Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4

Molecular and Cellular Endocrinology

Volumn 301, Issue 1-2, 2009, Pages 199-204

  Lee, Wen Hwa ^a   Lukacik, Petra ^a   Guo, Kunde ^a   Ugochukwu, Emilie ^a   Kavanagh, Kathryn L ^a   Marsden, Brian ^a,c   Oppermann, Udo ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Aldo keto reductase; Bile acid metabolism; Docking; Homology modelling; X ray crystallography

Indexed keywords

OXIDOREDUCTASE;

ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; CATALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

BILE ACIDS AND SALTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, MOLECULAR; OXIDOREDUCTASES; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 60249092438     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.09.042     Document Type: Article

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