A semiparametric method for describing noisy population pharmacokinetic data

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 25, Issue 5, 1997, Pages 615-642

  Park, Kyungsoo ^a,c   Verotta, Davide ^a   Blaschke, Terrence F ^b   Sheiner, Lewis B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Longitudinal spline; Mixed effects model; Nonparametric; Population pharmacokinetics; Random effects; Semiparametric

Indexed keywords

SAQUINAVIR;

ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; DATA ANALYSIS; DOSE TIME EFFECT RELATION; DRUG EFFICACY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; POPULATION RESEARCH; PRIORITY JOURNAL; STEADY STATE;

ANTI-HIV AGENTS; COMPUTER SIMULATION; HIV PROTEASE INHIBITORS; HUMANS; MODELS, THEORETICAL; PHARMACOKINETICS; PROSPECTIVE STUDIES; SAQUINAVIR; TECHNOLOGY, PHARMACEUTICAL;

EID: 0031403082     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025769431364     Document Type: Article

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