The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism

Current Opinion in Lipidology

Volumn 11, Issue 2, 2000, Pages 123-131

  Trigatti, Bernardo ^a   Rigotti, Attilio ^b   Krieger, Monty ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; ESTROGEN; HIGH DENSITY LIPOPROTEIN RECEPTOR; SCAVENGER RECEPTOR; STEROID HORMONE;

BILE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; FAT INTAKE; HOMEOSTASIS; LIVER; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; STEROIDOGENESIS;

ANIMALS; ANTIGENS, CD36; CHOLESTEROL, HDL; LIVER; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B;

MURINAE; RODENTIA;

EID: 0034100119     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200004000-00004     Document Type: Review

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108. 108 Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet 1999; 22:352-355. See [109••]
109. 109 Lawn RM, Wade DP, Garvin MR, Wang X, Schwartz K, Porter JG, et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest 1999; 104:25-31. These breakthrough studies report the identification of the Tangier disease gene as ABC1, indicating that this transmembrane protein plays a key role in cellular cholesterol efflux.
110. 110 Arai T, Wang N, Bezouevski M, Welch C, Tall AR. Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. J Biol Chem 1999; 274:2366-2271. This study together with Ref. [44••] and [111••] demonstrates that SR-BI expression in mice is anti-atherogenic and that it can influence the plasma levels of non-HDL lipoprotein cholesterol.
111. 111 Kozarsky KF, Donahee MH, Glick JM, Krieger M, Rader DJ. Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol 2000; 20:721-727. This study shows that hepatic overexpression of SR-BI is atheroprotective for high fat/high cholesterol-fed LDL receptor knockout mice.
112. 112 Acton S, Osgood D, Donoghue M, Corella D, Pocovi M, Cenarro A, et al. Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population. Arterioscler Thromb Vasc Biol 1999; 19:1734-1743. This human study showed associations between SR-BI gene polymorphisms and plasma lipoprotein cholesterol levels.