Effects of a phytosterol-enriched dairy product on lipids, sterols and 8-isoprostane in hypercholesterolemic patients: A multicenter Italian study

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 19, Issue 2, 2009, Pages 84-90

  Mannarino, E ^a   Pirro, M ^a   Cortese, C ^b   Lupattelli, G ^a   Siepi, D ^a   Mezzetti, A ^c   Bertolini, S ^d   Parillo, M ^e   Fellin, R ^f   Pujia, A ^g   Averna, M ^h   Nicolle, C ⁱ   Notarbartolo, A ^h  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e Azienda Ospedaliera di Caserta   (Italy)

^f UNIVERSITY OF FERRARA   (Italy)

^g UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^h UNIVERSITY OF PALERMO   (Italy)

ⁱ DANONE RESEARCH   (France)

Author keywords

Hypercholesterolemia; Isoprostanes; Phytosterols

Indexed keywords

8 EPI PROSTAGLANDIN F2ALPHA; 8-EPI-PROSTAGLANDIN F2ALPHA; ANTIOXIDANT; CHOLESTEROL; DRUG DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT; PHYTOSTEROL; PROSTAGLANDIN F2 ALPHA; STEROL;

ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAIRY PRODUCT; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; ITALY; MALE; MIDDLE AGED; MULTICENTER STUDY; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; TIME; TREATMENT OUTCOME;

ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CHOLESTEROL; CULTURED MILK PRODUCTS; DINOPROST; DOUBLE-BLIND METHOD; FEMALE; FOOD, FORTIFIED; HUMANS; HYPERCHOLESTEROLEMIA; ITALY; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHYTOSTEROLS; STEROLS; TIME FACTORS; TREATMENT OUTCOME;

EID: 60349103903     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2008.03.012     Document Type: Article

References (39)

1. Shepherd J., Cobbe S.M., Ford I., Isles C.G., Lorimer A.R., MacFarlane P.W., et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 333 (1995) 1301-1307
2. Downs J.R., Clearfield M., Weis S., Whitney E., Shapiro D.R., Beere P.A., et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 279 (1998) 1615-1622
3. Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344 (1994) 1383-1389
4. Sacks F.M., Pfeffer M.A., Moye L.A., Rouleau J.L., Rutherford J.D., Cole T.G., et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med 335 (1996) 1001-1009
5. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 339 (1998) 1349-1357
6. Peterson D.W., Nichols C.W., and Schneour E.W. Some relationships among dietary sterols, plasma and liver cholesterol levels and atherosclerosis in chicks. J Nutr 47 (1952) 57-65
7. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Ecutive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 285 (2001) 2486-2497
8. Cleghorn C.L., Skeaff C.M., Mann J., and Chisholm A. Plant sterol-enriched spread enhances the cholesterol-lowering potential of a fat-reduced diet. Eur J Clin Nutr 57 (2003) 170-176
9. Miettinen T.A., Strandberg T.E., and Gylling H. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. Arterioscler Thromb Vasc Biol 20 (2000) 1340-1346
10. Takeshita M., Katsuragi Y., Kusuhara M., Higashi K., Miyajima E., Mizuno K., et al. Phytosterols dissolved in diacylglycerol oil reinforce the cholesterol-lowering effect of low-dose pravastatin treatment. Nutr Metab Cardiovasc Dis (2007) [Epub ahead of print]
11. Blair S.N., Capuzzi D.M., Gottlieb S.O., Nguyen T., Morgan J.M., and Cater N.B. Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy. Am J Cardiol 86 (2000) 46-52
12. Neil H.A., Meijer G.W., and Roe L.S. Randomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spread. Atherosclerosis 156 (2001) 329-337
13. Gylling H., and Miettinen T.A. Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. Atherosclerosis 160 (2002) 477-481
14. Ostlund Jr. R.E. Phytosterols, cholesterol absorption and healthy diets. Lipids 42 (2007) 41-45
15. Lea L.J., and Hepburn P.A. Safety evaluation of phytosterol-esters. Part 9: results of a European post-launch monitoring programme. Food Chem Toxicol 44 (2006) 1213-1222
16. Musiek E.S., Yin H., Milne G.L., and Morrow J.D. Recent advances in the biochemistry and clinical relevance of the isoprostane pathway. Lipids 40 (2005) 987-994
17. Cracowski J.L., Devillier P., Durand T., Stanke-Labesque F., and Bessard G. Vascular biology of the isoprostanes. J Vasc Res 38 (2001) 93-103
18. Ahmida H.S.M., Bertucci P., Franzò L., Massoud R., Cortese C., Lala A., et al. Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). J Chromatogr B Analyt Technol Biomed Life Sci 842 (2006) 43-47
19. Peterson D.W. Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks. Proc Soc Exp Biol Med 78 (1951) 143-147
20. Thompson G., and Grundy M.S. History and development of plant sterols and stanol esters for cholesterol lowering purposes. Am J Cardiol 96 Suppl (2005) 3D-9D
21. Clifton P.M., Noakes M., Sullivan D., Erichsen N., Ross D., Annison G., et al. Cholesterol lowering effects of plant sterol esters differ in milk, yoghurt, bread and cereals. Eur J Clin Nutr 58 (2004) 503-509
22. Devaraj S., Jialal I., and Vega Lopez S. Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscl Thromb Vasc Biol 24 (2004) 25-28
23. Law M. Plant sterol and stanol margarines and health. BMJ 320 (2000) 861-864
24. Mensink R.P., Ebbing S., Lindhout M., Plat J., and van Heugten M.M. Effects of plant stanol esters supplied in low fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis 160 (2002) 205-213
25. Doornbos A.M., Meynen E.M., Duchateau G.S., van der Knaap H.C., and Trautwein E.A. Intake occasion affects the serum cholesterol lowering of a plant sterol enriched single dose yoghurt drink in mildly hypercholesterolemic subjects. Eur J Clin Nutr 60 (2006) 325-333
26. Jauhaiainen T., Salo P., Niittynen L., Poussa T., and Korpela R. Effects of low fat hard cheese enriched with plant stanol esters on serum lipids and apolipoproteins B in mildly hypercholesterolemic subjects. Eur J Clin Nutr 60 (2006) 1253-1257
27. Jones P.J., Vanstone C.A., Raeini-Sarjaz M., and St-Onge M.P. Phytosterols in low- and nonfat beverages as part of a controlled diet fail to lower plasma lipid levels. J Lipid Res 44 (2003) 1713-1719
28. Hallikainen M.A., Sarkkinen E.S., Gylling H., Erkkila A.T., and Uusitupa M.I. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr 54 (2000) 715-725
29. Hansel B., Nicolle C., Lalanne F., Tondu F., Lassel T., Donazzolo Y., et al. Effect of low fat fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercheolsetrolemia. Am J Clin Nutr 86 (2007) 790-796
30. Seppo L., Jauhiainen T., Nevala R., Poussa T., and Korpela R. Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol. Eur J Nutr 46 (2007) 111-117
31. Bosner M.S., Lange L.G., Stenson W.F., and Ostlund Jr. R.E. Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry. J Lipid Res 40 (1999) 302-308
32. De Jong A., Plat J., and Menskink R.P. Metabolic effects of plant sterols and stanols. J Nutr Biochem 14 (2003) 362-369
33. Spilburg C.A., Goldberg A.C., Mc Gill J.B., Stenson W.F., Racette S.B., Bateman J., et al. Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol. J Am Diet Assoc 103 (2003) 577-581
34. Plat J., and Menskink R.P. Increased intestinal ABCA1 expression contributes to the decrease in cholesterol absorption after plant stanol consumption. FASEB J 16 (2002) 1248-1253
35. Panagiotakos D.B., Pitsavos C., Skoumas J., Chrysohoou C., Toutouza M., Stefanadis C.I., et al. Importance of LDL/HDL cholesterol ratio as a predictor for coronary heart disease events in patients with heterozygous familial hypercholesterolaemia: a 15-year follow-up (1987-2002). Curr Med Res Opin 19 (2003) 89-94
36. Ortega R.M., Palencia A., and Lopez-Sobaler A.M. Improvement of cholesterol levels and reduction of cardiovascular risk via the consumption of phytosterols. Br J Nutr 96 Suppl 1 (2006) S89-S93
37. Chehne F., Oguogho A., Lupattelli G., Budinsky A.C., Palumbo B., and Sinzinger H. Increase of isoprostane 8-epi-PGF(2alpha)after restarting smoking. Prostaglandins Leukot Essent Fatty Acids 64 (2001) 307-310
38. Sudhop T., Gottwald B.M., and von Bergmann K. Serum plant sterols as a potential risk factor for coronary heart disease. Metabolism 51 (2002) 1519-1521
39. Plana N., Nicolle C., Ferre R., Camps J., Cos R., Villoria J., et al. on behalf of the DANACOL group. Plant sterol-enriched fermented milk enhances the attainment of LDL-cholesterol goal in hypercholesterolemic subjects. Eur J Nutr 47 (2008) 32-39