The role of non-invasive dynamic tests in the diagnosis of Cushing's syndrome

Journal of Endocrinological Investigation

Volumn 31, Issue 11, 2008, Pages 1008-1013

  Vilar, L ^a,b,d   Freitas, M C ^b   Naves, L A ^c   Canadas, V ^a   Albuquerque, J L ^a   Botelho, C A ^a   Egito, C S ^a   Arruda, M J ^a   Silva, L M ^a   Arahata, C M ^a   Agra, R ^a   Lima, L H C ^b   Azevedo, M ^c   Casulari, L A ^c  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b Center for Diabetes and Endocrinology of Pernambuco   (Brazil)

^c HOSPITAL UNIVERSITÁRIO DE BRASÍLIA   (Brazil)

^d NONE   (Brazil)

Author keywords

Cushing's syndrome; Diagnosis

Indexed keywords

CORTICOTROPIN; DESMOPRESSIN; DEXAMETHASONE; HYDROCORTISONE;

ADRENAL TUMOR; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CUSHING SYNDROME; DEXAMETHASONE SUPPRESSION TEST; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DRUG MEGADOSE; ECTOPIC CORTICOTROPIN PRODUCTION; HORMONE INHIBITION; HUMAN; HYDROCORTISONE BLOOD LEVEL; IMMUNOREACTIVITY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; NON INVASIVE PROCEDURE; NUCLEAR MAGNETIC RESONANCE IMAGING; SALIVA LEVEL; SENSITIVITY ANALYSIS;

EID: 59849111735     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345640     Document Type: Article

References (34)

1. Vilar L, Coelho CE. Diagnosis and differential diagnosis of Cushing's syndrome. In: Vilar L, Kater CE, Naves LA eds. Clinical Endocrinology. 3rd ed. Rio de Janeiro: Guanabara Koogan. 2006, 397-417.
2. Newell-Price J, Trainer P, Besser GM, Grossman A. The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocr Rev 1998, 19: 647-72.
3. Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing's syndrome. Lancet 2006, 367: 1605-17.
4. Vilar L, Freitas MC, Faria M, et al. Pitfalls in the diagnosis of Cushing's syndrome. Arq Bras Endocrinol Metab 2007, 51: 1207-16.
5. Findling JW, Raff H. Screening and diagnosis of Cushing's syndrome. Endocrinol Metab Clin North Am 2005, 34: 385-402.
6. Lindsay JR, Nieman LK. Differential diagnosis and imaging in Cushing's syndrome. Endocrinol Metab Clin North Am 2005, 34: 403-22.
7. Wood PJ, Barth JH, Freedman DB, Perry L, Sheridan B. Evidence for the low dose dexamethasone suppression test to screen for Cushing's syndrome-recommendations for a protocol for biochemistry laboratories. Ann Clin Biochem 1997, 34: 222-9.
8. Newell-Price J, Trainer P, Perry L, Wass J, Grossman A, Besser M. A single sleeping midnight Cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf) 1995, 43: 545-50.
9. Bruno OD, Rossi MA, Contreras LN, et al. Nocturnal high-dose dexamethasone suppression test in the aetiological diagnosis of Cushing's syndrome. Acta Endocrinol (Copenh) 1985, 109: 158-62.
10. Tyrrell JB, Findling JW, Aran DC, Fitzgerald PA, Forsham PH. An overnight high-dose dexamethasone suppression test for rapid differential diagnosis of Cushing's syndrome. Ann Intern Med 1986, 104: 180-6.
11. Terzolo M, Reimondo G, Ali A, et al. The limited value of the desmopressin test in the diagnostic approach to Cushing's syndrome. Clin Endocrinol (Oxf) 2001, 54: 609-16.
12. Nieman LK, Oldfield EH, Wesley R, Chrousos GP, Loriaux DL, Cutler GB Jr. A simplified morning ovine corticotropin-releasing hormone stimulation test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 1993, 77: 1308-12.
13. Oldfield EH, Chrousos GP, Schulte HM, et al. Preoperative lateralization of ACTH-secreting pituitary microadenomas by bilateral and simultaneous inferior petrosal venous sinus sampling. N Engl J Med 1985, 312: 100-3.
14. Castinetti F, Morange I, Dufour H, et al. Desmopressin test during petrosal sinus sampling: a valuable tool to discriminate pituitary or ectopic ACTH-dependent Cushing's syndrome. Eur J Endocrinol 2007, 157:271-7.
15. Findling JW, Kehoe ME, Shaker JL, Raff H. Routine inferior petrosal sinus sampling in the differential diagnosis of adrenocorticotropin (ACTH)-dependent Cushing's syndrome: early recognition of the occult ectopic ACTH syndrome. J Clin Endocrinol Metab 1991, 73: 408-13.
16. Vilar L, Freitas MC, Canadas V, et al. Performance of low-dose dexamethasone suppression tests in obesity and in Cushing's syndrome. Arq Bras Endocrinol Metab 2002, 46 (Suppl. 1): S493-4.
17. Findling JW, Raff H. Screening and diagnosis of Cushing's syndrome. Endocrinol Metab Clin North Am 2005, 34: 385-402.
18. Kaye TB, Crapo L. The Cushing syndrome: an update on diagnostic tests. Ann Intern Med 1990, 112: 434-44.
19. Meier CA, Biller BMK. Clinical and biochemical evaluation of Cushing's syndrome. Endocrinol Metab Clin N Am 1997, 26: 741-62.
20. Mengden T, Hubmann P, Muller J, Greminger P, Vetter W. Urinary free Cortisol vs 17-hydroxycorticosteroids: a comparative study of their diagnostic value in Cushing's syndrome. Clin Invest 1992, 70: 545-8.
21. Nieman LK, Cutler GB Jr. The sensitivity of the urine free Cortisol measurement as a screening test for Cushing's syndrome. Program of the 72nd Annual Meeting of the Endocrine Society, Atlanta, GA, 1990, p. 822 (abstract)
22. Isidori AM, Kaltsas GA, Pozza C, et al. The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up. J Clin Endocrinol Metab 2006, 91: 371-7.
23. Ilias I, Torpy DJ, Pacak K, Mullen N, Wesley RA, Nieman LK. Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health. J Clin Endocrinol Metab 2005, 90: 4955-62.
24. Salgado LR, Fragoso MCBV, Knoepfelmacher M, et al. Ectopic ACTH syndrome: our experience with 25 cases. Eur J Endocrinol 2006, 155: 725-33.
25. Dichek HL, Nieman LK, Oldfield EH, Pass HI, Malley JD, Cutler GB Jr. A comparison of the standard high dose dexamethasone suppression test and the overnight 8-mg dexamethasone suppression test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 1994, 78: 418-22.
26. Findling JW, Raff H. Cushing's syndrome: Important issues in diagnosis and management. J Clin Endocrinol Metab 2006, 91: 3746-53.
27. Invitti C, Pecori Giraldi F, de Martin M, Cavagnini F. Diagnosis and management of Cushing's syndrome: results of an Italian multicentre study. Study group of the Italian Society of Endocrinology on the Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis. J Clin Endocrinol Metab 1999, 84: 440-8.
28. Loli P, Vignati F, Grossrubatscher E, et al. Management of occult adrenocorticotropin-secreting bronchial carcinoids: limits of endocrine testing and imaging techniques. J Clin Endocrinol Metab 2003, 88: 1029-35.
29. Reimondo G, Paccotti P, Minetto M, et al. The corticotrophin-releasing hormone test is the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushing's syndrome. Clin Endocrinol (Oxf) 2003, 58: 718-24.
30. Malerbi DA, Mendonça BB, Liberman B, et al. The desmopressin stimulation test in the differential diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf) 1993, 38: 463-72.
31. Colombo P, Passini E, Re T, Faglia G, Ambrosi B. Effect of desmopressin on ACTH and Cortisol secretion in states of ACTH excess. Clin Endocrinol (Oxf) 1997, 46: 661-8.
32. Tsagarakis S, Tsigos C, Vasiliou V, et al. The desmopressin and combined CRH-desmopressin tests in the differential diagnosis of ACTH-dependent Cushing's syndrome: constraints imposed by the expression of V2 vasopressin receptors in tumors with ectopic ACTH secretion. J Clin Endocrinol Metab 2002, 87: 1646-53.
33. de Keyzer Y, Lenne F, Auzan C, et al. The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. J Clin Invest 1996, 97: 1311-8.
34. Testa RM, Albiger N, Occhi G, et al. The usefulness of combined biochemical tests in the diagnosis of Cushing's disease with negative pituitary magnetic resonance imaging. Eur J Endocrinol 2007, 156: 241-8.