Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: An in vivo study

Archives of Toxicology

Volumn 82, Issue 11, 2008, Pages 833-839

  Vaithinathan, S ^a   Saradha, B ^a   Mathur, P P ^a  

^a PONDICHERRY UNIVERSITY   (India)

Author keywords

17 hydroxysteroid dehydrogenase; 3 hydroxysteroid dehydrogenase; Androgen binding protein; Methoxychlor; Steroidogenic acute regulatory protein; Testis

Indexed keywords

3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ANDROGEN BINDING PROTEIN; HYDROGEN PEROXIDE; METHOXYCHLOR; ORGANOCHLORINE PESTICIDE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE 17BETA DEHYDROGENASE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; STEROIDOGENESIS; TESTIS;

17-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; ADMINISTRATION, ORAL; ANDROGEN-BINDING PROTEIN; ANIMALS; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; INSECTICIDES; MALE; METHOXYCHLOR; PHOSPHOPROTEINS; RATS; RATS, WISTAR; TESTIS; TIME FACTORS;

RATTUS;

EID: 57249089398     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0301-2     Document Type: Article

References (37)

1. Agency for Toxic Substance, Disease Registry (2002) Toxicological profile for methoxychlor. US Department of Health and Human Services, Atlanta
2. BT Akingbemi RS Ge GR Klinefelter GL Gunsalus MP Hardy 2000 A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, reduces testosterone biosynthesis in rat Leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme Biol Reprod 62 571 578
3. Bergmeyer HU (1974) β-Hydroxysteroid dehydrogenase. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vol. 1. Academic Press, New York, pp 447-489
4. RE Chapin MW Harris BJ Davis SM Ward RE Wilson MA Mauney AC Lockhart RJ Smialowicz VC Moser LT Burka BJ Collins 1997 The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function Fundam Appl Toxicol 40 138 157
5. CPCSEA 2003 CPCSEA guidelines for laboratory animal facility Indian J Pharmacol 35 257 274
6. AM Cummings 1997 Methoxychlor as a model for environmental estrogens Crit Rev Toxicol 27 367 379
7. T Diemer JA Allen KH Hales DB Hales 2003 Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis Endocrinology 144 2882 2891
8. T Endo RF Aten L Leykin HR Behrman 1993 Hydrogen peroxide evokes antisteroidogenic and antigonadotropic actions in human granulosa luteal cells J Clin Endocrinol Metab 76 337 342
9. KW Gaido SC Maness DP McDonnell SS Dehal D Kupfer S Safe 2000 Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies Mol Pharmacol 58 852 858
10. LE Gray Jr J Ostby J Ferrell G Rehnberg R Linder R Cooper J Goldman V Slott J Laskey 1989 A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat Fundam Appl Toxicol 12 92 108
11. GL Gunsalus F Larrea NA Musto RR Becker JP Mather CW Bardin 1981 Androgen binding protein as a marker for Sertoli cell function J Steroid Biochem 15 99 106
12. I Hanukoglu R Rapoport L Weiner D Sklan 1993 Electron leakage from the mitochondrial NADPH-adrenodoxin reductase-adrenodoxin-P450scc (cholesterol side chain cleavage) system Arch Biochem Biophys 305 489 498
13. PJ Hornsby 1980 Regulation of cytochrome P-450-supported 11 beta-hydroxylation of deoxycortisol by steroids, oxygen, and antioxidants in adrenocortical cell cultures J Biol Chem 255 4020 4027
14. Johnson L, Chapin RE, Harris MW, Silge RL, Guidry AC, Lee WR (2000) Perinatal/juvenile exposure to methoxychlor reduces Sertoli cell numbers in adult rats. Soc Toxicol 364
15. N Jorgensen AG Andersen F Eustache DS Irvine J Suominen JH Petersen AN Andersen J Auger EH Cawood A Horte TK Jensen P Jouannet N Keiding M Vierula J Toppari NE Skakkebaek 2001 Regional differences in semen quality in Europe Hum Reprod 16 1012 1019
16. UK Laemmli 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 680 685
17. C Latchoumycandane PP Mathur 2002 Induction of oxidative stress in the rat testis after short-term exposure to the organochlorine pesticide methoxychlor Arch Toxicol 76 692 698
18. C Latchoumycandane KC Chitra PP Mathur 2002 The effect of methoxychlor on the epididymal antioxidant system of adult rats Reprod Toxicol 16 161 172
19. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275
20. EP Murono RC Derk 2004 The effects of the reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, on testosterone formation by cultured Leydig cells from young adult rats Reprod Toxicol 19 135 146
21. EP Murono RC Derk Y Akgul 2006 In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity Reprod Toxicol 21 148 153
22. P Murugesan T Muthusamy K Balasubramanian J Arunakaran 2007 Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells Toxicology 232 170 182
23. S Pflieger-Bruss HC Schuppe WB Schill 2004 The male reproductive system and its susceptibility to endocrine disrupting chemicals Andrologia 36 337 345
24. E Pick Y Keisari 1981 Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages-induction by multiple nonphagocytic stimuli Cell Immunol 59 301 318
25. PG Quinn AH Payne 1985 Steroid product-induced, oxygen-mediated damage of microsomal cytochrome P-450 enzymes in Leydig cell cultures. Relationship to desensitization J Biol Chem 260 2092 2099
26. SS Raychoudhury AF Flowers CF Millette MF Finlay 2000 Toxic effects of polychlorinated biphenyls on cultured rat Sertoli cells J Androl 21 964 973
27. MM Reddy SV Mahipal J Subhashini MC Reddy KR Roy GV Reddy PR Reddy P Reddanna 2006 Bacterial lipopolysaccharide-induced oxidative stress in the impairment of steroidogenesis and spermatogenesis in rats Reprod Toxicol 22 493 500
28. B Saradha PP Mathur 2006 Effect of environmental contaminants on male reproduction Environ Toxicol Pharmacol 21 34 41
29. B Saradha S Vaithinathan PP Mathur 2008 Lindane alters the levels of HSP70 and clusterin in adult rat testis Toxicology 243 116 123
30. B Saradha S Vaithinathan PP Mathur 2008 Single exposure to low dose of lindane causes transient decrease in testicular steroidogenesis in adult male Wistar rats Toxicology 244 190 197
31. A Steinberger G Klinefelter 1993 Sensitivity of Sertoli and Leydig cells to xenobiotics in in vitro models Reprod Toxicol 7 Suppl 1 S23 S37
32. DM Stocco BJ Clark 1996 Regulation of the acute production of steroids in steroidogenic cells Endocr Rev 17 221 244
33. DM Stocco J Wells BJ Clark 1993 The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells Endocrinology 133 2827 2832
34. DJ Tindall JS Tash AR Means 1981 Factor affecting Sertoli cell function in the testis Environ Health Perspect 38 5 10
35. LP Walsh DM Stocco 2000 Effects of lindane on steroidogenesis and steroidogenic acute regulatory protein expression Biol Reprod 63 1024 1033
36. WHO (1996) Guidelines for drinking water quality, 2nd ed, vol 2. Health criteria and other supporting information. World Health Organization, Geneva
37. R Zachow M Uzumcu 2006 The methoxychlor metabolite, 2,2-bis-(p- hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro Reprod Toxicol 22 659 665