메뉴 건너뛰기




Volumn 5391 LNCS, Issue , 2009, Pages 246-259

Effects of HIV-1 proteins on the fas-mediated apoptotic signaling cascade: A computational study of latent CD4+ T cell activation

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; CELL DEATH; CELL SIGNALING; PROTEINS; REACTION RATES;

EID: 60349086412     PISSN: 03029743     EISSN: 16113349     Source Type: Book Series    
DOI: 10.1007/978-3-540-95885-7_18     Document Type: Conference Paper
Times cited : (2)

References (50)
  • 1
    • 0037178319 scopus 로고    scopus 로고
    • CCR5 Mediates Fas-and Caspase 8 Dependent Apoptosis of Both Uninfected and HIV Infected Primary Human CD4 T cells
    • Algeciras-Schimnich, A., et al.: CCR5 Mediates Fas-and Caspase 8 Dependent Apoptosis of Both Uninfected and HIV Infected Primary Human CD4 T cells. AIDS 16, 1467-1478 (2002)
    • (2002) AIDS , vol.16 , pp. 1467-1478
    • Algeciras-Schimnich, A.1
  • 2
    • 0037820578 scopus 로고    scopus 로고
    • Mechanisms of CD4 T Lymphocyte cell death in human immunodeficiency virus infection and AIDS
    • Alimonti, J., et al.: Mechanisms of CD4 T Lymphocyte cell death in human immunodeficiency virus infection and AIDS. J. Gen. Vir. 84, 1649-1661 (2003)
    • (2003) J. Gen. Vir , vol.84 , pp. 1649-1661
    • Alimonti, J.1
  • 3
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi, A., Dixit, V.: Death receptors: signaling and modulation. Science 281, 1305-1308 (1998)
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.2
  • 4
    • 0032978963 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/Caspase 8
    • Bartz, S., Emerman, M.: Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/Caspase 8. J. Vir. 73, 1956-1963 (1999)
    • (1999) J. Vir , vol.73 , pp. 1956-1963
    • Bartz, S.1    Emerman, M.2
  • 5
    • 0034654568 scopus 로고    scopus 로고
    • Biard-Piechaczyk, M., et al.: Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120). Vir. 268, 329-344 (2000)
    • Biard-Piechaczyk, M., et al.: Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120). Vir. 268, 329-344 (2000)
  • 6
    • 3042642144 scopus 로고    scopus 로고
    • The stoichiometry of Gag protein in HIV-1. Nature Struct
    • Mol, 11
    • Briggs, J., et al.: The stoichiometry of Gag protein in HIV-1. Nature Struct. Mol. Bio. 11, 672-675 (2004)
    • (2004) Bio , pp. 672-675
    • Briggs, J.1
  • 7
    • 0033681160 scopus 로고    scopus 로고
    • Biphasic decay of latently infected CD4+ T cells in acute HIV-1 infection
    • Blankson, J.N., et al.: Biphasic decay of latently infected CD4+ T cells in acute HIV-1 infection. J. Infect. Dis. 182, 1636-1642 (2000)
    • (2000) J. Infect. Dis , vol.182 , pp. 1636-1642
    • Blankson, J.N.1
  • 8
    • 0032577550 scopus 로고    scopus 로고
    • HIV entry and its inhibition
    • Chan, D., Kim, P.: HIV entry and its inhibition. Cell 93, 681-684 (1998)
    • (1998) Cell , vol.93 , pp. 681-684
    • Chan, D.1    Kim, P.2
  • 9
    • 0028792184 scopus 로고
    • In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
    • Chun, T.W., et al.: In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nature Med. 1, 1284-1290 (1995)
    • (1995) Nature Med , vol.1 , pp. 1284-1290
    • Chun, T.W.1
  • 10
    • 0030913366 scopus 로고    scopus 로고
    • Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
    • Chun, T.W., et al.: Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183-188 (1997)
    • (1997) Nature , vol.387 , pp. 183-188
    • Chun, T.W.1
  • 11
    • 0033973360 scopus 로고    scopus 로고
    • HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells
    • Cicala, C., et al.: HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells. Proc. Natl. Acad. Sci. U.S.A. 97, 1178-1183 (2000)
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 1178-1183
    • Cicala, C.1
  • 12
    • 0032472866 scopus 로고    scopus 로고
    • The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line possible implications for the pathogenesis of aids
    • Conti, L., et al.: The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line possible implications for the pathogenesis of aids. J. Exp. Med. 187, 403-413 (1998)
    • (1998) J. Exp. Med , vol.187 , pp. 403-413
    • Conti, L.1
  • 13
    • 0025968854 scopus 로고
    • Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex
    • Farnet, C., Haseltine, W.: Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex. J. Vir. 65, 1910-1915 (1991)
    • (1991) J. Vir , vol.65 , pp. 1910-1915
    • Farnet, C.1    Haseltine, W.2
  • 14
    • 0028912254 scopus 로고
    • Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
    • Finkel, T.: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Med. 1, 129-134 (1995)
    • (1995) Nature Med , vol.1 , pp. 129-134
    • Finkel, T.1
  • 15
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi, D., et al.: Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Med. 5, 512-517 (1999)
    • (1999) Nature Med , vol.5 , pp. 512-517
    • Finzi, D.1
  • 16
    • 0017030517 scopus 로고
    • A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
    • Gillespie, D.T.: A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. J. Comp. Phy. 22, 403-434 (1976)
    • (1976) J. Comp. Phy , vol.22 , pp. 403-434
    • Gillespie, D.T.1
  • 17
    • 33645429016 scopus 로고    scopus 로고
    • Gillespie, D.T.: Exact stochastic simulation of coupled chemical reactions. The J. Phy. Chem. 81, 2340-2361 (1997)
    • Gillespie, D.T.: Exact stochastic simulation of coupled chemical reactions. The J. Phy. Chem. 81, 2340-2361 (1997)
  • 18
    • 33846541321 scopus 로고    scopus 로고
    • Experimental approaches to the study of HIV-1 latency
    • Han, T., et al.: Experimental approaches to the study of HIV-1 latency. Microbio. 5, 95-106 (2007)
    • (2007) Microbio , vol.5 , pp. 95-106
    • Han, T.1
  • 19
    • 0030877601 scopus 로고    scopus 로고
    • Modulation of Bcl-2 Protein by CD4 Cross-Linking a possible mechanism for lympphocyte apoptosis in human immunodeficiency virus infection
    • Hashimoto, F., et al.: Modulation of Bcl-2 Protein by CD4 Cross-Linking a possible mechanism for lympphocyte apoptosis in human immunodeficiency virus infection. Blood 90, 745-753 (1997)
    • (1997) Blood , vol.90 , pp. 745-753
    • Hashimoto, F.1
  • 20
    • 27144553715 scopus 로고    scopus 로고
    • Effects of Bcl-2 levels on FAS signaling-induced caspase-3 activation: Molecular genetic tests of computational model predictions
    • Hua, F., et al.: Effects of Bcl-2 levels on FAS signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions. J. of Immun. 175, 6235-6237 (2005)
    • (2005) J. of Immun , vol.175 , pp. 6235-6237
    • Hua, F.1
  • 21
    • 0036547417 scopus 로고    scopus 로고
    • Igney, F., Krammer, P.: Death and anti-death: tumour resistance to apoptosis. Nature Rev. Can. 2, 277-288 (2002)
    • Igney, F., Krammer, P.: Death and anti-death: tumour resistance to apoptosis. Nature Rev. Can. 2, 277-288 (2002)
  • 22
    • 55849111218 scopus 로고    scopus 로고
    • Discrete nondeterministic modeling of the Fas pathway
    • accepted
    • Jack, J., et al.: Discrete nondeterministic modeling of the Fas pathway. Intern. J. Found. Computer Sci. (accepted, 2008)
    • (2008) Intern. J. Found. Computer Sci
    • Jack, J.1
  • 23
    • 0034598337 scopus 로고    scopus 로고
    • The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore
    • Jacotet, E., et al.: The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J. Exp. Med. 191, 33-45 (2000)
    • (2000) J. Exp. Med , vol.191 , pp. 33-45
    • Jacotet, E.1
  • 24
    • 0024347717 scopus 로고
    • Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: Evidence for differential gene expression
    • Kim, S., et al.: Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J. Vir. 63, 3708-3713 (1989)
    • (1989) J. Vir , vol.63 , pp. 3708-3713
    • Kim, S.1
  • 25
    • 0030939152 scopus 로고    scopus 로고
    • The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells
    • Kinoshita, S., et al.: The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Immun. 6, 235-244 (1997)
    • (1997) Immun , vol.6 , pp. 235-244
    • Kinoshita, S.1
  • 26
    • 33746631821 scopus 로고    scopus 로고
    • Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells
    • Lassen, K., et al.: Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells. PLoS Pathogens 2, 650-661 (2006)
    • (2006) PLoS Pathogens , vol.2 , pp. 650-661
    • Lassen, K.1
  • 27
    • 0030916417 scopus 로고    scopus 로고
    • DFF, a heterodimeric protein that functions downstream of Caspase-3 to trigger DNA fragmentation during apoptosis
    • Liu, X., et al.: DFF, a heterodimeric protein that functions downstream of Caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175-184 (1997)
    • (1997) Cell , vol.89 , pp. 175-184
    • Liu, X.1
  • 28
    • 0031568099 scopus 로고    scopus 로고
    • Dual role of HIV Tat in regulation of apoptosis in T cells
    • McCloskey, T., et al.: Dual role of HIV Tat in regulation of apoptosis in T cells. J. Immun. 158, 1014-1019 (1997)
    • (1997) J. Immun , vol.158 , pp. 1014-1019
    • McCloskey, T.1
  • 29
    • 0023176085 scopus 로고
    • An inducible transcription factor activates expression of human immunodeficiency virus in T cells
    • Nabel, G., Baltimore, D.: An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 344, 711-713 (1987)
    • (1987) Nature , vol.344 , pp. 711-713
    • Nabel, G.1    Baltimore, D.2
  • 30
    • 0036301125 scopus 로고    scopus 로고
    • CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of CyclinT1 promotes its nuclear localization
    • Napolitano, G., et al.: CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of CyclinT1 promotes its nuclear localization. J. Cell. Phys. 192, 209-215 (2002)
    • (2002) J. Cell. Phys , vol.192 , pp. 209-215
    • Napolitano, G.1
  • 31
    • 0036848194 scopus 로고    scopus 로고
    • HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation
    • Nie, Z., et al.: HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation. Cell Death Diff. 9, 1172-1184 (2002)
    • (2002) Cell Death Diff , vol.9 , pp. 1172-1184
    • Nie, Z.1
  • 32
    • 0027960659 scopus 로고
    • Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion
    • Oyaizu, N., et al.: Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion. Blood 84, 2622-2631 (1994)
    • (1994) Blood , vol.84 , pp. 2622-2631
    • Oyaizu, N.1
  • 33
    • 12444250746 scopus 로고    scopus 로고
    • Membrane Computing
    • Springer, Heidelberg
    • Pǎun, G.: Membrane Computing. An Introduction. Springer, Heidelberg (2002)
    • (2002) An Introduction
    • Pǎun, G.1
  • 34
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson, A.S., et al.: Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387, 188-191 (1997)
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1
  • 35
    • 0036340605 scopus 로고    scopus 로고
    • Molecular characterization of preintegration latency in HIV-1 infection
    • Pierson, T.C., et al.: Molecular characterization of preintegration latency in HIV-1 infection. J. Virol. 76, 8518-8531 (2002)
    • (2002) J. Virol , vol.76 , pp. 8518-8531
    • Pierson, T.C.1
  • 36
    • 0037279111 scopus 로고    scopus 로고
    • Autoimmune lymphoproliferative syndromes: Genetic defects of apoptosis pathways
    • Rieux-Laucat, F., et al.: Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways. Cell Death Diff. 10, 124-133 (2003)
    • (2003) Cell Death Diff , vol.10 , pp. 124-133
    • Rieux-Laucat, F.1
  • 37
    • 34248579519 scopus 로고    scopus 로고
    • Out of Africa: What can we learn from HIV-2 about protective immunity to HIV-1
    • Roland-Jones, S.L., Whittle, H.C.: Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1. Nature Imm. 9, 329-331 (2007)
    • (2007) Nature Imm , vol.9 , pp. 329-331
    • Roland-Jones, S.L.1    Whittle, H.C.2
  • 38
    • 0035085350 scopus 로고    scopus 로고
    • Using death to one's advantage: HIV modulation and apoptosis
    • Ross, T.: Using death to one's advantage: HIV modulation and apoptosis. Leuk. 15, 332-341 (2001)
    • (2001) Leuk , vol.15 , pp. 332-341
    • Ross, T.1
  • 39
    • 0032536771 scopus 로고    scopus 로고
    • Two CD95 (APO-1/Fas) signaling pathways
    • Scaffidi, C., et al.: Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675-1687 (1998)
    • (1998) EMBO J , vol.17 , pp. 1675-1687
    • Scaffidi, C.1
  • 40
    • 0035093156 scopus 로고    scopus 로고
    • Biochemical mechanisms of HIV induced T cell apoptosis
    • Selliah, N., Finkel, T.: Biochemical mechanisms of HIV induced T cell apoptosis. Cell Death Diff. 8, 127-136 (2001)
    • (2001) Cell Death Diff , vol.8 , pp. 127-136
    • Selliah, N.1    Finkel, T.2
  • 41
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
    • Siliciano, J.D., et al.: Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nature Med. 9, 727-728 (2003)
    • (2003) Nature Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1
  • 42
    • 9544225179 scopus 로고    scopus 로고
    • Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2
    • Strack, L., et al.: Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2. Proc. Natl. Acad. Sci. U.S.A. 93, 9571-9576 (1996)
    • (1996) Proc. Natl. Acad. Sci. U.S.A , vol.93 , pp. 9571-9576
    • Strack, L.1
  • 43
    • 0242584383 scopus 로고    scopus 로고
    • Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence
    • Strain, M.C., et al.: Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence. Proc. Natl. Acad. Sci. U.S.A. 100, 4819-4824 (2003)
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 4819-4824
    • Strain, M.C.1
  • 44
    • 36549011407 scopus 로고    scopus 로고
    • World Health Organization 2007 AIDS Epidemic Update, http://www.who.int/ hiv/en/
    • (2007) AIDS Epidemic Update
  • 45
    • 0032546844 scopus 로고    scopus 로고
    • The HIV-1 envelope glycoproteins: Fusogens, antigens, and immunogens
    • Wyatt, R., Sodroski, J.: The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens. Science 280, 1884-1888 (1998)
    • (1998) Science , vol.280 , pp. 1884-1888
    • Wyatt, R.1    Sodroski, J.2
  • 46
    • 0037205474 scopus 로고    scopus 로고
    • HIV Tat binds Egr proteins and enhances Egr-dependent trans-activation of the Fas ligand promoter
    • Yang, Y., et al.: HIV Tat binds Egr proteins and enhances Egr-dependent trans-activation of the Fas ligand promoter. J. Bio. Chem. 277, 19482-19487 (2002)
    • (2002) J. Bio. Chem , vol.277 , pp. 19482-19487
    • Yang, Y.1
  • 47
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • Zack, J.A., et al.: HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61, 213-222 (1990)
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1
  • 48
    • 0026526144 scopus 로고
    • Incompletely reverse-transcribed human immunodeficiency virus type I genomes function as intermediates in the retroviral life cycle
    • Zack, J.A., et al.: Incompletely reverse-transcribed human immunodeficiency virus type I genomes function as intermediates in the retroviral life cycle. J. Vir. 66, 1717-1725 (1992)
    • (1992) J. Vir , vol.66 , pp. 1717-1725
    • Zack, J.A.1
  • 49
    • 0032959989 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef protein sensitizes CD4+ T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway
    • Zauli, G., et al.: Human immunodeficiency virus type 1 Nef protein sensitizes CD4+ T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. Blood 93, 1000-1010 (1999)
    • (1999) Blood , vol.93 , pp. 1000-1010
    • Zauli, G.1
  • 50
    • 13444309162 scopus 로고    scopus 로고
    • Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells
    • Zhou, Y., et al.: Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells. J. Vir. 79, 2199-2210 (2005)
    • (2005) J. Vir , vol.79 , pp. 2199-2210
    • Zhou, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.