Is it possible to estimate the parameters of the sigmoid Emax model with truncated data typical of clinical studies?

Journal of Pharmaceutical Sciences

Volumn 85, Issue 2, 1996, Pages 232-239

  Dutta, Sandeep ^a   Matsumoto, Yoshiaki ^a,b   Ebling, William F ^a,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

ARTICLE; COMPUTER MODEL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT;

DOSE-RESPONSE RELATIONSHIP, DRUG; EVALUATION STUDIES; MODELS, THEORETICAL; STATISTICS;

EID: 0030021932     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950067y     Document Type: Article

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43. 0.
44. This assumes the drug can be characterized with direct acting pharmacodynamic models (absence of meaningful signal transduction delays) and that no tolerance develops or active metabolites are present.