The altered expression of inflammation-related molecules and secretion of IL-6 and IL-8 by HUVEC from newborns with maternal inactive systemic lupus erythematosus is modified by estrogens

Lupus

Volumn 17, Issue 12, 2008, Pages 1086-1095

  Rodriguez, Emma ^a   Guevara, J ^b   Paez, A ^a   Zapata, E ^a   Collados, M T ^c   Fortoul, T I ^b   Lopez Marure, R ^a   Masso, F ^a   Montano L F ^b  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

Author keywords

Adhesion molecules; Endothelial cells; Estradiol; Inflammation; Lupus

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ESTRADIOL; ESTROGEN DERIVATIVE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEPARIN; HYDROXYCHLOROQUINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; PREDNISONE; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSKELETON; DISEASE ACTIVITY; DISEASE COURSE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; NEWBORN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SYSTEMIC LUPUS ERYTHEMATOSUS; UMBILICAL VEIN; UPREGULATION; VASCULAR ENDOTHELIUM;

ADULT; CELLS, CULTURED; CYTOSKELETON; E-SELECTIN; ENDOTHELIAL CELLS; ESTROGENS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HEAT-SHOCK PROTEINS; HUMANS; INFANT, NEWBORN; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; INTERLEUKIN-8; LUPUS ERYTHEMATOSUS, SYSTEMIC; PREGNANCY; PREGNANCY COMPLICATIONS; TOLL-LIKE RECEPTOR 9; UMBILICAL VEINS; YOUNG ADULT;

EID: 60349103471     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203308093827     Document Type: Article

References (68)

1. Costedoat-Chalumeau, N, Amoura, Z, Lupoglazoff, JM, et al. Outcome of pregnancies in patients with anti-SSA/Ro antibodies: A study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control group. Arthritis Rheum 2004; 50: 3187-3194.
2. Merbl, Y, Zucker-Moledano, M, Qintana, FJ, Cohen, IR. Newborn humans manifest autoantibodies to defined self molecules detected by antigen mycroarray informatics. J Clin Invest 2007; 117: 712-718.
3. Lahita, RG. The effects of sex hormones on the immune system in pregnancy. Am J Reprod Immunol 1992; 28: 136-137.
4. Doria, A,Iaccarino, L, Sarzi-Puttini, P., et al. Estrogens in pregnancy and systemic lupus erythematosus. Ann N Y Acad Sci 2006; 1069: 247-257.
5. Gao, H, Lianag, M, Bergdahl A. Estrogens attenuates vascular expression of inflammation associated genes and adhesion of monocytes to endothelial cells. Inflamm Res 2006; 55: 349-353.
6. Xing, D, Feng, W, Miller, AP, et al. S. Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation. Am J Physiol Heart Circ Physiol 2007; 292: H2607-H2612.
7. Kaplanski, G, Cacoub, P, Farnarier, C, et al. Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: correlations with the severity of thrombosis. Arthritis Rheum 2000; 43: 55-64.
8. Lakasing, L, Campa, J, Parmar, K, Poston, R, Hunt, BJ, Poston, L. Normal expression of cell adhesion molecules in placentae from women with systemic lupus erythematosus and the phospholipids syndrome. Placenta 2000; 21: 142-149.
9. Yazici, ZA, Raschi, E, Patel, A, et al. Human mono lonal anti-endothelial cell IgG-derived from a systemic lupus erythematosus patient binds and activates human endothelium in vitro. Int Immunol 2001; 13: 349-357.
10. Lai, KN, Leung, JC, Lai, KB, Lai, CK. Effect of anti-DNA autoantibodies on the gene expression of interleukin 8, transforming growth factor-beta, and nitric oxide synthase in cultured cells. Scand J Rheumatol 1997; 26: 461-467.
11. Salotra, P, Chauhan, D, Ralhan, R, Bhatnagar, R. Tumour necrosis factor-alpha induces preferential expression of stress proteins in virulent promastigotes of Leishmania donovani. Immunol lett 1995; 44: 1-5.
12. Stephanou, A, Isenberg, DA, Akira, S, Kishimoto, T, Latchman, DS. The nuclear factor interleukin-6 (NF-IL6) and signal transducer and activator of transcription-3 (STAT-3) signalling pathways co-operate to mediate the activation of the hsp90beta gene by. Biochem J 1998; 330: 189-195.
13. Lit, LC, Wong, CK, Li, EK, Tam, LS, Lam, CW, Lo, YM. Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease ctivity in patients with systemic lupus erythematosus. J Rheumatol 2007; 34: 89-96.
14. Njemimi, R, Lambert, M, Demanet, C, Mets, T. Elevated serum heat-shock protein 70 levels in patients with acute infection: Use of an optimized enzyme-linked immunosorbent assaycytokine profile, metalloprotease-9 activity and hormonal status in pregnant rheumatoid arthritis and systemic lupus erythematosus patients. Scand J Immunol 2003; 58: 664-669.
15. Muñoz-Valle, JF, Vázquez-Del Mercado, M, García-Iglesias, T, et al. T(H)1/T(H)2 cytokine profile, metalloprotease-9 activity and hormonal status in pregnant rheumatoid arthritis and systemic lupus erythematosus patients. Clin Exp Immunol 2003; 131: 377-384.
16. Viallard, JF, Pellegrin, JL, Ranchin, V, et al. Th1 (IL-2, interferon-gamma (IFN-gamma)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE). Clin Exp Immunol 1999; 115: 189-195.
17. Snapper, CM, Mond, JJ. Towards a comprehensive view of immunoglobulin class switching. Immunol Today 1993; 14: 15-17.
18. Parke A. Drug exposure, pregnancy outcome and fetal and childhood development occurring in the offspring of mothers with systemic lupus erythematosus and other chronic autoimmune diseases. Lupus 2006; 15: 808-813.
19. Scott JR. Risks to the children born to mothers with autoimmune diseases. Lupus 2002; 11: 655-660.
20. Sato, H, Miida, T, Wada, Y, et al. Atherosclerosis is accelerated in patients with long-term well-controlled Systemic Lupus Erythematosus (SLE). Clin Chim Acta 2007; 385: 35-42.
21. Crispin, JC, Kyttaris, VC, Juanq, YT, Tsokos, GC. How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol 2008; 29: 110-115.
22. Daïkha-Dahmane, F, Bault, JP, Molina-Gomes, D, Hillion, D, Ville, Y. Lupus erythematosus proliferative glomerulonephritis in fetus. Lupus 2005; 14: 326-327.
23. Vitali, C, Bencivelli, W, Isenberg, DA, et al. Disease activity in systemic lupus erythematosus: Report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of the variables indicative of disease activity and their use in the development of an activity score. Clin Exp Rheumatol 1992; 10: 541-547.
24. Ruiz-Irastorza, G, Khamashta, MA. Evaluation of systemic lupus erythematosus activity during pregnancy. Lupus 2004; 13: 679-682.
25. Zapata, E, Ventura, JL, De la Cruz, K, et al. Dehydroepiandrosterone inhibits the proliferation of HUVEC by enhancing the expression of p53 and p21, restricting the phosphorylation of RB, and is androgen- and estrogen-receptor independent. FEBS J 2005; 272: 1343-1353.
26. Doria, A, Ghirardello, A, Iaccarino L, et al. Pregnancy, cytokines, and disease activity in systemic lupus erythematosus. Arthritis Rheum 2004; 51: 989-995.
27. Cutolo, M, Capellino, S, Sulli A, et al. Estrogens and autoimmune diseases. Ann N Y Acad Sci 2006; 1089: 538-547.
28. Zhu, L, Yang, X, Chen, W, et al. Decreased expressions of the TNF-alpha signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus. Clin Rheumatol 2007; 26: 1481-1489.
29. Ling, S, Zhou, L, Li, H, et al. Effects of 17β-estradiol on growth and apoptosis in human vascular endothelial cells: Influence of mechanical strain and tumor necrosis factor-α. Steroids 2006; 71: 799-808.
30. Fanzo, JC, Yang, W, Jang, SY, et al. Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. J Clin Invest 2006; 116: 703-714.
31. Lewis, MJ, D'Cruz, D. Adhesion molecules, mycophenolate mofetil and systemic lupus erythematosus. Lupus 2005; 14(Suppl. 1): S17-S26.
32. Carvalho, D, Savage, COS, Isenberg, D, Pearson, JD. IgG anti-endothelial cell autoantibodies from patients with systemic lupus erythematosus or systemic vasculitis stimulate the release of two endothelial-cell derived mediators, which enhance adhesion molecule expression and leukocyte adhesion in an autocrine manner. Arthritis Rheum 1999; 42: 631-640.
33. Carvalho, D, Savage, COS, Black, CM, Pearson, JD. IgG anti-endothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro: Induction of adhesion molecule expression and involvement of endothelium-derived cytokines. J Clin Invest 1996; 97: 111-119.
34. Del Papa, N, Guidali, L, Sironi, M, et al. Anti-endothelial cell IgG autoantibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion. Arthritis Rheum 1996; 39: 758-766.
35. Pierangelli, SS, Colden-Stanfield, M, Liu, X, Barker, JH, Anderson, GL, Harris, EN. Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 1999; 99: 1997-2002.
36. Meroni, PL, Borghi, MO, Raschi, E,. Inflammatory response and the endothelium. Thromb Res 2004; 114: 329-334.
37. Bernot, D, Peiretti, F, Canault, M, Juhan-Vague, I, Nalbone G. Upregulation of TNF-a-induced ICAM-1 surface expression by adenylate cyclase-dependent pathway in human endothelial cells. J Cell Physiol 2005; 202: 434-441.
38. Chou, CT. Binding of rheumatoid and lupus synovial fluids and sera-derived human IgG rheumatoid factor to degalactosylated IgG. Arch Med Res 2002; 33: 541-544.
39. Taylor, DD, Bohler, HC, Gercel-Taylor, C. Pregnancy-linked suppression of TcR signaling pathways by a circulating factor absent in recurrent spontaneous pregnancy loss (RPL). Mol Immunol 2006; 43: 1872-1880.
40. Okamoto, T. NF-kappaB and rheumatic diseases. Endocr Metab Immune Disord Drug Targets 2006; 6: 359-372.
41. Goloubinoff, P, De Los Rios, P. The mechanism of Hsp70 chaperones: (entropic) pulling the models together. Trends Biochem Sci 2007; 32: 372-380.
42. Zampieri, S, Taccarino, L, Ghirardello, A, et al. Systemic lupus erythematosus, atherosclerosis, and autoantibodies. Ann N Y Acad Sci 2005; 1051: 351-361.
43. Conroy, SE, Tucker, L, Latchman, DS, Isenberg, DA. Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis. Clin Exp Rheumatol 1996; 4: 99-104.
44. Cederholm, A, Svenungsson, E, Stengel, D, et al. Platelet-activating factor-acetylhydrolase and other novel risk and protective factors for cardiovascular disease in systemic lupus erythematosus. Arthritis Rheum 2004; 50: 2869-2876.
45. Dieude, M, Seneca, JL, Raymond, Y. Induction of endothelial cell apoptosis by heat-shock protein 60-reactive antibodies from anti-endothelial cell autoantibody-positive systemic lupus erythematosus patients. Arthritis Rheum 2004; 50: 3221-3231.
46. Pratt, WB, Toft, DO, Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med 2003; 228: 111-133.
47. Latchman, DS, Isenberg, DA. The role of hsp90 in SLE. Autoimmunity 1994; 19: 211-218.
48. Dhillon, VB, McCallum, S, Latchman, DS, Isenberg, DA, Elevation of the 90 kD heat shock protein in specific subsets of systemic lupus erythematosus. Q J Med 1994; 87: 215-222.
49. Smith, MD, Dawson, SJ, Latchman, DS. The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Mol Cell Biol 1997; 17: 345-354.
50. Ripley, BJ, Rahman, MA, Isenberg, DA, Latchman, DS. Elevated ted expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90. Arthritis Rheum 2005; 52: 1171-1179.
51. Faulds, G, Conroy, S, Madaio, M, Isenberg, D, Latchman, D. Increased levels of antibodies to heat shock proteins with increasing age in Mrl/ Mp-lpr/lpr mice. Br J Rheumatol 1995; 34: 610-615.
52. Ripley, BJ, Isenberg, DA, Latchman, DS. Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90. J Autoimmun 2001; 17: 341-346.
53. Chiesa, C, Signore, F, Assumma, M, et al. Serial measurements of C-reactive protein and interleukin-6 in the immediate postnatal period: reference intervals and analysis of maternal and perinatal confounders. Clin Chem 2001; 47: 1016-1022.
54. Yoo, CG, Lee, S, Lee, CT, Kim, YW, Han, SK, Shim, YS. Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells. J Immunol 2000; 164: 5416-5423.
55. DeMeester, SL, Buchman, TG, Cobb, JP. The heat shock paradox: Does NF-kappaB determine cell fate. FASEB J 2001; 15: 270-274.
56. Endemann, M, Bergmeister, H, Bidmon, B, et al. Evidence for HSP-mediated cytoskeletal stabilization in mesothelial cells during acute experimental peritoneal dialysis. Am J Physiol Renal Physiol 2007; 292: F47-F56.
57. Noria, S, Xu, F, McCue, S, Jones, M, Gotlieb, AI, Langille, BL. Assembly and reorientation of stress fibers drives morphological changes to endothelial cells exposed to shear stress. Am J Pathol 2004; 164: 1211-1223.
58. Luo, SS, Sugimoto, K, Fujii, S, Takemasa, T, Fu, SB, Yamashita, K. Role of heat shock protein 70 in induction of stress fiebers formation in rat arterial endothelial cells in response to stretch stress. Acta Histochem Cytochem 2007; 40: 9-17.
59. Perng, MD, Muchowski, PJ, van Den, I, et al. The cardiomyopathy and lens cataract mutation in alpha B-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro. J Biol Chem 1999; 274: 33235-33243.
60. Garnier, C, Barbier, P, Gilli, R, Lopez, C, Peyrot, V, Briand, C. Heat-shock protein 90 (hsp90) binds in vitro to tubulin dimer and inhibits microtubule formation. Biochem Biophys Res Commun 1998; 250: 414-419.
61. Tsan, MF, Gao, B. Endogenous ligands of Toll-like receptors. J Leukoc Biol 2004; 76: 514-519.
62. Means, TK, Luster, AD. Toll-like receptor activation in the pathogenesis of systemic lupus eryhthematosus. Ann N Y Acad Sci 2005; 106: 242-251.
63. Krieg, AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002; 20: 709-760.
64. Merlo, A, Calcaterra, C, Menard, S, Balsari, A. Cross-talk between Toll-like receptors 5 and 9 on activation of human immune responses. J Leukoc Biol 2007; 82: 509-518.
65. Ghosh, TK, Mickelson, DJ, Solberg, JC, Lipson, KE, Inglefield, JR, Alkan, SS. TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha. Int Immunopharmacol 2007; 7: 1111-1121.
66. Morishima N. Control of cell fate by Hsp70: More than evanescent meeting. J Biochem 2005; 137: 449-453.
67. Paez, A, Mendez-Cruz, AR, Varela, E, et al. HUVEC from newborns with a strong family history of myocardial infarction overexpress adhesion molecules and react abnormally to stimulating agents. Clin Exp Immunol 2005; 141: 449-458.
68. Mendez-Cruz, AR, Paez, A, Jimenez-Flores, R, et al. Increased expression of inflammation-related co-stimulatory molecules by HUVEC from newborns with a strong family history of myocardial infarction stimulated with TNF-alpha and oxLDL. Immunol Lett 2007; 111: 116-123.