-
1
-
-
0034727066
-
Multiple sclerosis
-
Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med 2000;343(13): 938-52.
-
(2000)
N Engl J Med
, vol.343
, Issue.13
, pp. 938-952
-
-
Noseworthy, J.H.1
Lucchinetti, C.2
Rodriguez, M.3
Weinshenker, B.G.4
-
2
-
-
0037029424
-
Multiple sclerosis
-
Compston A, Coles A. Multiple sclerosis. Lancet 2002; 359: 1221-31.
-
(2002)
Lancet
, vol.359
, pp. 1221-1231
-
-
Compston, A.1
Coles, A.2
-
3
-
-
39449090773
-
Genetics and natural history of multiple sclerosis
-
Kantarci OH. Genetics and natural history of multiple sclerosis. Semin Neurol 2008: 28(1): 7-16.
-
(2008)
Semin Neurol
, vol.28
, Issue.1
, pp. 7-16
-
-
Kantarci, O.H.1
-
4
-
-
76449088213
-
-
Available from, Accessed January 15, 2008
-
National Multiple Sclerosis Society. Who gets MS? Available from www.nationalmssociety.org/about-multiple-sclerosis/ who- gets-ms/index.aspx. Accessed January 15, 2008.
-
Who gets MS
-
-
-
5
-
-
33846995128
-
Current trends in multiple sclerosis research: An update on pathogenic concepts
-
Vanderlocht J, Hellings N, Hendriks JJ, Stinissen P. Current trends in multiple sclerosis research: an update on pathogenic concepts. Acta Neurol Belg 2006;106(4): 180-90.
-
(2006)
Acta Neurol Belg
, vol.106
, Issue.4
, pp. 180-190
-
-
Vanderlocht, J.1
Hellings, N.2
Hendriks, J.J.3
Stinissen, P.4
-
6
-
-
33847635657
-
Neurodegeneration in autoimmune demyelination: Recent mechanistic insights reveal novel therapeutic targets
-
Aktas O, Waiczies S, Zipp F. Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets. J Neuroimmunol 2007;184: 17-26.
-
(2007)
J Neuroimmunol
, vol.184
, pp. 17-26
-
-
Aktas, O.1
Waiczies, S.2
Zipp, F.3
-
7
-
-
33746778816
-
Drug insight: Using monoclonal antibodies to treat multiple sclerosis
-
Hohlfeld R, Wekerle H. Drug insight: using monoclonal antibodies to treat multiple sclerosis. Nat Clin Pract Neurol 2005;1(1): 34-44.
-
(2005)
Nat Clin Pract Neurol
, vol.1
, Issue.1
, pp. 34-44
-
-
Hohlfeld, R.1
Wekerle, H.2
-
9
-
-
59949093443
-
-
Hoffmann-La Roche Inc. Zenapax (daclizumab) package insert. Nutley, NJ; 2005
-
Hoffmann-La Roche Inc. Zenapax (daclizumab) package insert. Nutley, NJ; 2005.
-
-
-
-
10
-
-
17744397506
-
Use of daclizumab as initial immunosuppression in liver transplant recipients with impaired renal function
-
Emre S, Gondolesi G, Polat K, et al. Use of daclizumab as initial immunosuppression in liver transplant recipients with impaired renal function. Liver Transpl 2001;7(3): 220-5.
-
(2001)
Liver Transpl
, vol.7
, Issue.3
, pp. 220-225
-
-
Emre, S.1
Gondolesi, G.2
Polat, K.3
-
11
-
-
0027956688
-
Treatment of acute a graft-versus-host disease with humanized anti-tac: An antibody that binds to the interleukin-2 receptor
-
Anasetti C, Hansen JA, Waldmann TA, et al. Treatment of acute a graft-versus-host disease with humanized anti-tac: an antibody that binds to the interleukin-2 receptor. Blood 1994;84(4): 1320-7.
-
(1994)
Blood
, vol.84
, Issue.4
, pp. 1320-1327
-
-
Anasetti, C.1
Hansen, J.A.2
Waldmann, T.A.3
-
12
-
-
0028310517
-
Anti-IL-2 receptor monoclonal antibody (anti- Tac) treatment of T cell lymphoma
-
Waldmann TA. Anti-IL-2 receptor monoclonal antibody (anti- Tac) treatment of T cell lymphoma. Important Adv Oncol 1994;8: 131-41.
-
(1994)
Important Adv Oncol
, vol.8
, pp. 131-141
-
-
Waldmann, T.A.1
-
13
-
-
13044311376
-
Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: A phase I/II clinical trial
-
Nussenblatt RB, Fortin E, Schiffman R, et al. Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. Proc Natl Acad Sci U SA1999;96: 7462-6.
-
(1999)
Proc Natl Acad Sci U SA
, vol.96
, pp. 7462-7466
-
-
Nussenblatt, R.B.1
Fortin, E.2
Schiffman, R.3
-
14
-
-
10744222484
-
-
Nussenblatt RB, Thompson DJ, Li Z, et al. Humanized anti- interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration. J Autoimmun 2003;21(3): 283-93. (Erratum in J Autoimmun 2004;23(1): 93.)
-
Nussenblatt RB, Thompson DJ, Li Z, et al. Humanized anti- interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration. J Autoimmun 2003;21(3): 283-93. (Erratum in J Autoimmun 2004;23(1): 93.)
-
-
-
-
15
-
-
2942537826
-
-
Bielekova B, Richert N, Howard T, et al. Humanized anti- CD25 ( daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β. Proc Natl Acad Sci U S A 2004;101(23): 8705-8. (Erratum in Proc Natl Acad Sci U S A 2004;101(50): 17565.)
-
Bielekova B, Richert N, Howard T, et al. Humanized anti- CD25 ( daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β. Proc Natl Acad Sci U S A 2004;101(23): 8705-8. (Erratum in Proc Natl Acad Sci U S A 2004;101(50): 17565.)
-
-
-
-
16
-
-
33645812129
-
-
bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci U S A 2006;103(15): 5941-6.
-
bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci U S A 2006;103(15): 5941-6.
-
-
-
-
17
-
-
9644265478
-
Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody
-
Rose JW, Watt HE, White AT, Carlson NG. Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody. Ann Neurol 2004;56: 864-7.
-
(2004)
Ann Neurol
, vol.56
, pp. 864-867
-
-
Rose, J.W.1
Watt, H.E.2
White, A.T.3
Carlson, N.G.4
-
18
-
-
34548142973
-
Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results
-
Rose JW, Burns JB, Bjorklund J, Klein J, Watt HE, Carlson NG. Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results. Neurology 2007;69(8): 785-9.
-
(2007)
Neurology
, vol.69
, Issue.8
, pp. 785-789
-
-
Rose, J.W.1
Burns, J.B.2
Bjorklund, J.3
Klein, J.4
Watt, H.E.5
Carlson, N.G.6
-
19
-
-
0029913882
-
Defining the clinical course of multiple sclerosis: Results of an international survey. National multiple sclerosis (USA) advisory committee on clinical trials of new agents in multiple sclerosis
-
Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National multiple sclerosis (USA) advisory committee on clinical trials of new agents in multiple sclerosis. Neurology 1996;46(4): 907-11.
-
(1996)
Neurology
, vol.46
, Issue.4
, pp. 907-911
-
-
Lublin, F.D.1
Reingold, S.C.2
-
20
-
-
0013317152
-
Current disease-modifying therapies in multiple sclerosis
-
Kieseier BC, Hartung H. Current disease-modifying therapies in multiple sclerosis. Semin Neurol 2003;23: 133-45.
-
(2003)
Semin Neurol
, vol.23
, pp. 133-145
-
-
Kieseier, B.C.1
Hartung, H.2
-
21
-
-
34047189953
-
New therapeutic approaches for multiple sclerosis
-
De Jager PL, Hafler DA. New therapeutic approaches for multiple sclerosis. Annu Rev Med 2007;58: 417-32.
-
(2007)
Annu Rev Med
, vol.58
, pp. 417-432
-
-
De Jager, P.L.1
Hafler, D.A.2
-
22
-
-
39449138202
-
Current evidence and therapeutic strategies for multiple sclerosis
-
Wingerchuk DM. Current evidence and therapeutic strategies for multiple sclerosis. Semin Neurol 2008;28: 56-68.
-
(2008)
Semin Neurol
, vol.28
, pp. 56-68
-
-
Wingerchuk, D.M.1
-
23
-
-
0043022062
-
New and emerging treatment options for multiple sclerosis
-
Polman CH, Uitdehaag BM. New and emerging treatment options for multiple sclerosis. Lancet Neurol 2003;2(9): 563-6.
-
(2003)
Lancet Neurol
, vol.2
, Issue.9
, pp. 563-566
-
-
Polman, C.H.1
Uitdehaag, B.M.2
-
24
-
-
34447104396
-
Relatio nship o f immunologic abnormalities and disease stage in multiple sclerosis: Implications for therapy
-
Vaknin-Dembinsky A, Weiner HL. Relatio nship o f immunologic abnormalities and disease stage in multiple sclerosis: implications for therapy. J Neurol Sci 2007;259: 90-4.
-
(2007)
J Neurol Sci
, vol.259
, pp. 90-94
-
-
Vaknin-Dembinsky, A.1
Weiner, H.L.2
-
25
-
-
34249734136
-
New concepts on progressive multiple sclerosis
-
Lassmann H. New concepts on progressive multiple sclerosis. Curr Neurol Neurosci Rep 2007;7: 239-44.
-
(2007)
Curr Neurol Neurosci Rep
, vol.7
, pp. 239-244
-
-
Lassmann, H.1
-
26
-
-
10344220493
-
The use of magnetic resonance imaging in the diagnosis and long-term management of multiple sclerosis
-
Bakshi R, Hutton GJ, Miller JR, Radue EW. The use of magnetic resonance imaging in the diagnosis and long-term management of multiple sclerosis. Neurology 2004;63(suppl5): S3-11.
-
(2004)
Neurology
, vol.63
, Issue.SUPPL.5
-
-
Bakshi, R.1
Hutton, G.J.2
Miller, J.R.3
Radue, E.W.4
-
27
-
-
2542418047
-
Role of MRI in multiple sclerosis I: Inflammation and lesions
-
Zivadinov R, Bakshi R. Role of MRI in multiple sclerosis I: inflammation and lesions. Front Biosci 2004;9: 665-83.
-
(2004)
Front Biosci
, vol.9
, pp. 665-683
-
-
Zivadinov, R.1
Bakshi, R.2
-
28
-
-
2542435940
-
Role of MRI in multiple sclerosis II: Brain and spinal cord atrophy
-
Zivadinov R, Bakshi R. Role of MRI in multiple sclerosis II: brain and spinal cord atrophy. Front Biosci 2004;9: 647-64.
-
(2004)
Front Biosci
, vol.9
, pp. 647-664
-
-
Zivadinov, R.1
Bakshi, R.2
-
29
-
-
0030780349
-
Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology
-
Bruck W, Bitsch A, Kolenda H, Bruck Y, Strefel H, Lassmann H. Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997;42: 783-93.
-
(1997)
Ann Neurol
, vol.42
, pp. 783-793
-
-
Bruck, W.1
Bitsch, A.2
Kolenda, H.3
Bruck, Y.4
Strefel, H.5
Lassmann, H.6
-
30
-
-
28544436950
-
Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald criteria" Ann
-
Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald criteria" Ann Neurol 2005;58: 840-6.
-
(2005)
Neurol
, vol.58
, pp. 840-846
-
-
Polman, C.H.1
Reingold, S.C.2
Edan, G.3
-
31
-
-
39449133109
-
Recent advances in neuroimaging of multiple sclerosis
-
Rashid W, Miller D. Recent advances in neuroimaging of multiple sclerosis. Semin Neurol 2008;28: 46-55.
-
(2008)
Semin Neurol
, vol.28
, pp. 46-55
-
-
Rashid, W.1
Miller, D.2
-
32
-
-
0034716486
-
Therapeutic monoclonal antibodies
-
Breedveld FC. Therapeutic monoclonal antibodies. Lancet 2000;355: 735-40.
-
(2000)
Lancet
, vol.355
, pp. 735-740
-
-
Breedveld, F.C.1
-
33
-
-
33747616656
-
Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
-
Presta LG. Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv Drug Deliv Rev 2006;58: 640-56.
-
(2006)
Adv Drug Deliv Rev
, vol.58
, pp. 640-656
-
-
Presta, L.G.1
-
34
-
-
14844285410
-
The therapeutic antibodies market to 2008
-
Pavlou AK, Belsey MJ. The therapeutic antibodies market to 2008. Eur J Pharm Biopharm 2005;59: 389-96.
-
(2005)
Eur J Pharm Biopharm
, vol.59
, pp. 389-396
-
-
Pavlou, A.K.1
Belsey, M.J.2
-
35
-
-
59949099721
-
-
4th ed. Bethesda, MD: American Society of Health-System Pharmacists
-
Smith BT. Concepts in immunology and immunotherapeutics, 4th ed. Bethesda, MD: American Society of Health-System Pharmacists, 2008;25-48.
-
(2008)
Concepts in immunology and immunotherapeutics
, pp. 25-48
-
-
Smith, B.T.1
-
36
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256: 495-7.
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
37
-
-
34848920472
-
Emerging therapies for multiple sclerosis
-
Muraro PA, Bielekova B. Emerging therapies for multiple sclerosis. Neurotherapeutics 2007;4: 676-92.
-
(2007)
Neurotherapeutics
, vol.4
, pp. 676-692
-
-
Muraro, P.A.1
Bielekova, B.2
-
38
-
-
36749041328
-
Interleukin 2: From immuno- stimulation to immunoregulation and back again
-
Bachmann MF, Oxenius A. Interleukin 2: from immuno- stimulation to immunoregulation and back again. EMBO Rep 2007;8(12): 1142-8.
-
(2007)
EMBO Rep
, vol.8
, Issue.12
, pp. 1142-1148
-
-
Bachmann, M.F.1
Oxenius, A.2
-
39
-
-
33745837261
-
Differential regulation of T-cell growth by IL-1 and IL-15
-
Cornish GH, Sinclair LV, Cantrell DA. Differential regulation of T-cell growth by IL-1 and IL-15. Blood 2006;108: 600-8.
-
(2006)
Blood
, vol.108
, pp. 600-608
-
-
Cornish, G.H.1
Sinclair, L.V.2
Cantrell, D.A.3
-
40
-
-
41949097030
-
The biology of interleukin-2
-
Malek TR. The biology of interleukin-2. Annu Rev Immunol 2008;26: 453-79.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
41
-
-
0036200407
-
The IL-2/IL-15 receptor systems: Targets for immunotherapy
-
Waldmann TA. The IL-2/IL-15 receptor systems: targets for immunotherapy. J Clin Immunol 2002;22(2): 51-6.
-
(2002)
J Clin Immunol
, vol.22
, Issue.2
, pp. 51-56
-
-
Waldmann, T.A.1
-
42
-
-
17844364666
-
-
bright regulatory NK cells in patient with active uveitis. J Immunol 2005;174(9): 5187-91. (Erratum in J Immunol 2005;175(5): 3447.)
-
bright regulatory NK cells in patient with active uveitis. J Immunol 2005;174(9): 5187-91. (Erratum in J Immunol 2005;175(5): 3447.)
-
-
-
-
43
-
-
37849032623
-
Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: Relevance of natural killer cells
-
Airas L, Saraste M, Rinta S, et al. Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells. Clin Exp Immunol 2007; 151: 235-43.
-
(2007)
Clin Exp Immunol
, vol.151
, pp. 235-243
-
-
Airas, L.1
Saraste, M.2
Rinta, S.3
-
44
-
-
34447290007
-
bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta
-
bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta. Neurol Sci 2007;28(3): 121-6.
-
(2007)
Neurol Sci
, vol.28
, Issue.3
, pp. 121-126
-
-
Saraste, M.1
Irjala, H.2
Airas, L.3
-
45
-
-
34250024900
-
Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on c ell divisio n and Th1 /Th2 cytokine production
-
Snyder JT, Shen J, Azmi H, Hou J, Fowler DH, Ragheb JA. Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on c ell divisio n and Th1 /Th2 cytokine production. Blood 2007;109(12): 5399-406.
-
(2007)
Blood
, vol.109
, Issue.12
, pp. 5399-5406
-
-
Snyder, J.T.1
Shen, J.2
Azmi, H.3
Hou, J.4
Fowler, D.H.5
Ragheb, J.A.6
-
46
-
-
84868870303
-
-
Available from, Accessed December 2, 2007
-
Montalban X, Wynn D, Kaufman M, on behalf of CHOICE Investigators. Daclizumab in patients with active, relapsing multiple sclerosis on concurrent interferon-beta therapy: week 24 data-phase II (CHOICE) study [slide presentation]. 2007. Available from www.pdl.com/documents/ectrims-2007-pdf. pdf. Accessed December 2, 2007.
-
(2007)
on behalf of CHOICE Investigators. Daclizumab in patients with active, relapsing multiple sclerosis on concurrent interferon-beta therapy: Week 24 data-phase II (CHOICE) study [slide presentation]
-
-
Montalban, X.1
Wynn, D.2
Kaufman, M.3
-
48
-
-
37149023520
-
Humanized anti-CD25 antibody treatment with dac lizumab in multiple sclero sis
-
Martin R. Humanized anti-CD25 antibody treatment with dac lizumab in multiple sclero sis. Neuro de ge ner Dis 2008;5: 23-6.
-
(2008)
Neuro de ge ner Dis
, vol.5
, pp. 23-26
-
-
Martin, R.1
-
49
-
-
34250687536
-
Compared benefit of approved and experimental immuno suppressive therapeutic appro aches in multiple sclerosis
-
Gonsette RE. Compared benefit of approved and experimental immuno suppressive therapeutic appro aches in multiple sclerosis. Expert Opin Pharmacother 2007;8(8): 1103-16.
-
(2007)
Expert Opin Pharmacother
, vol.8
, Issue.8
, pp. 1103-1116
-
-
Gonsette, R.E.1
-
50
-
-
59949088276
-
-
EMD Serono, Inc. Rebif (interferon beta-1a) package insert. Rockland, MA; 2008
-
EMD Serono, Inc. Rebif (interferon beta-1a) package insert. Rockland, MA; 2008.
-
-
-
-
51
-
-
59949092269
-
-
Biogen Idec Inc. Avonex (interferon beta-1a) package insert. Cambridge, MA; 2006
-
Biogen Idec Inc. Avonex (interferon beta-1a) package insert. Cambridge, MA; 2006.
-
-
-
-
52
-
-
59949095380
-
-
Bayer Healthcare Pharmaceuticals Inc. Betaseron (interferon beta-1b) package insert. Wayne, NJ; 2007
-
Bayer Healthcare Pharmaceuticals Inc. Betaseron (interferon beta-1b) package insert. Wayne, NJ; 2007.
-
-
-
-
53
-
-
59949087342
-
-
Teva Neuroscience, Inc. Co paxone, glatiramer acetate package insert. Kansas City, MO; 2007
-
Teva Neuroscience, Inc. Co paxone ( glatiramer acetate) package insert. Kansas City, MO; 2007.
-
-
-
-
54
-
-
59949104343
-
-
EMD Serono, Inc. Novantrone (mitoxantrone) package insert. Rockland, MA; 2006
-
EMD Serono, Inc. Novantrone (mitoxantrone) package insert. Rockland, MA; 2006.
-
-
-
-
55
-
-
59949086973
-
-
Biogen Idec Inc. Tysabri, natalizumab package insert. Cambridge, MA; 2008
-
Biogen Idec Inc. Tysabri ( natalizumab) package insert. Cambridge, MA; 2008.
-
-
-
-
56
-
-
0042011476
-
Rational therapy for relapsing multiple sclerosis
-
Wolinsky JS. Rational therapy for relapsing multiple sclerosis. Lancet Neurol 2003;2: 271-2.
-
(2003)
Lancet Neurol
, vol.2
, pp. 271-272
-
-
Wolinsky, J.S.1
-
57
-
-
34447102777
-
The gap between effect of drugs and effectiveness of treatments
-
Sorensen S. The gap between effect of drugs and effectiveness of treatments. J Neurol Sci 2007;259: 128-32.
-
(2007)
J Neurol Sci
, vol.259
, pp. 128-132
-
-
Sorensen, S.1
-
58
-
-
34447299372
-
Glatiramer acetate in multiple sclerosis: A review
-
Ruggieri M, Avolio C, Livrea P, Trojano M. Glatiramer acetate in multiple sclerosis: a review. CNS Drug Rev 2007;13(2): 178-91.
-
(2007)
CNS Drug Rev
, vol.13
, Issue.2
, pp. 178-191
-
-
Ruggieri, M.1
Avolio, C.2
Livrea, P.3
Trojano, M.4
-
59
-
-
0345601517
-
-
PRISMS (Prevention of Relapses and Disability by Interferon Beta-la Subcutaneously in Multiple Sclerosis) Study Group. Randomized double-blind place bo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 1998;352(9139): 1498-504. (Erratum in Lancet 1999;353(9153): 678.)
-
PRISMS (Prevention of Relapses and Disability by Interferon Beta-la Subcutaneously in Multiple Sclerosis) Study Group. Randomized double-blind place bo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 1998;352(9139): 1498-504. (Erratum in Lancet 1999;353(9153): 678.)
-
-
-
-
60
-
-
0008678962
-
Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis: The multiple sclerosis collaborative research group (MSCRG)
-
Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis: the multiple sclerosis collaborative research group (MSCRG). Ann Neurol 1996;39: 285-94.
-
(1996)
Ann Neurol
, vol.39
, pp. 285-294
-
-
Jacobs, L.D.1
Cookfair, D.L.2
Rudick, R.A.3
-
61
-
-
0035091667
-
European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging-measured disease activity and burden in patients with relapsing multiple sclerosis
-
for the European/Canadian Glatiramer Acetate Study Group
-
Comi G, Filippi M, Wolinsky JS, et al, for the European/Canadian Glatiramer Acetate Study Group. European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging-measured disease activity and burden in patients with relapsing multiple sclerosis. Ann Neurol 2001;49: 290-7.
-
(2001)
Ann Neurol
, vol.49
, pp. 290-297
-
-
Comi, G.1
Filippi, M.2
Wolinsky, J.S.3
-
62
-
-
0035849496
-
Randomized controlled trial of interferon beta-1a in secondary progressive MS
-
SPECTRIMS (Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-Beta-1a in MS) Study Group
-
SPECTRIMS (Secondary Progressive Efficacy Clinical Trial of Recombinant Interferon-Beta-1a in MS) Study Group. Randomized controlled trial of interferon beta-1a in secondary progressive MS. Neurology 2001;56: 1496-504.
-
(2001)
Neurology
, vol.56
, pp. 1496-1504
-
-
-
63
-
-
8844222623
-
Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study. The North American study group on interferon beta-1b in secondary progressive MS
-
Panitch H, Miller A, Paty D, et al. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. The North American study group on interferon beta-1b in secondary progressive MS. Neurology 2004;63: 1788-95.
-
(2004)
Neurology
, vol.63
, pp. 1788-1795
-
-
Panitch, H.1
Miller, A.2
Paty, D.3
-
64
-
-
0032494792
-
Placebo-controlled multicentre randomized trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis
-
European Study Group on Interferon Beta-1b in Secondary Progressive MS
-
European Study Group on Interferon Beta-1b in Secondary Progressive MS. Placebo-controlled multicentre randomized trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet 1998;352: 1491-7.
-
(1998)
Lancet
, vol.352
, pp. 1491-1497
-
-
-
65
-
-
33846833929
-
Glatiramer acetate in primary progressive multiple sclerosis: Results of a multinational, multicenter, double-blind, placebo-controlled trial: the promise trial study group
-
Wolinsky JS, Narayana PA, O'Connor P, et al. Glatiramer acetate in primary progressive multiple sclerosis: results of a multinational, multicenter, double-blind, placebo-controlled trial: the promise trial study group. Ann Neurol 2007;61: 14-24.
-
(2007)
Ann Neurol
, vol.61
, pp. 14-24
-
-
Wolinsky, J.S.1
Narayana, P.A.2
O'Connor, P.3
-
66
-
-
84868890238
-
-
Bayer HealthCare AG. Therapy of multiple sclerosis BEYOND study: results do not support regulatory filing for Betaferon® 500 mcg [press release]. October 29, 2007. Available from www.betaseron.com/patients/pdfs/ BEYOND%20Study%20News %20Release.pdf. AccessedJuly 2, 2008.
-
Bayer HealthCare AG. Therapy of multiple sclerosis BEYOND study: results do not support regulatory filing for Betaferon® 500 mcg [press release]. October 29, 2007. Available from www.betaseron.com/patients/pdfs/ BEYOND%20Study%20News %20Release.pdf. AccessedJuly 2, 2008.
-
-
-
-
67
-
-
10944231932
-
Mechanism of action of mitoxantrone
-
Fox EJ. Mechanism of action of mitoxantrone. Neurology 2004;63(suppl 6): S15-18.
-
(2004)
Neurology
, vol.63
, Issue.SUPPL. 6
-
-
Fox, E.J.1
-
68
-
-
0022450390
-
Selective immuno- modulation by the antineoplastic agent mitoxantrone, I: Suppression of B lymphocyte function
-
Fidler JM, DeJoy SQ, Gibbons JJ Jr. Selective immuno- modulation by the antineoplastic agent mitoxantrone, I: suppression of B lymphocyte function. J Immunol 1986;137: 727-32.
-
(1986)
J Immunol
, vol.137
, pp. 727-732
-
-
Fidler, J.M.1
DeJoy, S.Q.2
Gibbons Jr, J.J.3
-
69
-
-
0022635318
-
-
Fidler JM, DeJoy SQ, Smith FR III, Gibbons JJ Jr. Selective immunomodulation by the antineoplastic agent mitoxantrone, II: no nspec ific adherent suppressor cells de rived from mitoxantrone-treated mice. J Immunol 1986;136: 2747-54.
-
Fidler JM, DeJoy SQ, Smith FR III, Gibbons JJ Jr. Selective immunomodulation by the antineoplastic agent mitoxantrone, II: no nspec ific adherent suppressor cells de rived from mitoxantrone-treated mice. J Immunol 1986;136: 2747-54.
-
-
-
-
70
-
-
34250613901
-
Mitoxantrone treatment leads to a persistent selective decrease of the B cell count in patients with multiple sclerosis [abstract]
-
abstract P06.160
-
Putzki N, Kumar M, Vago S, Kreutzfelder E, Limmroth V. Mitoxantrone treatment leads to a persistent selective decrease of the B cell count in patients with multiple sclerosis [abstract]. Neurology 2006;66(suppl 2): A370, abstract P06.160.
-
(2006)
Neurology
, vol.66
, Issue.SUPPL. 2
-
-
Putzki, N.1
Kumar, M.2
Vago, S.3
Kreutzfelder, E.4
Limmroth, V.5
-
71
-
-
0026010353
-
Suppre ssion o f de myelination by mitoxantrone
-
Watson CM, Davison AN, Baker D, O'Neil JK, Turk JL. Suppre ssion o f de myelination by mitoxantrone. Int J Immunopharmacol 1991;13(7): 923-30.
-
(1991)
Int J Immunopharmacol
, vol.13
, Issue.7
, pp. 923-930
-
-
Watson, C.M.1
Davison, A.N.2
Baker, D.3
O'Neil, J.K.4
Turk, J.L.5
-
72
-
-
0037153729
-
-
Hartung H, G onsette R, Konig N, et al. Mitoxantrone in progressive multiple sclerosis: a placebo controlled, double- blind, randomized, multicentre trial. Lancet 2002;360: 2018-25.
-
Hartung H, G onsette R, Konig N, et al. Mitoxantrone in progressive multiple sclerosis: a placebo controlled, double- blind, randomized, multicentre trial. Lancet 2002;360: 2018-25.
-
-
-
-
73
-
-
10944258663
-
Review of mitoxantrone in the treatment of multiple sclerosis
-
Jeffery DR, Herndon R. Review of mitoxantrone in the treatment of multiple sclerosis. Neurology 2004; 63(suppl 6): S19-24.
-
(2004)
Neurology
, vol.63
, Issue.SUPPL. 6
-
-
Jeffery, D.R.1
Herndon, R.2
-
74
-
-
34247854822
-
Studie;ve O, Bennett JL. Pharmacological properties, toxicology and scientific rationale for the use of natalizumab (Tysabri) in inflammatory diseases
-
Studie;ve O, Bennett JL. Pharmacological properties, toxicology and scientific rationale for the use of natalizumab (Tysabri) in inflammatory diseases. CNS Drug Rev 2007;13(1): 79-94.
-
(2007)
CNS Drug Rev
, vol.13
, Issue.1
, pp. 79-94
-
-
-
75
-
-
33646347610
-
Immune surveillance in multiple sclerosis patients treated with natalizumab
-
Stüve O, Marta CM, Jerome KR, et al. Immune surveillance in multiple sclerosis patients treated with natalizumab. Ann Neurol 2006;59: 743-7.
-
(2006)
Ann Neurol
, vol.59
, pp. 743-747
-
-
Stüve, O.1
Marta, C.M.2
Jerome, K.R.3
-
76
-
-
33644584352
-
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
-
for the AFFIRM Investigators
-
Polman CH, O'Connor PW, Havrdova E, et al, for the AFFIRM Investigators. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006;354: 899-910.
-
(2006)
N Engl J Med
, vol.354
, pp. 899-910
-
-
Polman, C.H.1
O'Connor, P.W.2
Havrdova, E.3
-
77
-
-
33644608613
-
Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
-
for the SENTINEL Investigators
-
Rudick RA, Stuart WH, Calabresi PA, et al, for the SENTINEL Investigators. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med 2006;354: 911-23.
-
(2006)
N Engl J Med
, vol.354
, pp. 911-923
-
-
Rudick, R.A.1
Stuart, W.H.2
Calabresi, P.A.3
-
78
-
-
22844439662
-
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
-
Kleinschmidt-DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 2005;353: 369-74.
-
(2005)
N Engl J Med
, vol.353
, pp. 369-374
-
-
Kleinschmidt-DeMasters, B.K.1
Tyler, K.L.2
-
79
-
-
22844445230
-
Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
-
Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005;353: 375-81.
-
(2005)
N Engl J Med
, vol.353
, pp. 375-381
-
-
Langer-Gould, A.1
Atlas, S.W.2
Green, A.J.3
Bollen, A.W.4
Pelletier, D.5
-
80
-
-
22844445587
-
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
-
Van Assche G, Van Ranst M, Sciot R, et al. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 2005;353: 362-8.
-
(2005)
N Engl J Med
, vol.353
, pp. 362-368
-
-
Van Assche, G.1
Van Ranst, M.2
Sciot, R.3
-
82
-
-
33644605483
-
Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
-
Yousry TA, Major EO, Ryschkewitsch C, et al. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N EnglJ Med 2006;354: 924-33.
-
(2006)
N EnglJ Med
, vol.354
, pp. 924-933
-
-
Yousry, T.A.1
Major, E.O.2
Ryschkewitsch, C.3
-
83
-
-
36148969823
-
Postwithdrawal rebound increase in T2 lesional activity in natalizumab treated MS patient
-
Vellinga MM, Castelijns JA, Barkhof F, Uitdehaag BMJ, Polman CH. Postwithdrawal rebound increase in T2 lesional activity in natalizumab treated MS patient. Neurology 2007;69: 1-2.
-
(2007)
Neurology
, vol.69
, pp. 1-2
-
-
Vellinga, M.M.1
Castelijns, J.A.2
Barkhof, F.3
Uitdehaag, B.M.J.4
Polman, C.H.5
-
84
-
-
34248365318
-
Combination therapies for multiple sclerosis: Scientific rationale, clinical trials, and clinical practice
-
Costello F, Sẗve O, Weber MS, Zamvil SS, Frohman E. Combination therapies for multiple sclerosis: scientific rationale, clinical trials, and clinical practice. Curr Opin Neurol 2007;20(3): 281-5.
-
(2007)
Curr Opin Neurol
, vol.20
, Issue.3
, pp. 281-285
-
-
Costello, F.1
Sẗve, O.2
Weber, M.S.3
Zamvil, S.S.4
Frohman, E.5
-
85
-
-
46849091551
-
Glatiramer acetate after induction therapy with mitoxantrone in relapsing multiple sclerosis
-
Vollmer T, Panitch H, Bar-Or A, et al. Glatiramer acetate after induction therapy with mitoxantrone in relapsing multiple sclerosis. Mult Scler 2008;14(5): 663-70.
-
(2008)
Mult Scler
, vol.14
, Issue.5
, pp. 663-670
-
-
Vollmer, T.1
Panitch, H.2
Bar-Or, A.3
-
86
-
-
39049136067
-
Combination therapy with interferon beta-1a and doxycycline in multiple sclerosis: An open-label trial
-
Minagar A, Alexander JS, Schwendimann RN, et al. Combination therapy with interferon beta-1a and doxycycline in multiple sclerosis: an open-label trial. Arch Neuro l 2008;656(2): 199-204.
-
(2008)
Arch Neuro l
, vol.656
, Issue.2
, pp. 199-204
-
-
Minagar, A.1
Alexander, J.S.2
Schwendimann, R.N.3
-
87
-
-
10944271463
-
Use of combination therapy with immuno-modulators and immunosuppressants in treating multiple sclerosis
-
Jeffery DR. Use of combination therapy with immuno-modulators and immunosuppressants in treating multiple sclerosis. Neurology 2004;63: S41-6.
-
(2004)
Neurology
, vol.63
-
-
Jeffery, D.R.1
-
88
-
-
10344229910
-
Concomitant therapy for multiple sclerosis
-
Stuart WH, Vermersch P. Concomitant therapy for multiple sclerosis. Neurology 2004;63(suppl 5): S28-34.
-
(2004)
Neurology
, vol.63
, Issue.SUPPL. 5
-
-
Stuart, W.H.1
Vermersch, P.2
-
90
-
-
33749137775
-
Combination therapy
-
Martinelli V. Combination therapy. Neurol Sci 2006; 27: S350-4.
-
(2006)
Neurol Sci
, vol.27
-
-
Martinelli, V.1
-
91
-
-
54149093179
-
-
planned, in progress, recently completed. Available from, Accessed June 22, 2008
-
National Multiple Sclerosis Society. Clinical trials in multiple sclerosis 2008: planned, in progress, recently completed. Available from www.nationalmssociety.org/research/clinical-trials/download.aspx?id=224. Accessed June 22, 2008.
-
(2008)
Clinical trials in multiple sclerosis
-
-
|