Gale NW, Thurston G, Hackett SF, et al.: Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell 2002, 3:411-423.
    • (2002) Dev Cell , vol.3 , pp. 411-423
    • Gale, N.W.1    Thurston, G.2    Hackett, S.F.3
  • 11
    • 46049111407 scopus 로고    scopus 로고
    • Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice
    • Dellinger M, Hunter R, Bernas M, et al.: Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol 2008, 319:309-320.
    • (2008) Dev Biol , vol.319 , pp. 309-320
    • Dellinger, M.1    Hunter, R.2    Bernas, M.3
  • 12
    • 38349080865 scopus 로고    scopus 로고
    • Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch
    • Rao S, Lobov IB, Vallance JE, et al.: Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development 2007, 134:4449-4458.
    • (2007) Development , vol.134 , pp. 4449-4458
    • Rao, S.1    Lobov, I.B.2    Vallance, J.E.3
  • 13
    • 0035318510 scopus 로고    scopus 로고
    • Tie receptors: New modulators of angiogenic and lymphangiogenic responses
    • Jones N, Nljin K, Dumont DJ, et al.: Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat Rev Mol Cell Biol 2001, 2:257-267.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 257-267
    • Jones, N.1    Iljin, K.2    Dumont, D.J.3
  • 14
    • 14944377120 scopus 로고    scopus 로고
    • The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism
    • Scharpfenecker M, Fiedler U, Reiss Y, et al.: The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci 2005, 118:771-780.
    • (2005) J Cell Sci , vol.118 , pp. 771-780
    • Scharpfenecker, M.1    Fiedler, U.2    Reiss, Y.3
  • 15
    • 4644286776 scopus 로고    scopus 로고
    • The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors
    • Hildbrand P, Cirulli V, Prinsen RC, et al.: The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors. Blood 2004, 104:2010-2019.
    • (2004) Blood , vol.104 , pp. 2010-2019
    • Hildbrand, P.1    Cirulli, V.2    Prinsen, R.C.3
  • 16
    • 13544249614 scopus 로고    scopus 로고
    • Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses
    • Lemieux C, Maliba R, Favier J, et al.: Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood 2005, 105:1523-1530.
    • (2005) Blood , vol.105 , pp. 1523-1530
    • Lemieux, C.1    Maliba, R.2    Favier, J.3
  • 17
    • 4544290590 scopus 로고    scopus 로고
    • Angiopoietins in tumours: The angiogenic switch
    • Tait CR, Jones PF: ATgiopoietins in tumours: the angiogenic switch. J Pathol 2004, 204:1-10.
    • (2004) J Pathol , vol.204 , pp. 1-10
    • Tait, C.R.1    Jones, P.F.2
  • 18
    • 34248582785 scopus 로고    scopus 로고
    • Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth
    • Cao Y, Sonveaux P, Liu S, et al.: Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. Cancer Res 2007, 67:3835-3844.
    • (2007) Cancer Res , vol.67 , pp. 3835-3844
    • Cao, Y.1    Sonveaux, P.2    Liu, S.3
  • 19
    • 33744829739 scopus 로고    scopus 로고
    • Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth
    • Lee OH, Fueyo J, Xu J, et al.: Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth. Neoplasia 2006, 8:419-428.
    • (2006) Neoplasia , vol.8 , pp. 419-428
    • Lee, O.H.1    Fueyo, J.2    Xu, J.3
  • 21
    • 34249297624 scopus 로고    scopus 로고
    • Angiopoietin-2 stimulates breast cancer metastasis through the {alpha}5{beta}1 integrin-mediated pathway
    • Imanishi Y, Hu B, Jarzynka MJ, et al.: Angiopoietin-2 stimulates breast cancer metastasis through the {alpha}5{beta}1 integrin-mediated pathway. Cancer Res 2007, 67:4254-4263.
    • (2007) Cancer Res , vol.67 , pp. 4254-4263
    • Imanishi, Y.1    Hu, B.2    Jarzynka, M.J.3
  • 22
    • 14644399862 scopus 로고    scopus 로고
    • Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma
    • Guo P, Imanishi Y, Cackowski FC, et al.: Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma. Am J Pathol 2005, 166:877-890.
    • (2005) Am J Pathol , vol.166 , pp. 877-890
    • Guo, P.1    Imanishi, Y.2    Cackowski, F.C.3
  • 23
    • 0041806539 scopus 로고    scopus 로고
    • Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2
    • Hu B, Guo P, Fang Q, et al.: Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc Natl Acad Sci U S A 2003, 100:8904-8909.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8904-8909
    • Hu, B.1    Guo, P.2    Fang, Q.3
  • 24
    • 33344477298 scopus 로고    scopus 로고
    • Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling
    • Eklund L, Olsen BR: Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp Cell Res 2006, 312:630-641.
    • (2006) Exp Cell Res , vol.312 , pp. 630-641
    • Eklund, L.1    Olsen, B.R.2
  • 25
    • 23044508993 scopus 로고    scopus 로고
    • Angiopoietin 1 is mitogenic for cultured endothelial cells
    • Kanda S, Miyata Y, Mochizuki Y, et al.: Angiopoietin 1 is mitogenic for cultured endothelial cells. Cancer Res 2005, 65:6820-6827.
    • (2005) Cancer Res , vol.65 , pp. 6820-6827
    • Kanda, S.1    Miyata, Y.2    Mochizuki, Y.3
  • 26
    • 22144447473 scopus 로고    scopus 로고
    • Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow
    • Cho CH, Kim KE, Byun J, et al.: Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow. Circ Res 2005, 97:86-94.
    • (2005) Circ Res , vol.97 , pp. 86-94
    • Cho, C.H.1    Kim, K.E.2    Byun, J.3
  • 27
    • 33749368374 scopus 로고    scopus 로고
    • Signaling and regulation of endothelial cell survival by angiopoietin-2
    • Harfouche R, Hussain SN: Signaling and regulation of endothelial cell survival by angiopoietin-2. Am J Physiol 2006, 291:H1635-H1645.
    • (2006) Am J Physiol , vol.291
    • Harfouche, R.1    Hussain, S.N.2
  • 28
    • 39749174416 scopus 로고    scopus 로고
    • Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in gliomas
    • Lee OH, Xu J, Fueyo J, et al.: Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in gliomas. Oncogene 2008, 27:1310-1314.
    • (2008) Oncogene , vol.27 , pp. 1310-1314
    • Lee, O.H.1    Xu, J.2    Fueyo, J.3
  • 29
    • 0034648793 scopus 로고    scopus 로고
    • Vascularspecific growth factors and blood vessel formation
    • Yancopoulos GD, Davis S, Gale NW, et al.: Vascularspecific growth factors and blood vessel formation. Nature 2000, 407:242-248.
    • (2000) Nature , vol.407 , pp. 242-248
    • Yancopoulos, G.D.1    Davis, S.2    Gale, N.W.3
  • 30
    • 0035854835 scopus 로고    scopus 로고
    • Direct cell adhesion to the angiopoietins mediated by integrins
    • Carlson TR, Feng Y, Maisonpierre PC, et al.: Direct cell adhesion to the angiopoietins mediated by integrins. J Biol Chem 2001, 276:26516-26525.
    • (2001) J Biol Chem , vol.276 , pp. 26516-26525
    • Carlson, T.R.1    Feng, Y.2    Maisonpierre, P.C.3
  • 31
    • 23844544130 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins
    • Dallabrida SM, Ismail N, Oberle JR, et al.: Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circ Res 2005, 96:e8-e24.
    • (2005) Circ Res , vol.96
    • Dallabrida, S.M.1    Ismail, N.2    Oberle, J.R.3
  • 32
    • 0037219502 scopus 로고    scopus 로고
    • Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
    • Davis S, Papadopoulos N, Aldrich TH, et al.: Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. Nat Struct Biol 2003, 10:38-44.
    • (2003) Nat Struct Biol , vol.10 , pp. 38-44
    • Davis, S.1    Papadopoulos, N.2    Aldrich, T.H.3
  • 33
    • 20444446335 scopus 로고    scopus 로고
    • Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization
    • Weber CC, Cai H, Ehrbar M, et al.: Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization. J Biol Chem 2005, 280:22445-22453.
    • (2005) J Biol Chem , vol.280 , pp. 22445-22453
    • Weber, C.C.1    Cai, H.2    Ehrbar, M.3
  • 34
    • 24944468632 scopus 로고    scopus 로고
    • Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
    • Cascone I, Napione L, Maniero F, et al.: Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1. J Cell Biol 2005, 170:993-1004.
    • (2005) J Cell Biol , vol.170 , pp. 993-1004
    • Cascone, I.1    Napione, L.2    Maniero, F.3
  • 35
    • 31544447172 scopus 로고    scopus 로고
    • Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the {alpha}v{beta}1 integrin and focal adhesion kinase signaling pathway
    • Hu B, Jarzynka MJ, Guo P, et al.: Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the {alpha}v{beta}1 integrin and focal adhesion kinase signaling pathway. Cancer Res 2006, 66:775-783.
    • (2006) Cancer Res , vol.66 , pp. 775-783
    • Hu, B.1    Jarzynka, M.J.2    Guo, P.3
  • 36
    • 0037023721 scopus 로고    scopus 로고
    • beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PGM/versican
    • Wu Y, Chen L, Zheng PS, et al.: Beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PGM/versican. J Biol Chem 2002, 277:12294-12301.
    • (2002) J Biol Chem , vol.277 , pp. 12294-12301
    • Wu, Y.1    Chen, L.2    Zheng, P.S.3
  • 37
    • 33644851212 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells
    • Phelps ED, Updike DL, Bullen EC, et al.: Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol 2006, 290:C352-C361.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Phelps, E.D.1    Updike, D.L.2    Bullen, E.C.3
  • 38
    • 0034673554 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells
    • Kim I, Kim JH, Ryu YS, et al.: Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells. Biochem Biophys Res Commun 2000, 269:361-365.
    • (2000) Biochem Biophys Res Commun , vol.269 , pp. 361-365
    • Kim, I.1    Kim, J.H.2    Ryu, Y.S.3
  • 39
    • 0036493752 scopus 로고    scopus 로고
    • Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells
    • Huang YQ, Li JJ, Hu L, et al.: Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells. Blood 2002, 99:1646-1650.
    • (2002) Blood , vol.99 , pp. 1646-1650
    • Huang, Y.Q.1    Li, J.J.2    Hu, L.3
  • 40
    • 0036168389 scopus 로고    scopus 로고
    • Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen
    • Ye F, Florian M, Magder SA, et al.: Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Steroids 2002, 67:305-310.
    • (2002) Steroids , vol.67 , pp. 305-310
    • Ye, F.1    Florian, M.2    Magder, S.A.3
  • 41
    • 0035896606 scopus 로고    scopus 로고
    • Leptin induces angiopoietin-2 expression in adipose tissues
    • Cohen B, Barkan D, Levy Y, et al.: Leptin induces angiopoietin-2 expression in adipose tissues. J Biol Chem 2001, 276:7697-7700.
    • (2001) J Biol Chem , vol.276 , pp. 7697-7700
    • Cohen, B.1    Barkan, D.2    Levy, Y.3
  • 42
    • 35649026775 scopus 로고    scopus 로고
    • High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A
    • Yao D, Taguchi T, Matsumura T, et al.: High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem 2007, 282:31038-31045.
    • (2007) J Biol Chem , vol.282 , pp. 31038-31045
    • Yao, D.1    Taguchi, T.2    Matsumura, T.3
  • 43
    • 24644519938 scopus 로고    scopus 로고
    • Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
    • Potente M, Urbich C, Sasaki K, et al.: Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest 2005, 115:2382-2392.
    • (2005) J Clin Invest , vol.115 , pp. 2382-2392
    • Potente, M.1    Urbich, C.2    Sasaki, K.3
  • 44
    • 48249143579 scopus 로고    scopus 로고
    • FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
    • Xue Y, Cao R, Nilsson D, et al.: FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci U S A 2008, 105:10167-10172.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10167-10172
    • Xue, Y.1    Cao, R.2    Nilsson, D.3
  • 45
    • 34548128334 scopus 로고    scopus 로고
    • Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia
    • Schliemann C, Bieker R, Thoennissen N, et al.: Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia. Leukemia 2007, 21:1901-1906.
    • (2007) Leukemia , vol.21 , pp. 1901-1906
    • Schliemann, C.1    Bieker, R.2    Thoennissen, N.3
  • 46
    • 35448947787 scopus 로고    scopus 로고
    • Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma
    • Scholz A, Rehm VA, Rieke S, et al.: Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma. Am J Gastroenterol 2007, 102:2471-2481.
    • (2007) Am J Gastroenterol , vol.102 , pp. 2471-2481
    • Scholz, A.1    Rehm, V.A.2    Rieke, S.3
  • 47
    • 34447525629 scopus 로고    scopus 로고
    • Serum angiopoietin-2 as a clinical marker for lung cancer
    • Park JH, Park KJ, Kim YS, et al.: Serum angiopoietin-2 as a clinical marker for lung cancer. Chest 2007, 132:200-206.
    • (2007) Chest , vol.132 , pp. 200-206
    • Park, J.H.1    Park, K.J.2    Kim, Y.S.3
  • 48
    • 0037966956 scopus 로고    scopus 로고
    • Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2
    • White RR, Shan S, Rusconi CP, et al.: Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. Proc Natl Acad Sci U S A 2003, 100:5028-5033.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5028-5033
    • White, R.R.1    Shan, S.2    Rusconi, C.P.3
  • 49
    • 7944220649 scopus 로고    scopus 로고
    • Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    • Oliner J, Min H, Leal J, et al.: Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 2004, 6:507-516.
    • (2004) Cancer Cell , vol.6 , pp. 507-516
    • Oliner, J.1    Min, H.2    Leal, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.