Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport

Journal of Lipid Research

Volumn 49, Issue 10, 2008, Pages 2212-2217

  Zhao, Bin ^a   Song, Jingmei ^a   Ghosh, Shobha ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bile acid excretion; HDL cholesteryl esters; Lipoprotein cholesterol removal; Liver; Selective uptake

Indexed keywords

BILE ACID; CHOLESTEROL; CHOLESTEROL ESTERASE; SCAVENGER RECEPTOR BI;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BILE LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FECES LEVEL; GENE OVEREXPRESSION; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADENOVIRIDAE; ANIMALS; BILE; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL LINE; CHOLESTEROL; CHOLESTEROL, HDL; FECES; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPOPROTEINS; LIVER; MACROPHAGES; MICE; STEROL ESTERASE;

EID: 59849095754     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800277-JLR200     Document Type: Article

References (30)

1. Dietschy, J. M., S. D. Turley, and D. K. Spady. 1993. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34: 1637-1659.
2. Kendrick, J. S., J. Wilkinson, I. J. Cartwright, S. Lawrence, and J. A. Higgins. 1998. Regulation of the assembly and secretion of very low density lipoproteins by the liver. Biol. Chem. 379: 1033-1040.
3. Rhainds, D., and L. Brissette. 1999. Low density lipoprotein uptake: holoparticle and cholesteryl ester selective uptake. Int. J. Biochem. Cell Biol. 31: 915-931.
4. Shashkin, P., B. Dragulev, and K. Ley. 2005. Macrophage differentiation to foam cells. Curr. Pharm. Des. 11: 3061-3072.
5. Johnson, W. J., F. H. Mahlberg, G. H. Rothblat, and M. C. Phillips. 1991. Cholesterol transport between cells and high-density lipoproteins. Biochim. Biophys. Acta. 1085: 273-298.
6. Rothblat, G. H., M. de la Llera-Moya, E. Favari, P. G. Yancey, and G. Kellner-Weibel. 2002. Cellular cholesterol flux studies: methodological considerations. Atherosclerosis. 163: 1-8.
7. Trigatti, B., A. Rigotti, and M. Krieger. 2000. The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism. Curr. Opin. Lipidol. 11: 123-131.
8. Kozarsky, K. F., M. H. Donahee, A. Rigotti, S. N. Iqbal, E. R. Edelman, and M. Krieger. 1997. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature. 387: 414-417.
9. Goodman, Z. D., and V. S. Lequire. 1975. Transfer of esterified cholesterol from serum lipoproteins to the liver. Biochim. Biophys. Acta. 398: 325-336.
10. Shimada, A., T. Tamai, K. Oida, S. Takahashi, J. Suzuki, T. Nakai, and S. Miyabo. 1994. Increase in neutral cholesteryl ester hydrolase activity produced by extralysosomal hydrolysis of high-density lipoprotein cholesteryl esters in rat hepatoma cells (H-35). Biochim. Biophys. Acta. 1215: 126-132.
11. Ghosh, S. 2000. Cholesteryl ester hydrolase in human monocyte/ macrophage: cloning, sequencing, and expression of full-length cDNA. Physiol. Genomics. 2: 1-8.
12. Zhao, B., R. Natarajan, and S. Ghosh. 2005. Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role in cellular cholesterol homeostasis. Physiol. Genomics. 23: 304-310.
13. Ghosh, S., R. W. St Clair, and L. L. Rudel. 2003. Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase. J. Lipid Res. 44: 1833-1840.
14. Zhao, B., J. Song, W. N. Chow, R. W. St Clair, L. L. Rudel, and S. Ghosh. 2007. Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice. J. Clin. Invest. 117: 2983-2992.
15. Robins, S. J., J. M. Fasulo, D. Lessard, and G. M. Patton. 1993. Hepatic cholesterol synthesis and the secretion of newly synthesized cholesterol in bile. Biochem. J. 289: 41-44.
16. Empen, K., K. Lange, and E. F. Stange. 1997. Newly synthesized cholesterol in human bile and plasma: quantification by mass isotopomer distribution analysis. Am. J. Physiol. Gastrointest. Liver Physiol. 272: G367-G373.
17. Schwartz, C. C., M. Berman, Z. R. Vlahcevic, L. G. Halloran, D. H. Gregory, and L. Swell. 1978. Multicompartmental analysis of cholesterol metabolism in man. Characterization of the hepatic bile acid and biliary cholesterol precursor sites. J. Clin. Invest. 61: 408-423.
18. Schwartz, C. C., L. G. Halloran, Z. R. Vlahcevic, D. H. Gregory, and L. Swell. 1978. Preferential utilization of free cholesterol from high-density lipoproteins for biliary cholesterol secretion in man. Science. 200: 62-64.
19. Ghosh, S., and W. M. Grogan. 1989. Activation of rat liver cholesterol ester hydrolase by cAMP-dependent protein kinase and protein kinase C. Lipids. 24: 733-736.
20. Ren, S., P. B. Hylemon, D. Marques, E. Gurley, P. Bodhan, E. Hall, K. Redford, G. Gil, and W. M. Pandak. 2004. Overexpression of cholesterol transporter StAR increases in vivo rates of bile acid synthesis in the rat and mouse. Hepatology. 40: 910-917.
21. Zhao, B., J. Song, R. W. St Clair, and S. Ghosh. 2007. Stable over-expression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages. Am. J. Physiol. Cell Physiol. 292: C405-C412.
22. Zhang, Y., I. Zanotti, M. P. Reilly, J. M. Glick, G. H. Rothblat, and D. J. Rader. 2003. Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation. 108: 661-663.
23. Batta, A. K., G. Salen, K. R. Rapole, M. Batta, P. Batta, D. Alberts, and D. Earnest. 1999. Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. J. Lipid Res. 40: 1148-1154.
24. Zhang, Y., J. R. Da Silva, M. Reilly, J. T. Billheimer, G. H. Rothblat, and D. J. Rader. 2005. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J. Clin. Invest. 115: 2870-2874.
25. Pieters, M. N., S. Esbach, D. Schouten, A. Brouwer, D. L. Knook, and T. J. Van Berkel. 1994. Cholesteryl esters from oxidized low-density lipoproteins are in vivo rapidly hydrolyzed in rat Kupffer cells and transported to liver parenchymal cells and bile. Hepatology. 19: 1459-1467.
26. Ji, Y., N. Wang, R. Ramakrishnan, E. Sehayek, D. Huszar, J. L. Breslow, and A. R. Tall. 1999. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J. Biol. Chem. 274: 33398-33402.
27. Sampson, W. J., K. M. Botham, B. Jackson, and K. E. Suckling. 1988. The effect of inhibition of cholesterol esterification on the fate of cholesterol derived from HDL in rat hepatocyte monolayers. FEBS Lett. 227: 179-182.
28. Pieters, M. N., D. Schouten, H. F. Bakkeren, B. Esbach, A. Brouwer, D. L. Knook, and T. J. van Berkel. 1991. Selective uptake of cholesteryl esters from apolipoprotein-E-free high-density lipoproteins by rat parenchymal cells in vivo is efficiently coupled to bile acid synthesis. Biochem. J. 280: 359-365.
29. Connelly, M. A., and D. L. Williams. 2004. Scavenger receptor BI: a scavenger receptor with a mission to transport high density lipoprotein lipids. Curr. Opin. Lipidol. 15: 287-295.
30. Cohen, D. E., and E. J. Armstrong. 2007. Pharmacology of cholesterol and lipoprotein metabolism. In Principles of Pharmacology. 2nd edition. D. E. Golan, A. H. Tashjian, E. J. Armstrong, J. M. Galanter, A. W. Armstrong, R. A. Arnaout, and H. S. Rose, editors. Lippincott, Philadelphia. 417-438.