Methoxychlor-induced alteration in the levels of HSP70 and clusterin is accompanied with oxidative stress in adult rat testis

Journal of Biochemical and Molecular Toxicology

Volumn 23, Issue 1, 2009, Pages 29-35

  Vaithinathan, S ^a   Saradha, B ^a   Mathur, P P ^a  

^a PONDICHERRY UNIVERSITY   (India)

Author keywords

Clusterin; Heat shock protein; Methoxychlor; Oxidative stress

Indexed keywords

CATALASE; CLUSTERIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72; METHOXYCHLOR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DAMAGE; CELL PROTECTION; ENZYME ACTIVITY; HOMOGENATE; IMMUNOBLOTTING; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; TESTIS; TISSUE LEVEL;

ANIMALS; CATALASE; CLUSTERIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HSC70 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; LIPID PEROXIDATION; MALE; METHOXYCHLOR; OXIDATIVE STRESS; RATS; RATS, WISTAR; SOLUBILITY; SUPEROXIDE DISMUTASE; TESTIS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 59949087982     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20262     Document Type: Article

References (41)

1. Pflieger-Bruss S, Schuppe HC, Schill WB. The male reproductive system and its susceptibility to endocrine disrupting chemicals. Andrologia 2004;36:337-345.
2. Saradha B, Vaithinathan S, Sarkar O, Mathur PP. Reproductive toxicants: Perspectives and research prospects. Embryo Talk 2006;1:62-67.
3. Pant N, Mathur N, Banerjee AK, Srivastava SP, Saxena DK. Correlation of chlorinated pesticides concentration in semen with seminal vesicle and prostatic markers. Reprod Toxicol 2004;19:209-214.
4. Staub C, Hardy VB, Chapin RE, Harris MW, Johnson L. The hidden effect of estrogenic/antiandrogenic methoxychlor on spermatogenesis. Toxicol Appl Pharmacol 2002;180:129-135.
5. Okazaki K, Okazaki S, Nishimura S, Nakamura H, Kitamura Y, Hatayama K, Nakamura A, Tsuda T, Katsumata T, Nishikawa A, Hirose M. A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the "enhanced OECD test guideline 407" for screening endocrine-disrupting chemicals. Arch Toxicol 2001;75:513-521.
6. Latchoumycandane C, Mathur PP. Induction of oxidative stress in the rat testis after short-term exposure to the organochlorine pesticide methoxychlor. Arch Toxicol 2002;76:692-698.
7. Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A. Pesticides and oxidative stress: A review. Med Sci Monit 2004;10:RA141-RA147.
8. Latchoumycandane C, Mathur PP. Effect of methoxychlor on the antioxidant system in mitochondrial and microsome-rich fractions of rat testis. Toxicology 2002;176:67-75.
9. Latchoumycandane C, Chitra KC, Mathur PP. The effect of methoxychlor on the epididymal antioxidant system of adult rats. Reprod Toxicol 2002;16:161-172.
10. Vaithinathan S, Saradha B, Mathur PP. Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: An in vivo study. Arch Toxicol 2008. DOI 10.1007/s00204-008-0301-2.
11. Waters KM, Safe S, Gaido KW. Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. Toxicol Sci 2001;63:47-56.
12. Hartl FU. Molecular chaperones in cellular protein folding. Nature 1996;381:571-579.
13. Neuer A, Spandorfer SD, Giraldo P, Dieterle S, Rosenwaks Z, Witkin SS. The role of heat shock proteins in reproduction. Hum Reprod Update 2000;6:149-159.
14. De Maio A. Heat shock proteins: Facts, thoughts, and dreams. Shock 1999;11:1-12.
15. Fritz IB, Burdzy K, Setchell B, Blaschuk O. Ram rete testis fluid contains a protein (clusterin) which influences cell-cell interactions in vitro. Biol Reprod 1983;28:1173-1188.
16. Bailey RW, Aronow B, Harmony JA, Griswold MD. Heat shock-initiated apoptosis is accelerated and removal of damaged cells is delayed in the testis of clusterin/ApoJ knock-out mice. Biol Reprod 2002;66:1042-1053.
17. Samali A, Orrenius S. Heat shock proteins: Regulators of stress response and apoptosis. Cell Stress Chaperones 1998;3:228-236.
18. Shannan B, Seifert M, Leskov K, Willis J, Boothman D, Tilgen W, Reichrath J. Challenge and promise: Roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death Differ. 2006;13:12-19.
19. Trougakos IP, Gonos ES. Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res 2006;40:1324-1334.
20. Fukushima T, Yamamoto T, Kikkawa R, Hamada Y, Komiyama M, Mori C, Horii I. Effects of male reproductive toxicants on gene expression in rat testes. J. Toxicol Sci 2005;30:195-206.
21. Migliarini B, Campisi AM, Maradonna F, Truzzi C, Annibaldi A, Scarponi G, Carnevali O. Effects of cadmium exposure on testis apoptosis in the marine teleost Gobius niger. Gen Comp Endocrinol 2005;142:241-247.
22. Saradha B, Vaithinathan S, Mathur PP. Lindane alters the levels of HSP70 and clusterin in adult rat testis. Toxicology 2008;243:116-123.
23. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
24. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-474.
25. Beauchamp C, Fridovich I. Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels. Anal Biochem. 1971;44:276-287.
26. Claiborne A. Catalase activity. In: Greenwald RA, editor. Handbook of methods for oxygen free radical research. Boca Raton, FL: CRC Press; 1985. pp 283-284.
27. Sun Y, Elwell JH, Oberley LW. A simultaneous visualization of the antioxidant enzymes glutathione peroxidase and catalase on polyacrylamide gels. Free Radic Res Commun 1988;5:67-75.
28. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358.
29. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
30. Kapoor IP, Metcalf RL, Nystrom RF, Sangha GK. Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem. J Agric Food Chem 1970;18:1145-1152.
31. WHO. Guidelines for Drinking Water-Quality. Health Criteria and other supporting information. Geneva: World Hsealth Organization; 1996.
32. Saradha B, Mathur PP. Effect of environmental contaminants on male reproduction. Environ Toxicol Pharmacol 2006;21:34-41.
33. Peltola V, Huhtaniemi I, Ahotupa M. Antioxidant enzyme activity in the maturing rat testis. J Androl 1992;13:450-455.
34. Tiemann U, Pohland R, Kuchenmeister U, Viergutz T. Influence of organochlorine pesticides on transmembrane potential, oxidative activity, and ATP-induced calcium release in cultured bovine oviductal cells. Reprod Toxicol 1998;12:551-557.
35. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology. Pharmacol Ther 1998;80:183-201.
36. Gonzalez B, Manso R. Induction, modification and accumulation of HSP70s in the rat liver after acute exercise: Early and late responses. J Physiol 2004;556:369-385.
37. Trudell JR, Lin WQ, Chrystof DA, Kirshenbaum G, Ardies CM. Induction of HSP72 in rat liver by chronic ethanol consumption combined with exercise: Association with the prevention of ethanol-induced fatty liver by exercise. Alcohol Clin Exp Res 1995;19:753-758.
38. Viard I, Wehrli P, Jornot L, Bullani R, Vechietti JL, Schifferli JA, Tschopp J, French LE. Clusterin gene expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress. J Invest Dermatol 1999;112:290-296.
39. Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza RP, Fryer JD, Kierson M, Cirrito J, Quick K, Harmony JA, Aronow BJ, Holtzman DM. Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nat Med 2001;7:338-343.
40. Trougakos IP, Lourda M, Agiostratidou G, Kletsas D, Gonos ES. Differential effects of clusterin/apolipoprotein J on cellular growth and survival. Free Radic Biol Med 2005;38:436-449.
41. Liossis SN, Ding XZ, Kiang JG, Tsokos GC. Overexpression of the heat shock protein 70 enhances the TCR/CD3-and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells. J Immunol 1997;158:5668-5675.