Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 4, 2009, Pages 1066-1070

  Anandan, Sampath Kumar ^a   Do, Zung N ^a   Webb, Heather K ^a   Patel, Dinesh V ^a   Gless, Richard D ^a  

^a Arete Therapeutics Inc   (United States)

Author keywords

Non urea; Primary pharmacophore; sEH inhibitors

Indexed keywords

AMIDE; ENZYME INHIBITOR; EPOXIDE HYDROLASE; SULFONAMIDE; SULFONYLUREA; THIOUREA; UREA;

ARTICLE; CARDIOVASCULAR SYSTEM; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; HYPERTENSION; INFLAMMATION; PHARMACOPHORE; SOLUBILITY;

AMIDES; COMBINATORIAL CHEMISTRY TECHNIQUES; EPOXIDE HYDROLASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; THIOUREA;

EID: 59649100565     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.013     Document Type: Article

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