Regulation of the assembly and secretion of very low density lipoproteins by the liver

Biological Chemistry

Volumn 379, Issue 8-9, 1998, Pages 1033-1040

  Kendrick, John S ^a   Wilkinson, Jane ^a   Cartwright, Ian J ^a   Lawrence, Scott ^a   Higgins, Joan A ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Apolipoprotein B; Degradation; Dietary oils; Endoplasmic reticulum; Golgi; Lipids

Indexed keywords

APOLIPOPROTEIN B; CHAPERONE; CHOLESTEROL ESTER; EDIBLE OIL; FISH OIL; HEAT SHOCK PROTEIN 70; PROTEASOME; SUNFLOWER OIL; TRIACYLGLYCEROL; UBIQUITIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; CONTROLLED STUDY; GOLGI COMPLEX; LIPOPROTEIN SECRETION; LIPOPROTEIN SYNTHESIS; LIVER CYTOSOL; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN TRANSPORT; REVIEW; ROUGH ENDOPLASMIC RETICULUM;

ANIMALS; HUMANS; LIPOPROTEINS, VLDL; LIVER; PROTEIN PROCESSING, POST-TRANSLATIONAL;

ANIMALIA; HELIANTHUS;

EID: 0031716872     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Alexander, C.A., Hamilton, R.L., and Havel, R.J. (1976). Subcellu-lar localisation of B-apoprotein of plasma lipoprotelns J. Cell Biol. 69, 241-263.
2. Bamberger, M.J., and Lane, M.D. (1988). Assembly of very low density lipoprotein in the hepatocyte. Differential transport of apoproteins through the secretory pathway. J. Biol. Chem. 263, 11868-11878.
3. Borchardt, R.A., and Davis, R.A. (1987). Intracellular assembly of very low density lipoproteins. J. Biol. Chem. 262, 16394-16402.
4. Boren, J., Wettesten, M., Sjoberg, A., Thorin, T., Bondier, G., Wiklund, A., Carlsson, P., and Olofsson, S.-O. (1990). Studies on the assembly of apo-B100 containing lipoproteins in Hep-G2 cells. J. Biol Chem. 263, 4434-4442.
5. Boren, J., Rustaeus, S., Wettesten, M., Andersson, M., Wiklund, A., and Olofsson, S.-O. (1993). Influence of triacylglyceride biosyntheic rate on the assembly of apo-B100 containing lipoproteins in Hep-G2 cells. Arterioscl. Thromb. 13, 1543-1754.
6. Boren, J., Rustaeus, S., and Olofsson, S.-O. (1994). Studies on the assembly of apolipoprotein B100 and B48 containing VLDL in McA RH7777 cells. J. Biol. Chem. 259, 25879-25888.
7. Cartwright, I.J., and Higgins, J.A. (1995). Intracellular events in the assembly of very low density lipoprotein lipids with apolipoprotein B in isolated rabbit hepatocytes Biochem. J. 310, 897-907.
8. Cartwright, I.J., and Higgins, J.A. (1996). Intracellular degradation in the regulation of secretion of apolipoprotein-B 100 by rabbit hepatocytes. Biochem. J. 314, 977-984.
9. Cartwright, I.J., Hebbachi, A.-M., and Higgins, J.A. (1993). Transit and sorting of apolipoprotein B within the endoplasmic reticulum and Golgi compartments of isolated hepatocytes from normal and orotic acid fed rats. J. Biol. Chem. 268, 20937-20952.
10. Cartwright, I.J., Higgins, A., Wilkinson, J., Bellevia, S., Kenrick, S., and Graham, J.M., (1997). Investigation of the role of lipids in the assernbly of VLDL in rabbit hepatocytes. J. Lipid Res. 38, 531-545.
11. Chan, L., and Seeburg, P.H. (1995). RNA editing. Scientific American 2, 68-77.
12. Cianflone, K.M., Yasruel, Z., Rodriguez, M.A., Vas, D., and Sniderman, A.D. (1990). Regulation of apo-B secretion from HepG2 cells; evidence for a critical role for cholesterol ester synthesis in response to a fatty acid challenge J. Lipid Res. 31, 2045-2055.
13. Dashi, N. (1992). The effect of low density lipoprotein cholesterol and 25-hydroxycholesterol on apolipoprotein B gene expression in hepG2 cells. J. Biol. Chem. 267, 7160-7169.
14. Davis R.A., Prewett, D.C., Chan, D.C.F., Thompson, J.J., Borchardt, R.A., and Gallagher, W.R. (1989). Intrahepatic assembly of very low density lipoproteins: immunological characterisation of apolipoprotein B in lipoproteins and hepatic membrane fractions and its intracellular distribution. J. Lipid Res. 30, 1185-1196.
15. Dixon, J. L., and Ginsberg, H.N. (1993). Regulation of hepatic secretion of apolipoprotein B containing lipoproteins: information obtained from cultured liver cells. J. Lipid. Res. 34, 167-178.
16. Dixon, J. L., Furukawa, S., and Ginsberg, H.N. (1991). Oleate stimulats secretion of apo-B containing lipoproteins from Hep-G2 cells by inhibiting early intracellular degradation of apo-B. J. Biol. Chem. 266, 5080-5086.
17. Dixon, J.L., Chattapadhyay, R., Huima, T., Redman, C.N., and Banjeree, D. (1992). Biosynthesis of lipoprotein: location of nascent apo-A1 and apo-B in the rough endoplasmic reticulum of chicken hepatocytes. J. Cell. Biol. 117, 1161-1169.
18. Du, E., Kurth, J., Wang, S.-L., Humiston, P., and Davis, R.A. (1994). Proteolysis coupled secretion of the N-terminus of apolipoprotein B; Characterisation of a transient translocation arrested intermediate. J. Biol. Chem. 269, 24169-24176.
19. Fisher, E.A., Zhou, M., Mitchell, D.M., Wu, X., Omura, A., Wang, H., Goldberg, A.L., and Ginsberg, H.N. (1997). The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein. J. Biol. Chem. 272, 20427-29434.
20. Furukawa, S., and Hirano, T. (1993). Rapid stimulation of apolipoprotein B secretion by oleate is not associated with cholesterol ester syntesis in Hep-G2 cells. Biochim. Biophys. Acta 1170, 32-37.
21. Furukawa, S., Sakata, N., and Ginsberg, H.N. (1992). Studies of the sites of intracellutar degradation of apolipoprotetn B in HepG2 cells. J. Biol. Chem. 277, 18445-18455.
22. Gibbons, G.F. (1994). A comparison of in vitro models to study hepatic lipid and lipoprotein metabolism. Curr. Opin. Lipidol. 23, 495-500.
23. Ginsberg, H.N. (1997). Roie of lipid synthesis, chaperone proteins, and proteosomes in the assembly and secretion of apo-B containing lipoproteins from cultured liver cells. Clin. Exptl. Pharm. and Phys. 24 (Suppl), A29-A32.
24. Gordon, D.A., Jamil, H., Sharp, D., Mullaney, D., Yao, Z., Gregg, R.E., and Wetterau, J. (1994). Secretion of apolipoprotein B containing lipoproteins from HepG2 cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc. Natl. Acad. Sci. 97, 7628-7632.
25. Gordon, D.A., Jamil, H., Gregg, R.E., Olofsson, S.-O., and Boren, J. (1996). Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J. Biol. Chem. 271, 33047-33053.
26. Higgins, J.A., and Hutson, J.L. (1984). The role of Golgi and endoplasmic reticulum in the synthesis and assembly of lipoprotein lipids in rat hepatocytes. J. Lipid Res. 25, 1295-1305.
27. Ingram, M.S., and Shelness, G.S. (1996). Apolipoprotein B destined for lipoprotein assembly and intracellular degradation undergoes efficient translocation across the endoplasmic reticulum membrane. J. Lipid Res. 37, 2202-2214.
28. Kohen-Avramoglu, R., Cianflone, K.M., and Sniderman, A.D. (1995). The role of the neutral lipid accessible pool in the regulation of secretion of apo-B100 lipoprotein particles by Hep-G2 cells. J. Lipid Res. 36, 2513-2528.
29. Kosykh, V.A., Surguchov, A.R., Podres, E.A., Novikov, D.K., and Sudarickoc, N. (1988). VLDL apoprotein secretion and apo-B mRNA levels in primary cultures of cholesterol loaded rabbit hepatocytes. FEBs lett. 232, 103-106.
30. Leiper, J.M., Bayliss, J., Pease, R.J., Brett, D.L., Scott, J., and Shoulders, G.G. (1994). Microsomal triglyceride transfer protein, the abetalipoprotein gene product mediates the secretion of apolipoprotein B containing lipoproteins from heterologous cells. J. Biol. Chem. 269, 21951-21954.
31. Leiper, J.M., Harrison, G.B., Baylis, J.D., Scott, J., and Pease, R.J. (1996). Systematic expression of the complete coding sequence of apo-B100 does not reveal transmembrane determinants. J. Lipid Res. 37, 2215-2231.
32. Packard, C.J., and Shepherd, J. (1987). Lipoprotein metabolism and cariovascular disease Biochem. Soc. Trans. 15, 341-343.
33. Packard, C.J., Munro, A., Lorimer, A.R., Gotto, A.M., and Shepherd, J. (1994). Metabolism of apolipoprotein B in large trlacylglycerol rich VLDL of normal and hypertriglyceridaemic subjects. J. Clin. Invest. 74, 2178-2192.
34. Pullinger, C.R., North, J.D., Teng, B., Rifici, V.A., Ronhild de Brito, A.E., and Scott, J. (1989). The apolipoprotein B gene is constituitively expressed in Hep-G2 cells. J. Lipid Res. 38, 1065-1076.
35. Sato, R., Imanaro, T., and Tanako, T. (1990). The effect of the HMG-CoA reductase inhibitor CS514 on the synthesis and secretion of apolipoprotein B and A1 by human hepatoma HepG2 Biochim. Biophys. Acta 1042, 36-41.
36. Sharp, D., Blinderman, L., Combe, K.A., Kienze, B., Ricci, B., Wagner-Smith, et al. (1993). Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia. Nature 365, 65-69.
37. Shelness, G., Morris-Rogers, K.C., and Ingram, M.F. (1994). Apolipoprotein B48 membrane interactions:absence of transmembrane localization in non-hepatic cells. J. Biol. Chem. 269, 9310-9318.
38. YTISSniderman, A.D., and Cianflone, K. (1993). Substrate delilvery as a determinant of hepatic apo-B secretion. Artersicl. Thombos. 13, 629-636.
39. Wang, C.N., Hobman, T.C., and Brindley, D.N. (1995). Degradation of apolipoprotein B in cultured rat hepatocytes. J. Biol. Chem. 270, 24924-24931.
40. Wetterau, J.R. (1993). Cloning and gene defects in MTP associated with abetalipoproteinaemia. Nature 365, 65-69.
41. Wetterau, J.R. (1993). Cloning and gene defects in MTP associated with abetalipoproteinaemia. Nature 365, 65-69.
42. White, A.L., Graham, D.L., LeGros, J., Pease, R.J., and Scott, J. (1992). Oleate mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. J. Biol. Chem. 267, 15657-15664.
43. Wiertz, E.J.H., Tortore, D., Bogyo, M., Yu, J., Mothes, W., Jones, T.R., Rapaport, T.A., and Ploegh, H.L. (1996). Sec-61 mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for degradation. Nature 384, 432-438.
44. Wilkinson, J., Higgins, J.A., Groot, P.H.E., Gherardi, E., and Bowyer, D.E. (1992). Determination of pool sizes of apolipoprotein B in rabbit liver. Biochem. J. 288, 413-419.
45. Wilkinson, J., Higgins, J.A., Groot, P.H.E., Gherardi, E., and Bowyer, D.E. (1993). Topography of apolipoprotein B in subcellular fractions of rabbit liver probed with a panel of monoclonal antibodies. J. Lipid Res. 34, 815-825.
46. Wilkinson, J., Higgins, J.A., Fitzsimmons, C., and Bowyer, D.E. (1998). Dietary fish-oils modify the assembly of very low den- sity roteins and expression of the LDL receptor in rabbit liver. Arterioscl. and Thromos., in press.
47. Wu, X., Zhou, L.-S., Wetterau, J., and Ginsberg, H.N. (1986). Demonstration of a physical interaction between MTP protein and apo-B during assembly of apo-B containing lipoprotein. J. Biol. Chem. 271, 10277-10281.
48. Wu, X., Sakata, N., Lui, E., and Ginsberg, H.N. (1994). Evidence for a lack of regulation of assembly and secretion of apolipoprotein B containing lipoproteins from Hep-G2 cells by cholesterol ester. J. Biol. Chem. 266, 12357-12382.
49. Wu, X., Sakata, N., Lele, K. M., Zhou, M., Jiang, H., and Ginsberg, H.N. (1997). A two-site model for apo-B degradation in Hep-G2 cells. J. Biol. Chem. 272, 11575-11580.
50. Yao, Z., Tran, K., and McCleod, R. S. (1997). Intracellular degradation of newly synthesised apolipoprotein B. J. Lipid Res. 38, 1937-1953.
51. Yeung, S. J., Chen, S.-W., and Chan, L. (1996). Ubiquitn-proteasome pathway mediated intracellular degradation of apolipoprotein-B. Biochemistry 35, 13843-13848.
52. Zhou, M., Wu, X., Huang, L.-S., and Ginsberg, H.N. (1995).Apolipoprotein B100 an Inefficinetly translocated secretory protein is bound to the cytosolic chaperone heat shock protein 70. J. Biol. Chem. 270, 25220-25224.